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HOXD11 belongs to the homeobox family of genes.
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Knock down of the dickkopf (show DKK1 Antibodies) WNT (show WNT2 Antibodies) signaling pathway inhibitor 2 (DKK2 (show DKK2 Antibodies)) resulted in a significant suppression of HOXD10 (show HOXD10 Antibodies), HOXD11 and HOXD13 (show HOXD13 Antibodies) while over-expression of DKK2 (show DKK2 Antibodies) and stimulation with factors of the WNT (show WNT2 Antibodies) signaling pathway.
High expression of HOXD11 is associated with laryngeal squamous cell carcinoma.
POU2F1 (show POU2F1 Antibodies) activity regulates HOXD10 (show HOXD10 Antibodies) and HOXD11 gene expression in head and neck squamous cell carcinoma, promoting a proliferative and invasive phenotype.
data show no significant difference in HOXD11, HOXD12 (show HOXD12 Antibodies) & HOXD13 (show HOXD13 Antibodies) genotype frequencies between the autism spectrum disorder & healthy controls, but one SNP in promoter region of HOXD11 was observed in only 4 patients with ASD (show ARSD Antibodies)
In human embryonic stem cell (hESCs)differentiation, a 1.8kb region between HOXD11 and HOXD12 (show HOXD12 Antibodies) (D11.12) that is associated with PcG proteins was discovered, it shows alteration in nuclease (show DCLRE1C Antibodies) sensitivity as hESCs differentiate.
The HOXD11 gene is fused to the NUP98 (show NUP98 Antibodies) gene in acute myeloid leukemia (show BCL11A Antibodies) with t(2;11)(q31;p15 (show CDKN2B Antibodies)).
Our findings do not support the hypothesis that mutations in the HOXD11 coding regions are involved in the pathogenesis of human non-syndromal congenital renal parenchymal malformations.
expressed adjacent to the pisiform in late-stage embryonic limbs, supporting a role for Hox (show MSH2 Antibodies) genes in growth plate specification
Hoxa11 (show HOXA11 Antibodies) and Hoxd11 regulate chondrocyte differentiation upstream of Runx2 (show RUNX2 Antibodies) and Shox2 (show SHOX2 Antibodies) in mice.
Hox11 (show TLX1 Antibodies) genes (Hoxa11 (show HOXA11 Antibodies), Hoxc11 (show HOXC11 Antibodies) and Hoxd11) co-regulate and coordinate the development of zeugopod skeletal elements and adjacent elbow and knee joints, and dictate joint identity, morphogenesis and anatomical and functional organization.
mice individually mutant for Hoxa11 (show HOXA11 Antibodies) or Hoxd11 show no discernible kidney abnormalities. Hoxa11 (show HOXA11 Antibodies)/Hoxd11 double mutants, however, demonstrate hypoplasia of the kidneys
analysis of the Hoxd11 duplication demonstrated that the Hoxd11 can perform some functions supplied by its paralogue Hoxa11 (show HOXA11 Antibodies), the defects in forelimb bones are corrected when extra copies of Hoxd11 are present in the Hoxa11 (show HOXA11 Antibodies) homozygous mutant background
malformation of the forelimb zeugopod in Hoxa11 (show HOXA11 Antibodies)/Hoxd11 double mutants is a consequence of interruption at multiple steps during the formation of the radius and ulna
early posterior restriction of Hox (show MSH2 Antibodies) gene products sets up an anterior-posterior prepattern, which determines the localized activation of Shh (show SHH Antibodies); this signal is then translated into digit morphological asymmetry by promoting the late expression of Hoxd genes
identify the multiple molecular pathways downstream of Hoxa11 (show HOXA11 Antibodies)/Hoxd11 function in the developing kidney
Mice lacking all Hox11 (show TLX1 Antibodies) activity fail to form metanephric kidney structures; when Hoxd11 is ectopically activated in the anterior mesonephros, we observe a partial transformation to a metanephric program of development.
mice mutant for Hoxd11 and Hoxa11 (show HOXA11 Antibodies) show absence of radius and ulna, anterior homeotic transformation of vertebra, and severe kidney defects, suggesting Hoxd11 and Hoxa11 (show HOXA11 Antibodies) act together to specify limb outgrowth and patterning of proximodistal axis
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. The product of the mouse Hoxd11 gene plays a role in forelimb morphogenesis.
Hox-4.6, mouse, homolog of
, homeo box 4F
, homeo box D11
, homeobox protein Hox-4F
, homeobox protein Hox-D11
, homeobox protein Hox-4.6
, homeobox protein Hox-5.5
, homeobox gene D-11
, homeobox protein Hox-C11
, homeobox protein Hox-D11a
, Hox D11
, homeobox protein Hox-4E
, homeodomain-containing protein
, homeobox D11
, LOW QUALITY PROTEIN: homeobox protein Hox-D11