anti-IKAROS Family Zinc Finger 3 (Aiolos) (IKZF3) Antibodies

Human IKAROS Family Zinc Finger 3 (Aiolos) (IKZF3) interaction partners

1. we identified and characterised oncogenic fusion genes and their function in CRC, and implicated NAGLU-IKZF3 and RNF121-FOLR2 as novel molecular targets for personalised medicine development.

2. The minor alleles of rs2941522, rs907091, rs1453559, rs12150079 and rs2872507 were statistically associated with an increased risk in Graves' disease patients.

3. Aiolos promotes the binding of Blimp-1 to target genes and thereby enhances Blimp-1-dependent transcriptional repression.

4. IKZF1 and IKZF3 expressions were associated with longer median progression free survival and overall survival in multiple myeloma patients

5. Inhibition of B cell plasmablast differentiation by reduction of Aiolos and Ikaros may have utility in the treatment of systemic lupus erythematosus , where elevated levels of BAFF and Aiolos may prime CD27(+) memory and double negative memory-like B cells to become Ab-producing plasmablasts in the presence of BAFF and proinflammatory cytokines.

6. this study shows that Ikaros undergoes a transient increase in protein levels at the transitional single-positive CD8+ developmental stage before diverging in their expression patterns at later stages

7. Our data indicate a possible regulatory role for the multiple sclerosis-associated IKZF3 and IQGAP1 variants.

8. results indicate that overexpression of Aiolos may contribute to pathogenesis of SLE and RA

9. Aiolos improved the survival of Nalm6 cells via PTEN and Aktdependent processes.

10. NFKB1, CD27, LAG3 and IKZF3 are new susceptibility genes for psoriasis.

11. lentivirus-mediated AIOLOS overexpression in Jurkat cells induced cell apoptosis, arrested the cell cycle at the G0/G1 phase, and synergistically increased the sensitivity of Jurkat cells to etoposide by inhibiting NF-kappaB activity.

12. identified a unique case of adult acute B-cell lymphoblastic leukemia with masked low hypodiploidy (mLH) by genomic duplication

13. The allele T of rs10852936 surrounding the IKZF3-ZPBP2 locus confers risk for early-onset psoriasis.

14. A strong association between rs907091 in the IKZF3 gene and SLE was identified.

15. The immunosuppressive enzyme IL4I1 expressed differentially in human induced Aiolos+, but not natural Helios+, FOXP3+ Treg cells.

16. A strong allelic association between SNPs in the 17q21 region (IKZF3) and asthma has been confirmed for the Latinos population.

17. Overexpression of AIOLOS inhibits cell proliferation, suppresses apoptosis and arrests the cell cycle at the G0/G1 phase in vitro.

18. Aiolos reconfigures chromatin structure within the SHC1 gene, causing isoform-specific silencing of the anchorage reporter p66(Shc) and blocking anoikis in vitro and in vivo.

19. Sixteen SNPs were significantly associated with asthma of which one SNP was novel (IKZF3-rs1453559).

20. Four additional susceptibility loci (IRF8, TMEM39A, IKZF3, and ZPBP2) for systemic lupus erythematosus were robustly established a multiethnic population (European, African American, Asian, Hispanic, Gullah, and Amerindian).

Mouse (Murine) IKAROS Family Zinc Finger 3 (Aiolos) (IKZF3) interaction partners

1. These data place Aiolos in the emerging gene regulatory network controlling NK-cell maturation and function.

2. study demonstrated that Aiolos silenced the Il2 locus, promoting TH17 differentiation in vitro and in vivo

3. Aiolos and Ikaros bind to the c-myc promoter in vivo and directly suppress c-myc expression in pre-B cells.

4. Normal Aiolos function is necessary to maintain immune homeostasis and suppress the development of systemic autoimmune disease; Aiolos is implicated as a possible candidate gene for systemic lupus erythematosus.

5. A model is proposed for the control of Bcl-xL's anti-apoptotic role in IL-4-deprived cells via association to the transcription factor Aiolos.

6. Failure to generate high affinity plasma cells in the bone marrow and to sustain serum antibody titers is apparent after both primary and secondary immunization of Aiolos(-)(/)(-) mice with a range of hapten concentrations.

7. A novel role for OBF-1 and Aiolos in controlling the transcription and nuclear organization of genes involved in pre-BCR function.