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LIM homeobox transcription factor; involved in topographic organization of motor neurons.
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lack both Isl1 (show ISL1 Proteins) and Isl2, large numbers of motor neurons exited the neural tube, even prior to the appearance of boundary cap cells at the ventral exit points
X-ray crystal- and small-angle x-ray scattering-derived solution structures of an Lhx4 (show LHX4 Proteins).Isl2 complex exhibit many similarities with that of Lhx3 (show LHX3 Proteins).Isl1 (show ISL1 Proteins); structural differences supported by mutagenic studies reveal differences in the mechanisms of binding.
Isl2 specifies RGC laterality by repressing an ipsilateral pathfinding program unique to VTC RGCs and involving Zic2 (show ZIC2 Proteins) and EphB1 (show EPHB1 Proteins). This genetic hierarchy controls binocular vision
The second wave of expression at E12.5 includes Lhx3 (show LHX3 Proteins), 5, 9, Isl2, and Lmx1b (show LMX1B Proteins) in the differentiating sensory epithelia with cellular specificities.
Successful purification and crystallization of an engineered complex comprising the LIM (show PDLIM5 Proteins) domains of motor neuron protein Lhx4 (show LHX4 Proteins) and the Lim (show PDLIM5 Proteins) binding domain of Isl2 (islet 2 protein) are reported.
Data describe how the dosage of LIM homeodomain (show LHX2 Proteins) proteins Isl1 (show ISL1 Proteins) and Isl2 and LIM (show PDLIM5 Proteins)-only protein Lmo4 (show LMO4 Proteins) influences the assembly and function of complexes involved in the generation of spinal motor neurons (MNs (show GYPE Proteins)) and V2a interneurons (INs (show INS Proteins)).
Experiments in Isl2/EphA3 (show EPHA3 Proteins) knock-in mice test the interactions between effects of molecular labels and correlated activity during the development of neural connectivity.
The broad expression of Isl-2 gene in tissues during embryogenesis and adult development suggests that it may be involved in both differentiation and maintenance of these tissues and might play an important role.
Isl2a is expressed in the lateral posterior mesoderm prior to angioblast migration. Isl2a-deficient angioblasts show disorganized migration to the midline to form axial vessels. Its expression is negatively regulated by Notch (show NOTCH1 Proteins) activity. It positively regulates flt4 (show FLT4 Proteins), a VEGF-C (show VEGFC Proteins) receptor repressed by Notch (show NOTCH1 Proteins) during angiogenesis. Isl2a may be an intermediate between Notch (show NOTCH1 Proteins) signaling and genetic programs controlling angioblasts.
Prdm14 regulates caudal rimary axon outgrowth through activation of islet2 expression.
primary motoneuron subtypes are likely to be specified by factors that act in parallel to or upstream of islet1 (show ISL1 Proteins) and islet2
LIM homeobox transcription factor; involved in topographic organization of motor neurons
insulin gene enhancer protein ISL-2
, islet 2
, domesticus (clone 1.6 kB) islet-2
, ISL2 transcription factor, LIM/homeodomain, (islet-2)
, insulin related protein 2 (islet 2)
, insulin gene enhancer protein isl-2
, insulin gene enhancer protein isl-2a