Hyaluronan Binding Protein 2 Proteins (HABP2)

The protein encoded by HABP2 is an extracellular serine protease that binds hyaluronic acid and is involved in cell adhesion. Additionally we are shipping HABP2 Antibodies (41) and HABP2 Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HABP2 3026 Q14520
HABP2 292126 Q6L711
HABP2 226243 Q8K0D2
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Top HABP2 Proteins at antibodies-online.com

Showing 9 out of 17 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
Escherichia coli (E. coli) Human His-SUMO Tag   50 μg Log in to see 11 Days
$341.00
Details
Mammalian Cells Human His tag   50 μg Log in to see 4 Days
$548.63
Details
Human Human His tag   10 μg Log in to see 15 to 16 Days
$300.00
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$2,759.17
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$2,759.17
Details
Escherichia coli (E. coli) Human His tag   100 μg Log in to see 15 to 18 Days
$640.00
Details

HABP2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, ,
Rat (Rattus)

Mouse (Murine)

More Proteins for Hyaluronan Binding Protein 2 (HABP2) Interaction Partners

Human Hyaluronan Binding Protein 2 (HABP2) interaction partners

  1. Study showed that lower FSAP antigen plasma levels were associated with a higher chance of arterial recanalization after tissue plasminogen activator (show PLAT Proteins) treatment, suggesting an involvement of FSAP in tissue plasminogen activator (show PLAT Proteins)-induced clot (show TXNDC17 Proteins) lysis. FSAP antigen determination might be useful in predicting tissue plasminogen activator (show PLAT Proteins) response in stroke patients.

  2. HABP2 polymorphisms are not associated with thyroid cancer.

  3. the promoter activity, which could phenocopy changes in Habp2 mRNA in response to TGF-beta (show TGFB1 Proteins), was found to be located in the 177-bp region upstream of the transcription start site, and this region did not contain any SMAD (show SMAD1 Proteins) binding sites.

  4. Results show that G534E germline variant in HABP2 does not account for the familial nature of nonmedullary thyroid cancer in Australian kindreds but and is common in the general population.

  5. omology modeling suggested that the Glu (show DCTN1 Proteins)-221 side chain could sterically hinder insertion of the N terminus into the HABP2 protease domain, helping to explain the detrimental effects of Glu (show DCTN1 Proteins)-221 substitution on HABP2 activity.

  6. The data do not support the pathogenicity of the HABP2 c.1601G > A variant but highlight the existence of a new one that should be more extensively searched for in familial papillary thyroid carcinoma patients and its pathogenicity more carefully evaluated.

  7. No evidence supporting a role for the HABP2 G534E variant (SNP rs7080536) in papillary thyroid carcinoma.

  8. HABP2 G534E appears to be a susceptibility gene in a subgroup of Familial Non-Medullary Thyroid Cancer (FNMTC), providing important diagnostic implications for this hereditary thyroid cancer.

  9. HABP2, which encodes an extracellular serine protease involved in coagulation, fibrinolysis, and inflammatory pathways, may be a genetic susceptibility locus for early-onset stroke. [Meta-Analysis]

  10. Patients with Gram-negative sepsis caused by B. pseudomallei have abundant FSAP activation, which significantly correlates with stage of disease.

Mouse (Murine) Hyaluronan Binding Protein 2 (HABP2) interaction partners

  1. the promoter activity, which could phenocopy changes in Habp2 mRNA in response to TGF-beta (show TGFB1 Proteins), was found to be located in the 177-bp region upstream of the transcription start site, and this region did not contain any SMAD (show SMAD1 Proteins) binding sites.

  2. Lack of endogenous FSAP impaired the formation of stable, occlusive thrombi in mice.

  3. Results show that the lack of FSAP in mice worsens the outcome of stroke; in the absence of FSAP there was a stronger inflammatory response and lower cell survival due to insufficient activation of the PI3K/AKT (show AKT1 Proteins) pathway

  4. Lower FSAP expression is associated with enhanced liver fibrosis and inflammation in patients with chronic hepatic disorders and murine experimental liver injury.

  5. Data indicate that FSAP mediates proteolytic cleavage and activation of bone morphogenetic protein-2 (BMP-2 (show BMP2 Proteins)).

  6. Hyaluronic acid binding protein 2 (HABP2) negatively regulates vascular integrity via activation of protease-activated receptor/RhoA (show RHOA Proteins)/Rho kinase (show ROCK2 Proteins) signaling. It represents a potential therapeutic target for syndromes of increased vascular permeability.

HABP2 Protein Profile

Protein Summary

The protein encoded by this gene is an extracellular serine protease that binds hyaluronic acid and is involved in cell adhesion. The encoded protein is synthesized as a single chain, but then undergoes an autoproteolytic event to form the functional heterodimer. Further autoproteolysis leads to smaller, inactive peptides. This protease is known to cleave urinary plasminogen activator, coagulation factor VII, and the alpha and beta chains of fibrinogen, but not prothrombin, plasminogen, or the gamma chain of fibrinogen. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with HABP2

  • hyaluronan binding protein 2 (HABP2)
  • hyaluronan binding protein 2 (habp2)
  • hyaluronan binding protein 2 (Habp2)
  • hyaluronic acid binding protein 2 (Habp2)
  • AI035669 protein
  • Fsap protein
  • Habp protein
  • habp2 protein
  • HGFAL protein
  • Phbp protein

Protein level used designations for HABP2

hyaluronan binding protein 2 , hyaluronan-binding protein 2-like , factor VII activating protein , factor VII-activating protease , factor seven-activating protease , hepatocyte growth factor activator-like protein , hyaluronan-binding protein 2 , hyaluronic acid binding protein 2 , plasma hyaluronan binding protein , plasma hyaluronan-binding protein , hyaduronic acid-binding protein 2

GENE ID SPECIES
423898 Gallus gallus
450744 Pan troglodytes
477822 Canis lupus familiaris
548376 Xenopus (Silurana) tropicalis
697495 Macaca mulatta
100068293 Equus caballus
100223786 Taeniopygia guttata
100407842 Callithrix jacchus
100461891 Pongo abelii
100472238 Ailuropoda melanoleuca
100591352 Nomascus leucogenys
3026 Homo sapiens
507993 Bos taurus
292126 Rattus norvegicus
226243 Mus musculus
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