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In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Additionally we are shipping HOXA4 Antibodies (72) and many more products for this protein.
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Overexpression of HOXA4 and HOXA9 (show HOXA9 Proteins) contributes to self-renewal and overpopulation of stem cells in colorectal cancers.
HOXA4 increases short-term repopulation to higher levels than HOXB4 (show HOXB4 Proteins), which may involve Notch (show NOTCH1 Proteins) signaling to induce self-renewal of primitive hematopoietic cells
The NK AML (show RUNX1 Proteins) patients with NPM1 (show NPM1 Proteins) mutations exhibited elevated HOXA4 methylation and expression levels of HOXA5 (show HOXA5 Proteins) and MEIS1 (show MEIS1 Proteins) compared with the NPM1 (show NPM1 Proteins) wildtype patients.
promoter hypermethylation of HOXA4 gene could be an epigenetic mechanism mediating IM resistance in CML patients.
HOXA4 showed nuclear & perinuclear staining in endothelial & smooth muscle cells in aorta. Spatial variation in expression in human aortas persisted into adulthood. Downregulation of HOXA4 expression was associated with abdominal aortic aneurysm.
Studies suggest that HOXA4, HOXA5 (show HOXA5 Proteins) and HOXB4 (show HOXB4 Proteins) provide the spatial information needed to restrict the response to signals from the notochord, and not up regulated in pancreatic cancer.
Results confirm that HOXA4 inhibits cell motility, show that it suppresses cell spreading and filopodia formation while enhancing cell-cell adhesion, and suggest a role for beta1 integrin in mediating these changes.
upregulated significantly in acute myeloid leukemia (show BCL11A Proteins) patients with a white blood cell count higher than 30 x 10(9)/L cells.
aberrant DNA methylation (show HELLS Proteins) may have a major role in the control of HOXA4 gene expression in chronic lymphocytic leukemia
analysis of the role of deregulated PcG genes in acute myeloid leukemia (show BCL11A Proteins), and the downstream PcG targets HOXA4, HOXA9 (show HOXA9 Proteins) and MEIS1 (show MEIS1 Proteins)
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation.
, Hox-1.4-like protein
, homeo box A4
, homeobox protein Hox-1.4
, homeobox protein Hox-1D
, homeobox protein Hox-A4
, homeobox protein MH-3
, homeobox A4
, Homeobox protein Hox-A4
, homeobox protein XlHbox4b
, Homeobox gene A4
, homeobox A4-like
, homeobox protein Hox-A4-like
, homeobox protein R2