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In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Additionally we are shipping HOXA10 Antibodies (71) and HOXA10 Proteins (6) and many more products for this protein.
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These results suggest that downregulation of HOXA10 in the decidual cells promotes the expression of a cascade in the trophoblast cells, leading to an increase in matrix metalloproteinases to facilitate invasion.
Endometrial expression of HOXA10 and E-cadherin (show CDH1 ELISA Kits) are reduced in women with recurrent implantation failure and recurrent miscarriage.
Reduced expression of HOXA10 is associated with Hydrosalpinx.
To summarize, significant differential methylation of HOXA10 and COMT (show COMT ELISA Kits) promoter regions was found between the ectopic and eutopic endometrial tissues. This is the first study investigating the methylation of HOXA10 and COMT (show COMT ELISA Kits) genes and their linkage to endometriosis in Chinese patients.
using both knockdown and knockout approaches we show that Hottip expression is required for activation of the 5' Hoxa genes (Hoxa13 (show HOXA13 ELISA Kits) and Hoxa10/11) and for retaining Mll1 at the 5' end of Hoxa. Moreover, we demonstrate that artificially inducing Hottip expression is sufficient to activate the 5' Hoxa genes and that Hottip RNA binds to the 5' end of Hoxa
HOXA10 is overexpressed in oral squamous cell carcinoma (OSCC) and its expression is functionally associated with several important biological processes related to oral tumorigenesis, such as proliferation, migration and invasion.
The results demonstrated that mutation in HOXA10 gene contributes to the pathogenesis of cryptorchidism, but may not be a common cause.
The HOXA10 gene in women with endometriosis was hypomethylated compared to controls.
HOXA10 was expressed at a high level in the K562/ADM (show ADM ELISA Kits) cells, and knockdown of HOXA10 enhances the sensitivity of the K562/ADM (show ADM ELISA Kits) cells to cytotoxic killing by the therapeutic drug, ADR (show AKR1B1 ELISA Kits), as a result of the increased intracellular accumulation of ADR (show AKR1B1 ELISA Kits).
Regulated HOXA10 and HOXA11 (show HOXA11 ELISA Kits) expression is necessary for endometrial receptivity; decreased HOXA10 or HOXA11 (show HOXA11 ELISA Kits) expression leads to decreased implantation rates. Alternation of HOXA10 and HOXA11 (show HOXA11 ELISA Kits) expression has been identified as a mechanism of the decreased implantation associated with endometriosis, polycystic ovarian syndrome, leiomyoma, polyps, adenomyosis, and hydrosalpinx.
These results suggest that progesterone receptor (show PGR ELISA Kits) overexpression in endometrial stromal cells, likely due to high progesterone levels, triggers cyclin D3 (show CCND3 ELISA Kits) and Hoxa-10 overexpression, which may be involved in the pathological mechanisms of the mouse uterine decidual reaction.
Hmgn5 (show HMGN5 ELISA Kits) might act downstream of Hoxa10 to regulate the expression of Cox-2 (show COX2 ELISA Kits), Vegf (show VEGFA ELISA Kits) and Mmp2 (show MMP2 ELISA Kits).
Our results suggest that NA10HD increases the number of gamma-globin-transduced HSCs that engraft, leading to an elevated number of fetal hemoglobin-containing red cells.
we suggest that proper regional decidualization and polyploidy development requires FoxM1 (show FOXM1 ELISA Kits) signaling downstream of Hoxa10 and cyclin D3 (show CCND3 ELISA Kits).
these studies demonstrate a previously undescribed role for HoxA10 in terminating emergency granulopoiesis, suggesting an important contribution by Hox (show MSH2 ELISA Kits) proteins to the innate immune response.
Hoxa10 cooperates with Nkx2-5 (show NKX2-5 ELISA Kits) to regulate the timing of cardiac mesoderm differentiation.
results show that reduced APC activity is sufficient to induce formation of epithelial inclusion cysts and support ovarian endometrioid adenocarcinoma development and suggest that induced HOXA10 expression and loss of PTEN are key mechanisms driving endometrioid histotype differentiation and progression
a molecular mechanisms through which increased expression of HoxA10 increases Cdx4 expression by direct CDX4 activation and by Fgf2 (show FGF2 ELISA Kits)-induced beta-catenin (show CTNNB1 ELISA Kits) activity. This results in Cdx4-induced HoxA10-expression, creating a positive feedback mechanism
Setbp1 (show SETBP1 ELISA Kits) promotes the self-renewal of murine myeloid progenitors via activation of Hoxa9 (show HOXA9 ELISA Kits) and Hoxa10.
found that increased Fgf2 (show FGF2 ELISA Kits) production by HoxA10-overexpressing myeloid progenitor cells induced a phosphoinositol 3-kinase-dependent increase in beta-catenin (show CTNNB1 ELISA Kits) protein
study identified an E(2)/P(4) response element of the porcine HOXA10 gene for the first time
investigation of regulation of HOXA10 gene expression by estradiol and/or progesterone in porcine endometrium during estrous.
Homeobox A10 expression in the porcine endometrium is closely related to the implantation process and stimulated by conceptus products.
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation. More specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the downstream homeobox A9 (HOXA9) gene.
homeo box A10
, homeobox protein 1H
, homeobox protein HOXA10
, homeobox protein Hox-1.8
, homeobox protein Hox-1H
, homeobox protein Hox-A10
, homeobox protein A10
, homeobox A10
, homeobox A10, isoform 1
, homeobox protein Hox-A10-like
, homeo box A9
, homeo box A10b
, homeobox gene A-10
, homeobox protein Hox-A10b
, homeobox A11
, homeobox protein Hox-A11
, homeobox protein Hox-A11-like