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The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. Additionally we are shipping HBa2 Proteins (6) and many more products for this protein.
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In this study, a novel promoter mutation of -72 (T-->A) within the conserved CCAAT box of beta-globin (show HBB Antibodies) gene has been identified in heterozygous state. The proband and his two relatives carrying the same mutation showed almost normal mean corpuscular volume (MCV) and mean corpuscular hemoglobin (show HBB Antibodies) (MCH (show PMCH Antibodies)) level and slightly elevated HbA2.
Carriers of Hb Nanning are asymptomatic and could be missed by screening based on MCV and MCH (show PMCH Antibodies) cutoffs of <80.0 fL and <27.0 pg, respectively. Both carriers of the mutation in the study have MCV and MCH (show PMCH Antibodies) values that are 2 standard deviations (SDs (show SDS Antibodies)) below normal, as would be predicted for an alpha+-thal.
Data indicate that binding of hemoblobin (Hb) to glycoprotein1balpha (GP1balpha) induced platelet activation plays a crucial role in thrombus formation on immobilized von Willebrand factor (VWF (show VWF Antibodies)) or type I collagen under shear stresses.
Hb Adana mutation was preferentially present in the alpha2-globin genes in Malays compared to the other ethnicities in Malaysia.
Seven novel nondeletional alpha-thalassemia mutations localized on the alpha2-globin gene in the heterozygous state were identified
Gene frequency for HBA2:c.301-24delGinsCTCGGCCC carriers among the Chinese population in Guangxi.
Hemoglobin Constant Spring mutation in Southeast Asians with thalassemia.
We report herein for the first time the description of HbA2' in the Tunisian population.
In maturing RBC (show CACNA1C Antibodies) progenitors AHSP (show aHSP Antibodies) bind to free alpha-globin (show HBA1 Antibodies) chains to increase the HbA (show SCN2A Antibodies) production. (Review)
Two mutations detected the -a(3,7) single gene deletion found in 75% of cases and the nongene deletion a2 IVS1 [-5nt (show ACPP Antibodies)] in the remaining samples
The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin\; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1\; some nondeletion alpha thalassemias have also been reported.
, 2-alpha-1 globin
, hemoglobin alpha 2 chain
, adult alpha D globin
, hemoglobin alpha-D chain
, hemoglobin subunit alpha-D
, hemoglobin, alpha 2
, hemoglobin subunit alpha
, globin, alpha 2
, hemoglobin, subunit alpha 2
, alpha globin
, alpha-2 globin
, hemoglobin alpha chain
, alpha T5 (aa 1-142)
, hemoglobin alpha-5 chain
, hemoglobin subunit alpha-5