anti-IQ Motif Containing GTPase Activating Protein 2 (IQGAP2) Antibodies

IQGAP2 encodes a member of the IQGAP family. Additionally we are shipping IQGAP2 Kits (8) and IQGAP2 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
IQGAP2 100360623  
IQGAP2 10788 Q13576
IQGAP2 544963 Q3UQ44
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Top anti-IQGAP2 Antibodies at antibodies-online.com

Showing 10 out of 62 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB Host: Rabbit Target Name: IQGAP2 Sample Tissue: Mouse Brain Antibody Dilution: 1ug/ml 100 μL 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB Western blot analysis in mouse testis tissue lysates (35ug/lane). 400 μL 2 to 3 Days
$515.63
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of IQGAP2 using anti-IQGAP2 antibody .  Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each  Lane was loaded with 50ug of sample under reducing conditions.   Lane 1: human Hela cell lysates,  Lane 2: human placenta tissue lysates, Lane 3: human HepG2 cell lysates,  Lane 4: mouse stomach tissue lysates.After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-IQGAP2 antigen affinity purified polyclonal antibody (Catalog # ) at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for IQGAP2 at approximately 181KD. The expected band size for IQGAP2 is at 181KD. 100 μg 4 to 6 Days
$240.00
Details
Human Mouse Un-conjugated IP, WB   200 μL 11 to 14 Days
$991.83
Details
Human Rabbit Un-conjugated ELISA, IHC, WB 200 μL 12 to 14 Days
$438.90
Details
Human Rabbit Un-conjugated WB Western blot analysis of extracts of various cell lines, using IQGAP2 antibody. 200 μL 12 to 14 Days
$438.90
Details
Human Mouse Un-conjugated ELISA, WB IQGAP2 monoclonal antibody (M01), clone 1B10 Western Blot analysis of IQGAP2 expression in HeLa . Detection limit for recombinant GST tagged IQGAP2 is approximately 0.03ng/ml as a capture antibody. 100 μg 11 to 12 Days
$440.00
Details
Human Goat Un-conjugated IHC   50 μg 11 to 16 Days
$688.29
Details
Human Rabbit Un-conjugated ELISA, WB IQGAP2 antibody western blot analysis in mouse testis tissue lysate. IQGAP2 antibody western blot analysis in mouse testis tissue lysate. 0.4 mL 2 to 3 Days
$452.38
Details
Cow Rabbit Un-conjugated WB   100 μL 11 to 14 Days
$551.83
Details

More Antibodies against IQGAP2 Interaction Partners

Xenopus laevis IQ Motif Containing GTPase Activating Protein 2 (IQGAP2) interaction partners

  1. Suppression of XIQGAP2 expression caused ectodermal lesions in the neurula stage embryos.

Human IQ Motif Containing GTPase Activating Protein 2 (IQGAP2) interaction partners

  1. Data suggest that CDC42 binding to Ex-domain of IQGAP2 releases Ex-domain at C-terminal region of GRD2 domain, facilitating IQGAP2 dimerization; this promotes allosteric changes in ras GTPase-activating protein binding site providing binding site for second CDC42; RAC1 binds only to apo-IQGAP2. (IQGAP2 = IQ motif containing GTPase activating protein-2; CDC42 = GTP-binding protein CDC42; RAC1 = Rac family small GTPase-1)

  2. IQGAP2 expression correlated positively with survivability, on the contrary, IQGAP3 expression levels correlated inversely with survivability

  3. The structural basis for Cdc42-induced dimerization of IQGAP1 and IQGAP2 has been uncovered.

  4. The most frequently identified and connected to preterm birth genes in the exome library were IGF1, ATM and IQGAP2.

  5. IQGAP2 TagSNP rs457717 (A/G) was not associated with Age-Related Hearing impairment in Han male Chinese population.

  6. Thus, these data identified IQGAP2 as a novel tumor suppressor for ovarian cancer to inhibit cell invasion through regulating Wnt/b-catenin signaling, and provided a new biomarker and potential therapeutic strategy for this disease.

  7. we identified IQGAP2 as a human and zebrafish podocyte gene product that is downregulated in microarray data sets from kidney biopsies of human patients with focal segmental glomerulosclerosis and minimal change nephrotic syndrome.

  8. Data show that IQ motif-containing GTPase-activating protein 2 (IQGAP2) expression is altered in colitis.

  9. IQGAP1, IQGAP2, and IQGAP3 have diverse roles in vertebrate physiology, operating in the kidney, nervous system, cardiovascular system, pancreas, and lung. (Review)

  10. Mammalian IQGAP proteins may play a role in cytokinesis by regulating the localization of key cytokinesis regulatory proteins to the contractile apparatus during mitosis.

  11. Low IQGAP2 expression was associated with hepatocellular carcinoma.

  12. The first IQ-motifs from IQGAP2 and IQGAP3 form transient interactions with calmodulin in the absence of calcium.

  13. observations strongly indicate that IQGAP2 is a surveillance type of tumour suppressor for prostate cancer

  14. increased IQGAP1 and/or decreased IQGAP2 contribute to the pathogenesis of human HCC.

  15. The top-ranked SNP, rs457717 for association with age-related hearing impairment(P-value 3.55 x 10(-7)), was localised in an intron of the IQ motif-containing GTPase-activating-like protein (IQGAP2).

  16. The gene for the putative rac1/cdc42 effector protein IQGAP2 was found in the PAR gene cluster at 5q13, flanked by PAR1 & encompassing PAR3. It functions as a GTP-dependent effector protein in thrombin-induced platelet cytoskeletal reorganization.

  17. silencing of IQGAP2 by promoter methylation may contribute to gastric cancer development.

Mouse (Murine) IQ Motif Containing GTPase Activating Protein 2 (IQGAP2) interaction partners

  1. The exacerbated mast cell responses observed in the absence of Dnmt3a were recapitulated or enhanced by treatment with the demethylating agent 5-aza-2'-deoxycytidine as well as by down-modulation of Dnmt1 expression. These effects were in part mediated by the dysregulated expression of the scaffold protein IQGAP2.

  2. found a hypomethylated region mapping to Iqgap2 (IQ motif-containing GTPase activating protein 2) and F2rl2

  3. Data show that complete loss of IQ motif-containing GTPase-activating protein 2 (IQGAP2) gene leads to protection from dextran sulfate sodium (DSS)-induced colitis.

  4. Transcript profiling identifies iqgap2(-/-) mouse as a model for advanced human hepatocellular carcinoma.

  5. Phosphoinositide module is defined by a C-terminal 105-107 amino acid region of which IQGAP1 and -2, but not IQGAP3, binds preferentially to phosphatidylinositol 3,4,5-trisphosphate (PtdInsP(3)).

  6. murine IQGAP2 selectively regulates the facilitated phase of hepatic fatty acid uptake both in vitro and in vivo

  7. Development of hepatocellular carcinoma in Iqgap2-deficient mice is Iqgap1 dependent.

IQGAP2 Antigen Profile

Protein Summary

This gene encodes a member of the IQGAP family. The protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility.

Gene names and symbols associated with IQGAP2

  • IQ motif containing GTPase activating protein 2 S homeolog (iqgap2.S) antibody
  • IQ motif containing GTPase activating protein 2 (IQGAP2) antibody
  • IQ motif containing GTPase activating protein 2 (iqgap2) antibody
  • ras GTPase-activating-like protein IQGAP1 (LOC100168908) antibody
  • IQ motif containing GTPase activating protein 2 (Iqgap2) antibody
  • 4933417J23Rik antibody
  • A630053O10 antibody
  • AI788777 antibody
  • IQGAP2 antibody
  • XIQGAP2 antibody

Protein level used designations for IQGAP2

IQ motif containing GTPase activating protein 2 , ras GTPase-activating-like protein IQGAP2-like , ras GTPase-activating-like protein IQGAP2

GENE ID SPECIES
398588 Xenopus laevis
461801 Pan troglodytes
479177 Canis lupus familiaris
100124996 Xenopus (Silurana) tropicalis
100168908 Acyrthosiphon pisum
100360623 Rattus norvegicus
100400958 Callithrix jacchus
100446817 Pongo abelii
100519536 Sus scrofa
10788 Homo sapiens
544963 Mus musculus
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