anti-IKAROS Family Zinc Finger 3 (Aiolos) (IKZF3) Antibodies

IKZF3 encodes a member of the Ikaros family of zinc-finger proteins. Additionally we are shipping IKZF3 Proteins (4) and IKZF3 Kits (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
IKZF3 22806 Q9UKT9
IKZF3 22780 O08900
IKZF3 303511  
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Top anti-IKZF3 Antibodies at antibodies-online.com

Showing 10 out of 140 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-IKZF3 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  Transfected 293T 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-IKZF3 Antibody Titration:  0.2-1 ug/ml  Positive Control:  HepG2 cell lysate Human Liver 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated IC, IF, WB Western blot analysis of AIOLOS expression in HepG2 (A), HeLa (B) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from COLO cells, using IKZF3 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Mouse Alexa Fluor 647 FACS Detection of Aiolos/IKZF3 in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) were stained with Mouse Anti-Human CD19 PE-conjugated Monoclonal Antibody. To facilitate intracellular staining, cells were fixed and permeabilized with FlowX FoxP3 Fixation & 25 Tests Log in to see 8 to 9 Days
$168.37
Details
Human Mouse Alexa Fluor 488 FACS Detection of Aiolos/IKZF3 in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) were stained with Mouse Anti-Human CD19 APC-conjugated Monoclonal Antibody. 25 Tests Log in to see 8 to 9 Days
$178.54
Details
Human Mouse Un-conjugated CyTOF, FACS Detection of Aiolos/IKZF3 in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) were stained with Mouse Anti-Human CD19 APC-conjugated Monoclonal Antibody. 100 μg Log in to see 8 to 9 Days
$246.34
Details
Human Mouse Un-conjugated ELISA, IF Immunofluorescence of monoclonal antibody to IKZF3 on HeLa cell. [antibody concentration 10 ug/ml] 100 μg Log in to see 8 to 11 Days
$527.50
Details
Human Rabbit Un-conjugated WB Western Blot: IKZF3 Antibody [NBP2-16938] - Sample (30 ug of whole cell lysate) A: Jurkat 10% SDS PAGE gel, diluted at 1:2000. 0.1 mL Log in to see 8 to 11 Days
$559.35
Details
Cow Rabbit Un-conjugated WB Host: Rabbit Target Name: IKZF3 Sample Type: Lymph Node Tumor lysates Antibody Dilution: 1.0ug/ml 100 μL Log in to see 2 to 3 Days
$289.00
Details

Top referenced anti-IKZF3 Antibodies

  1. Human Polyclonal IKZF3 Primary Antibody for ICC, IF - ABIN4278882 : Zhu, Braggio, Shi, Kortuem, Bruins, Schmidt, Chang, Langlais, Luo, Jedlowski, LaPlant, Laumann, Fonseca, Bergsagel, Mikhael, Lacy, Champion, Stewart: Identification of cereblon-binding proteins and relationship with response and survival after IMiDs in multiple myeloma. in Blood 2014 (PubMed)
    Show all 5 Pubmed References

  2. Human Monoclonal IKZF3 Primary Antibody for IF, ELISA - ABIN564938 : Matulic, Paradzik, Cicin-Sain, Kapitanovic, Dubravcic, Batinic, Antica: Ikaros family transcription factors in chronic and acute leukemia. in American journal of hematology 2009 (PubMed)

  3. Mouse (Murine) Monoclonal IKZF3 Primary Antibody for ChIP, WB - ABIN2668825 : Thompson, Cobb, Sabbattini, Meixlsperger, Parelho, Liberg, Taylor, Dillon, Georgopoulos, Jumaa, Smale, Fisher, Merkenschlager: Ikaros DNA-binding proteins as integral components of B cell developmental-stage-specific regulatory circuits. in Immunity 2007 (PubMed)

  4. Human Polyclonal IKZF3 Primary Antibody for WB - ABIN4278875 : Kinoshita, Ri, Kanamori, Aoki, Yoshida, Narita, Totani, Ito, Kusumoto, Ishida, Komatsu, Iida: Potent antitumor effect of combination therapy with sub-optimal doses of Akt inhibitors and pomalidomide plus dexamethasone in multiple myeloma. in Oncology letters 2018 (PubMed)

More Antibodies against IKZF3 Interaction Partners

Human IKAROS Family Zinc Finger 3 (Aiolos) (IKZF3) interaction partners

  1. The minor alleles of rs2941522, rs907091, rs1453559, rs12150079 and rs2872507 were statistically associated with an increased risk in Graves' disease patients.

  2. Aiolos promotes the binding of Blimp-1 to target genes and thereby enhances Blimp-1-dependent transcriptional repression.

  3. IKZF1 and IKZF3 expressions were associated with longer median progression free survival and overall survival in multiple myeloma patients

  4. Inhibition of B cell plasmablast differentiation by reduction of Aiolos and Ikaros may have utility in the treatment of systemic lupus erythematosus , where elevated levels of BAFF and Aiolos may prime CD27(+) memory and double negative memory-like B cells to become Ab-producing plasmablasts in the presence of BAFF and proinflammatory cytokines.

  5. this study shows that Ikaros undergoes a transient increase in protein levels at the transitional single-positive CD8+ developmental stage before diverging in their expression patterns at later stages

  6. Our data indicate a possible regulatory role for the multiple sclerosis-associated IKZF3 and IQGAP1 variants.

  7. results indicate that overexpression of Aiolos may contribute to pathogenesis of SLE and RA

  8. Aiolos improved the survival of Nalm6 cells via PTEN and Aktdependent processes.

  9. NFKB1, CD27, LAG3 and IKZF3 are new susceptibility genes for psoriasis.

  10. lentivirus-mediated AIOLOS overexpression in Jurkat cells induced cell apoptosis, arrested the cell cycle at the G0/G1 phase, and synergistically increased the sensitivity of Jurkat cells to etoposide by inhibiting NF-kappaB activity.

  11. identified a unique case of adult acute B-cell lymphoblastic leukemia with masked low hypodiploidy (mLH) by genomic duplication

  12. The allele T of rs10852936 surrounding the IKZF3-ZPBP2 locus confers risk for early-onset psoriasis.

  13. A strong association between rs907091 in the IKZF3 gene and SLE was identified.

  14. The immunosuppressive enzyme IL4I1 expressed differentially in human induced Aiolos+, but not natural Helios+, FOXP3+ Treg cells.

  15. A strong allelic association between SNPs in the 17q21 region (IKZF3) and asthma has been confirmed for the Latinos population.

  16. Overexpression of AIOLOS inhibits cell proliferation, suppresses apoptosis and arrests the cell cycle at the G0/G1 phase in vitro.

  17. Aiolos reconfigures chromatin structure within the SHC1 gene, causing isoform-specific silencing of the anchorage reporter p66(Shc) and blocking anoikis in vitro and in vivo.

  18. Sixteen SNPs were significantly associated with asthma of which one SNP was novel (IKZF3-rs1453559).

  19. Four additional susceptibility loci (IRF8, TMEM39A, IKZF3, and ZPBP2) for systemic lupus erythematosus were robustly established a multiethnic population (European, African American, Asian, Hispanic, Gullah, and Amerindian).

  20. To determine the consequences of Aiolos deregulation in B-CLL, we analyzed the effects of Aiolos overexpression or down-regulation on apoptosis.

Mouse (Murine) IKAROS Family Zinc Finger 3 (Aiolos) (IKZF3) interaction partners

  1. These data place Aiolos in the emerging gene regulatory network controlling NK-cell maturation and function.

  2. study demonstrated that Aiolos silenced the Il2 locus, promoting TH17 differentiation in vitro and in vivo

  3. Aiolos and Ikaros bind to the c-myc promoter in vivo and directly suppress c-myc expression in pre-B cells.

  4. Normal Aiolos function is necessary to maintain immune homeostasis and suppress the development of systemic autoimmune disease; Aiolos is implicated as a possible candidate gene for systemic lupus erythematosus.

  5. A model is proposed for the control of Bcl-xL's anti-apoptotic role in IL-4-deprived cells via association to the transcription factor Aiolos.

  6. Failure to generate high affinity plasma cells in the bone marrow and to sustain serum antibody titers is apparent after both primary and secondary immunization of Aiolos(-)(/)(-) mice with a range of hapten concentrations.

  7. A novel role for OBF-1 and Aiolos in controlling the transcription and nuclear organization of genes involved in pre-BCR function.

IKZF3 Antigen Profile

Protein Summary

This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants.

Gene names and symbols associated with IKZF3

  • IKAROS family zinc finger 3 (IKZF3) antibody
  • IKAROS family zinc finger 3 L homeolog (ikzf3.L) antibody
  • IKAROS family zinc finger 3 (Ikzf3) antibody
  • 5830411O07Rik antibody
  • aio antibody
  • Aiolos antibody
  • IKZF3 antibody
  • Zfpn1a3 antibody
  • Znfn1a3 antibody

Protein level used designations for IKZF3

zinc finger protein Aiolos , zinc finger protein, subfamily 1A, 3 (Aiolos) , lymphoid transcription factor , IKAROS family zinc finger 3 (Aiolos) , ikaros family zinc finger protein 3 , zinc finger protein Aiolos-like

GENE ID SPECIES
22806 Homo sapiens
444381 Xenopus laevis
395614 Gallus gallus
468232 Pan troglodytes
491020 Canis lupus familiaris
540676 Bos taurus
698083 Macaca mulatta
100015975 Monodelphis domestica
100085644 Ornithorhynchus anatinus
100392424 Callithrix jacchus
100445787 Pongo abelii
100604740 Nomascus leucogenys
22780 Mus musculus
303511 Rattus norvegicus
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