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Members of the Ikaros (ZNFN1A1\; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM, Jul 2002].. Additionally we are shipping IKZF4 Antibodies (41) and IKZF4 Kits (2) and many more products for this protein.
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this study reports that IL-6 actively suppressed Eos mRNA and protein expression through miR-17
Ikaros (show IKZF1 Proteins) may not be a conventional activator or repressor of defined sets of genes, but may sharpen the dynamic range of gene expression changes during developmental transitions
Eos is redundant for regulatory T cell function but plays an important role in IL-2 (show IL2 Proteins) and IL-17 (show IL17A Proteins) production by CD4 (show CD4 Proteins)+ conventional T cells.
Data indicate that miR-17 promotes TH17 differentiation by repressing target Ikaros Family Zinc Finger 4 (IKZF4).
We show that reprogramming is controlled by downregulation of the transcription factor Eos (Ikzf4), an obligate corepressor for Foxp3 (show FOXP3 Proteins).
Data suggest that Eos, MITF (show MITF Proteins), and PU.1 recruit corepressors to osteoclast-specific genes in committed myeloid progenitor cells.
study identified Eos as a critical mediator of Foxp3 (show FOXP3 Proteins)-dependent gene silencing in CD4 (show CD4 Proteins)+ regulatory T cells (Tregs); Eos interacts directly with Foxp3 (show FOXP3 Proteins) and induces chromatin modifications that result in gene silencing in Tregs
IKZF4 polymorphism (rs1701704) was strongly associated with insulin (show INS Proteins) autobody positivity at the time of type 1 diabetes diagnosis
Members of the Ikaros (ZNFN1A1\; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.
ikaros family zinc finger protein 4
, zinc finger protein Eos
, zinc finger protein, subfamily 1A, 4 (Eos)
, zinc finger protein, subfamily 1A, 4
, zinc finger transcription factor Eos