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The protein encoded by HABP2 is an extracellular serine protease that binds hyaluronic acid and is involved in cell adhesion. Additionally we are shipping HABP2 Antibodies (40) and HABP2 Kits (7) and many more products for this protein.
Showing 9 out of 17 products:
study on a wide series of familial non-medullary thyroid cancers indicates that the HABP2(G534E) variant is frequent, but does not segregate with the disease
Letter: G534E variant in HABP2 is not associated with non-medullary thyroid cancer in the Spanish population.
Study showed that lower FSAP antigen plasma levels were associated with a higher chance of arterial recanalization after tissue plasminogen activator (show PLAT Proteins) treatment, suggesting an involvement of FSAP in tissue plasminogen activator (show PLAT Proteins)-induced clot (show TXNDC17 Proteins) lysis. FSAP antigen determination might be useful in predicting tissue plasminogen activator (show PLAT Proteins) response in stroke patients.
HABP2 polymorphisms are not associated with thyroid cancer.
the promoter activity, which could phenocopy changes in Habp2 mRNA in response to TGF-beta (show TGFB1 Proteins), was found to be located in the 177-bp region upstream of the transcription start site, and this region did not contain any SMAD (show SMAD1 Proteins) binding sites.
Results show that G534E germline variant in HABP2 does not account for the familial nature of nonmedullary thyroid cancer in Australian kindreds but and is common in the general population.
omology modeling suggested that the Glu (show DCTN1 Proteins)-221 side chain could sterically hinder insertion of the N terminus into the HABP2 protease domain, helping to explain the detrimental effects of Glu (show DCTN1 Proteins)-221 substitution on HABP2 activity.
The data do not support the pathogenicity of the HABP2 c.1601G > A variant but highlight the existence of a new one that should be more extensively searched for in familial papillary thyroid carcinoma patients and its pathogenicity more carefully evaluated.
No evidence supporting a role for the HABP2 G534E variant (SNP rs7080536) in papillary thyroid carcinoma.
HABP2 G534E appears to be a susceptibility gene in a subgroup of Familial Non-Medullary Thyroid Cancer (FNMTC), providing important diagnostic implications for this hereditary thyroid cancer.
FSAP deficiency causes an increase in CCL2 (show CCL2 Proteins) expression and CCL2 (show CCL2 Proteins)-mediated infiltration of leukocytes into the injured vessel
Lack of endogenous FSAP impaired the formation of stable, occlusive thrombi in mice.
Results show that the lack of FSAP in mice worsens the outcome of stroke; in the absence of FSAP there was a stronger inflammatory response and lower cell survival due to insufficient activation of the PI3K/AKT (show AKT1 Proteins) pathway
Lower FSAP expression is associated with enhanced liver fibrosis and inflammation in patients with chronic hepatic disorders and murine experimental liver injury.
Data indicate that FSAP mediates proteolytic cleavage and activation of bone morphogenetic protein-2 (BMP-2 (show BMP2 Proteins)).
Hyaluronic acid binding protein 2 (HABP2) negatively regulates vascular integrity via activation of protease-activated receptor/RhoA (show RHOA Proteins)/Rho kinase (show ROCK2 Proteins) signaling. It represents a potential therapeutic target for syndromes of increased vascular permeability.
The protein encoded by this gene is an extracellular serine protease that binds hyaluronic acid and is involved in cell adhesion. The encoded protein is synthesized as a single chain, but then undergoes an autoproteolytic event to form the functional heterodimer. Further autoproteolysis leads to smaller, inactive peptides. This protease is known to cleave urinary plasminogen activator, coagulation factor VII, and the alpha and beta chains of fibrinogen, but not prothrombin, plasminogen, or the gamma chain of fibrinogen. Two transcript variants encoding different isoforms have been found for this gene.
hyaluronan binding protein 2
, hyaluronan-binding protein 2-like
, factor VII activating protein
, factor VII-activating protease
, factor seven-activating protease
, hepatocyte growth factor activator-like protein
, hyaluronan-binding protein 2
, hyaluronic acid binding protein 2
, plasma hyaluronan binding protein
, plasma hyaluronan-binding protein
, hyaduronic acid-binding protein 2