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IKZF3 encodes a member of the Ikaros family of zinc-finger proteins. Additionally we are shipping IKZF3 Proteins (4) and IKZF3 Kits (1) and many more products for this protein.
Showing 10 out of 137 products:
Human Polyclonal IKZF3 Primary Antibody for ICC, IF - ABIN4278882
Zhu, Braggio, Shi, Kortuem, Bruins, Schmidt, Chang, Langlais, Luo, Jedlowski, LaPlant, Laumann, Fonseca, Bergsagel, Mikhael, Lacy, Champion, Stewart: Identification of cereblon-binding proteins and relationship with response and survival after IMiDs in multiple myeloma. in Blood 2014
Show all 5 Pubmed References
Human Monoclonal IKZF3 Primary Antibody for IF, ELISA - ABIN564938
Matulic, Paradzik, Cicin-Sain, Kapitanovic, Dubravcic, Batinic, Antica: Ikaros family transcription factors in chronic and acute leukemia. in American journal of hematology 2009
Mouse (Murine) Monoclonal IKZF3 Primary Antibody for ChIP, WB - ABIN2668825
Thompson, Cobb, Sabbattini, Meixlsperger, Parelho, Liberg, Taylor, Dillon, Georgopoulos, Jumaa, Smale, Fisher, Merkenschlager: Ikaros DNA-binding proteins as integral components of B cell developmental-stage-specific regulatory circuits. in Immunity 2007
Aiolos promotes the binding of Blimp-1 (show PRDM1 Antibodies) to target genes and thereby enhances Blimp-1 (show PRDM1 Antibodies)-dependent transcriptional repression.
IKZF1 (show IKZF1 Antibodies) and IKZF3 expressions were associated with longer median progression free survival and overall survival in multiple myeloma patients
Inhibition of B cell plasmablast differentiation by reduction of Aiolos and Ikaros (show IKZF1 Antibodies) may have utility in the treatment of systemic lupus erythematosus , where elevated levels of BAFF (show TNFSF13B Antibodies) and Aiolos may prime CD27 (show CD27 Antibodies)(+) memory and double negative memory-like B cells to become Ab-producing plasmablasts in the presence of BAFF (show TNFSF13B Antibodies) and proinflammatory cytokines.
this study shows that Ikaros (show IKZF1 Antibodies) undergoes a transient increase in protein levels at the transitional single-positive CD8 (show CD8A Antibodies)+ developmental stage before diverging in their expression patterns at later stages
Our data indicate a possible regulatory role for the multiple sclerosis-associated IKZF3 and IQGAP1 (show IQGAP1 Antibodies) variants.
results indicate that overexpression of Aiolos may contribute to pathogenesis of SLE and RA
Aiolos improved the survival of Nalm6 cells via PTEN and Aktdependent processes.
NFKB1 (show NFKB1 Antibodies), CD27 (show CD27 Antibodies), LAG3 (show LAG3 Antibodies) and IKZF3 are new susceptibility genes for psoriasis.
lentivirus-mediated AIOLOS overexpression in Jurkat cells induced cell apoptosis, arrested the cell cycle at the G0/G1 phase, and synergistically increased the sensitivity of Jurkat cells to etoposide by inhibiting NF-kappaB (show NFKB1 Antibodies) activity.
The allele T of rs10852936 surrounding the IKZF3-ZPBP2 (show ZPBP2 Antibodies) locus confers risk for early-onset psoriasis.
These data place Aiolos in the emerging gene regulatory network controlling NK-cell maturation and function.
study demonstrated that Aiolos silenced the Il2 (show IL2 Antibodies) locus, promoting TH17 differentiation in vitro and in vivo
Aiolos and Ikaros (show IKZF1 Antibodies) bind to the c-myc (show MYC Antibodies) promoter in vivo and directly suppress c-myc (show MYC Antibodies) expression in pre-B cells.
Normal Aiolos function is necessary to maintain immune homeostasis and suppress the development of systemic autoimmune disease; Aiolos is implicated as a possible candidate gene for systemic lupus erythematosus.
A model is proposed for the control of Bcl-xL's anti-apoptotic role in IL-4 (show IL4 Antibodies)-deprived cells via association to the transcription factor Aiolos.
Failure to generate high affinity plasma cells in the bone marrow and to sustain serum antibody titers is apparent after both primary and secondary immunization of Aiolos(-)(/)(-) mice with a range of hapten concentrations.
A novel role for OBF-1 (show POU2AF1 Antibodies) and Aiolos in controlling the transcription and nuclear organization of genes involved in pre-BCR (show BCR Antibodies) function.
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants.
zinc finger protein Aiolos
, zinc finger protein, subfamily 1A, 3 (Aiolos)
, lymphoid transcription factor
, IKAROS family zinc finger 3 (Aiolos)
, ikaros family zinc finger protein 3
, zinc finger protein Aiolos-like