anti-IKAROS Family Zinc Finger 3 (Aiolos) (IKZF3) Antibodies

Human IKAROS Family Zinc Finger 3 (Aiolos) (IKZF3) interaction partners

1. Aiolos promotes the binding of Blimp-1 (show PRDM1 Antibodies) to target genes and thereby enhances Blimp-1 (show PRDM1 Antibodies)-dependent transcriptional repression.

2. IKZF1 (show IKZF1 Antibodies) and IKZF3 expressions were associated with longer median progression free survival and overall survival in multiple myeloma patients

3. Inhibition of B cell plasmablast differentiation by reduction of Aiolos and Ikaros (show IKZF1 Antibodies) may have utility in the treatment of systemic lupus erythematosus , where elevated levels of BAFF (show TNFSF13B Antibodies) and Aiolos may prime CD27 (show CD27 Antibodies)(+) memory and double negative memory-like B cells to become Ab-producing plasmablasts in the presence of BAFF (show TNFSF13B Antibodies) and proinflammatory cytokines.

4. this study shows that Ikaros (show IKZF1 Antibodies) undergoes a transient increase in protein levels at the transitional single-positive CD8 (show CD8A Antibodies)+ developmental stage before diverging in their expression patterns at later stages

5. Our data indicate a possible regulatory role for the multiple sclerosis-associated IKZF3 and IQGAP1 (show IQGAP1 Antibodies) variants.

6. results indicate that overexpression of Aiolos may contribute to pathogenesis of SLE and RA

7. Aiolos improved the survival of Nalm6 cells via PTEN and Aktdependent processes.

8. NFKB1 (show NFKB1 Antibodies), CD27 (show CD27 Antibodies), LAG3 (show LAG3 Antibodies) and IKZF3 are new susceptibility genes for psoriasis.

9. lentivirus-mediated AIOLOS overexpression in Jurkat cells induced cell apoptosis, arrested the cell cycle at the G0/G1 phase, and synergistically increased the sensitivity of Jurkat cells to etoposide by inhibiting NF-kappaB (show NFKB1 Antibodies) activity.

10. The allele T of rs10852936 surrounding the IKZF3-ZPBP2 (show ZPBP2 Antibodies) locus confers risk for early-onset psoriasis.

Mouse (Murine) IKAROS Family Zinc Finger 3 (Aiolos) (IKZF3) interaction partners

1. These data place Aiolos in the emerging gene regulatory network controlling NK-cell maturation and function.

2. study demonstrated that Aiolos silenced the Il2 (show IL2 Antibodies) locus, promoting TH17 differentiation in vitro and in vivo

3. Aiolos and Ikaros (show IKZF1 Antibodies) bind to the c-myc (show MYC Antibodies) promoter in vivo and directly suppress c-myc (show MYC Antibodies) expression in pre-B cells.

4. Normal Aiolos function is necessary to maintain immune homeostasis and suppress the development of systemic autoimmune disease; Aiolos is implicated as a possible candidate gene for systemic lupus erythematosus.

5. A model is proposed for the control of Bcl-xL's anti-apoptotic role in IL-4 (show IL4 Antibodies)-deprived cells via association to the transcription factor Aiolos.

6. Failure to generate high affinity plasma cells in the bone marrow and to sustain serum antibody titers is apparent after both primary and secondary immunization of Aiolos(-)(/)(-) mice with a range of hapten concentrations.

7. A novel role for OBF-1 (show POU2AF1 Antibodies) and Aiolos in controlling the transcription and nuclear organization of genes involved in pre-BCR (show BCR Antibodies) function.