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IKZF3 encodes a member of the Ikaros family of zinc-finger proteins. Additionally we are shipping IKZF3 Antibodies (143) and IKZF3 Kits (2) and many more products for this protein.
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Aiolos promotes the binding of Blimp-1 (show PRDM1 Proteins) to target genes and thereby enhances Blimp-1 (show PRDM1 Proteins)-dependent transcriptional repression.
IKZF1 (show IKZF1 Proteins) and IKZF3 expressions were associated with longer median progression free survival and overall survival in multiple myeloma patients
Inhibition of B cell plasmablast differentiation by reduction of Aiolos and Ikaros (show IKZF1 Proteins) may have utility in the treatment of systemic lupus erythematosus , where elevated levels of BAFF (show TNFSF13B Proteins) and Aiolos may prime CD27 (show CD27 Proteins)(+) memory and double negative memory-like B cells to become Ab-producing plasmablasts in the presence of BAFF (show TNFSF13B Proteins) and proinflammatory cytokines.
this study shows that Ikaros (show IKZF1 Proteins) undergoes a transient increase in protein levels at the transitional single-positive CD8 (show CD8A Proteins)+ developmental stage before diverging in their expression patterns at later stages
Our data indicate a possible regulatory role for the multiple sclerosis-associated IKZF3 and IQGAP1 (show IQGAP1 Proteins) variants.
results indicate that overexpression of Aiolos may contribute to pathogenesis of SLE and RA
Aiolos improved the survival of Nalm6 cells via PTEN and Aktdependent processes.
NFKB1 (show NFKB1 Proteins), CD27 (show CD27 Proteins), LAG3 (show LAG3 Proteins) and IKZF3 are new susceptibility genes for psoriasis.
lentivirus-mediated AIOLOS overexpression in Jurkat cells induced cell apoptosis, arrested the cell cycle at the G0/G1 phase, and synergistically increased the sensitivity of Jurkat cells to etoposide by inhibiting NF-kappaB (show NFKB1 Proteins) activity.
The allele T of rs10852936 surrounding the IKZF3-ZPBP2 (show ZPBP2 Proteins) locus confers risk for early-onset psoriasis.
These data place Aiolos in the emerging gene regulatory network controlling NK-cell maturation and function.
study demonstrated that Aiolos silenced the Il2 (show IL2 Proteins) locus, promoting TH17 differentiation in vitro and in vivo
Aiolos and Ikaros (show IKZF1 Proteins) bind to the c-myc (show MYC Proteins) promoter in vivo and directly suppress c-myc (show MYC Proteins) expression in pre-B cells.
Normal Aiolos function is necessary to maintain immune homeostasis and suppress the development of systemic autoimmune disease; Aiolos is implicated as a possible candidate gene for systemic lupus erythematosus.
A model is proposed for the control of Bcl-xL's anti-apoptotic role in IL-4 (show IL4 Proteins)-deprived cells via association to the transcription factor Aiolos.
Failure to generate high affinity plasma cells in the bone marrow and to sustain serum antibody titers is apparent after both primary and secondary immunization of Aiolos(-)(/)(-) mice with a range of hapten concentrations.
A novel role for OBF-1 (show POU2AF1 Proteins) and Aiolos in controlling the transcription and nuclear organization of genes involved in pre-BCR (show BCR Proteins) function.
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants.
zinc finger protein Aiolos
, zinc finger protein, subfamily 1A, 3 (Aiolos)
, lymphoid transcription factor
, IKAROS family zinc finger 3 (Aiolos)
, ikaros family zinc finger protein 3
, zinc finger protein Aiolos-like