ISG15 Ubiquitin-Like Modifier Proteins (ISG15)

The protein encoded by ISG15 is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Additionally we are shipping ISG15 Antibodies (150) and ISG15 Kits (32) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ISG15 9636 P05161
ISG15 100038882 Q64339
Rat ISG15 ISG15 298693  
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Top ISG15 Proteins at antibodies-online.com

Showing 10 out of 29 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,465.26
Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,465.26
Details
Escherichia coli (E. coli) Human Un-conjugated 1 mg Log in to see 20 to 21 Days
$206.80
Details
Escherichia coli (E. coli) Human GST tag ISG15 Ubiquitin-Like Modifier (ISG15) (AA 2-157), (full length) protein (GST tag) 50 μg Log in to see 13 to 16 Days
$242.00
Details
Escherichia coli (E. coli) Human His tag   50 μg Log in to see 4 Days
$154.00
Details
Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 Days
$411.40
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$814.00
Details
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$2,339.33
Details
Escherichia coli (E. coli) Human Calmodulin (CaM)   50 μg Log in to see 2 to 3 Days
$261.54
Details

ISG15 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, , , , , , , , , ,
Mouse (Murine)
, ,

More Proteins for ISG15 Ubiquitin-Like Modifier (ISG15) Interaction Partners

Human ISG15 Ubiquitin-Like Modifier (ISG15) interaction partners

  1. IFN-gamma (show IFNG Proteins) increases free ISG15 levels in the cytoplasm and ISGylation in the nucleus and cytoplasm, but in a manner distinct between MCF-7 and MDA-MB-231cells.

  2. Hepatitis E virus may promote production of IFN-alpha (show IFNA Proteins)/beta and expression of ISG15 via ORF3 in the early stages, and increased ISG15 subsequently inhibited the production of IFN-alpha (show IFNA Proteins)/beta.

  3. ISG15 reduces miR-17-5p levels and thereby promotes Beclin-1 (show BECN1 Proteins)-mediated autophagy

  4. ISGylation is a ubiquitin-like modification that controls exosome release. ISGylation induction decreases microvesicular body numbers and impairs exosome secretion. Specifically, ISGylation of the MVB protein TSG101 (show TSG101 Proteins) induces its aggregation and degradation, being sufficient to impair exosome secretion.

  5. The species-specific gain-of-functi (show USP18 Proteins)on in antiviral immunity ob (show IFNA Proteins)served in ISG15 deficiency is explained by the requirement of ISG15 to sustain USP18 levels in humans.

  6. HIV-1 IIIB infection of myeloid ThP-1 cells also reduced the IFN-alpha (show IFNA Proteins)-mediated induction of the anti-viral gene, ISG15, but not MxA (show MX1 Proteins), revealing a functional consequence of this HIV-1-mediated immune evasion strategy.

  7. DNA damage induces ISG15 conjugation to p53 (show TP53 Proteins) and this modification markedly enhances the binding of p53 (show TP53 Proteins) to the promoters of its target genes as well as of its own gene by promoting phosphorylation and acetylation.

  8. Studied foot-and-mouth disease virus (FMDV) Lbpro targeting of ISG15. Show a previously undescribed mechanism by which viruses interfere with the ubiquitin and ubiquitin-like systems.

  9. ISG15 is able to trigger IFN-gamma (show IFNG Proteins) production and other signaling pathways suggesting it is a potential cytokine that could interact with still unknown receptors. (Review)

  10. ISG15 induces cancer cell apoptosis by disrupting the NF-kappaB (show NFKB1 Proteins) signaling pathway. This study highlighted a novel role of ISG15 in tumor suppression.

Cow (Bovine) ISG15 Ubiquitin-Like Modifier (ISG15) interaction partners

  1. Data suggest that ISG15 is involved in early blastocyst/embryo development; ISG15 appears to regulate gene expression in developing blastocyst; specifically, ISG15 is required for up-regulation of IFNT expression in blastocyst development. (ISG15 = ubiquitin-like protein ISG15, interferon-stimulated gene 15 protein; IFNT = interferon-tau)

  2. ISG 15 gene expression is upregulated during 16-18 days of pregnancy and could be used as an early pregnancy marker in dairy cows, especially in heifers.

  3. ISG15, UBE1l (show UBA7 Proteins) and UBCH8 (show UBE2E2 Proteins) genes are significantly upregulated in the artificially inseminated pregnant cows.

  4. Data indicate that the expression profiles of ISG15, MX1 (show MX1 Proteins), MX2 (show MX2 Proteins), and OAS1 (show OAS1 Proteins) could be a useful diagnostic biomarker of gestation.

  5. ISG15 is an antiviral and inducible protein in bovine immunodeficiency virus infected bovin lung cells.

  6. ISG15 and conjugated proteins were expressed in corpus luteum of both cyclic and pregnant cows regardless of pregnancy status and were upregulated during early pregnancy

  7. interferon-stimulated protein (show ISG20 Proteins)(ISG15) was localized throughout the endometrium on day 18-23 of bovine pregnancy and was specifically localized to organelles and compartments of endometrial epithelial cells and stromal cells

  8. rbovISG15 is unstable over time in storage & dialysis. In vivo, conjugation of ISG15 to targeted proteins occurs inside the cell.

Zebrafish ISG15 Ubiquitin-Like Modifier (ISG15) interaction partners

  1. Overall, these data demonstrate the antiviral effect of a fish ISG15 protein, revealing the conservation among vertebrates of an ISGylation mechanism likely directed against viruses.

Pig (Porcine) ISG15 Ubiquitin-Like Modifier (ISG15) interaction partners

  1. NSP2 (show RTN2 Proteins) of porcine reproductive and respiratory syndrome virus inhibits the antiviral function of ISG15.

  2. Results report identification and cloning of the ISG15 and ISG43 (show USP18 Proteins) genes in pig.

Mouse (Murine) ISG15 Ubiquitin-Like Modifier (ISG15) interaction partners

  1. ISGylation is a ubiquitin-like modification that controls exosome release. ISGylation induction decreases microvesicular body numbers and impairs exosome secretion. Specifically, ISGylation of the MVB protein TSG101 (show TSG101 Proteins) induces its aggregation and degradation, being sufficient to impair exosome secretion.

  2. Murine Isg15 does not control Usp18 (show USP18 Proteins) accumulation and IFN-alpha (show IFNA Proteins)/beta signaling.

  3. Extracellular ISG15 signals cytokine secretion through the LFA-1 (show ITGAL Proteins) integrin receptor (CD11a (show ITGAL Proteins)/CD18 (show ITGB2 Proteins)) in natural killer cells.

  4. results demonstrate that ISG15 governs the dynamic functionality of mitochondria, specifically, OXPHOS and mitophagy, broadening its physiological role as an antiviral agent.

  5. Loss of ISG15 expression and type I IFN signaling have transient effects on bacterial burden during M. tuberculosis infection in mice

  6. ISG15 acts as an immunomodulator in the cornea and plays a critical role in controlling fungal keratitis.

  7. USP18 (show USP18 Proteins)'s ISG15 specificity is mediated by a small interaction interface.

  8. Posttranslational protein modification by ISG15 plays an important role in antiviral defense

  9. These studies provide evidence, ISG15 is elevated following TBI in mice, preceding MLCK elevation, development of BBB disruption, and cerebral edema.

  10. Kruppel-like factor 9 (KLF9 (show KLF9 Proteins)) is a haploinsufficient tumor suppressor in the ApcMin/+ mouse colon by suppressing expression of ISG15, an apoptosis-inhibiting cytokine.

Horse (Equine) ISG15 Ubiquitin-Like Modifier (ISG15) interaction partners

  1. The expression of interferon-stimulated protein 15 kDa (ISG15) during pregnancy is described.[ISG15]

ISG15 Protein Profile

Protein Summary

The protein encoded by this gene is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted.

Gene names and symbols associated with ISG15

  • ISG15 ubiquitin-like modifier (ISG15)
  • ISG15 ubiquitin-like modifier (isg15)
  • ISG15 ubiquitin-like modifier (Isg15)
  • G1p2 protein
  • hUCRP protein
  • IFI15 protein
  • IGI15 protein
  • IP17 protein
  • Irfp protein
  • ISG15 protein
  • ISG17 protein
  • ISG17/UCRP protein
  • si:rp71-1c23.2 protein
  • UCRP protein

Protein level used designations for ISG15

interferon, alpha-inducible protein (clone IFI-15K) , interferon-induced 17-kDa/15-kDa protein , interferon-stimulated protein, 15 kDa , ubiquitin cross-reactive protein , ubiquitin-like protein ISG15 , boUCRP , interferon-stimulated gene product 17 , ISG15 ubiquitin-like modifier , si:rp71-1c23.2 , zfISG15 , interferon stimulated gene, 15 kDa , interferon, alpha-inducible protein , interferon-induced 17 kDa protein , interferon-stimulated protein 15 , interferon-induced 15 kDa protein , interferon-induced 15-KDa protein , interferon-stimulated protein (15 kDa) , interferon stimulated gene 17 , interferon-stimulated protein 17/ubiquitin cross-reactive protein

GENE ID SPECIES
9636 Homo sapiens
281871 Bos taurus
465390 Pan troglodytes
558956 Danio rerio
700141 Macaca mulatta
100145895 Sus scrofa
100174787 Felis catus
100038882 Mus musculus
298693 Rattus norvegicus
100855667 Canis lupus familiaris
100354504 Oryctolagus cuniculus
443057 Ovis aries
102169982 Capra hircus
100066364 Equus caballus
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