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LIM homeobox transcription factor; involved in topographic organization of motor neurons. Additionally we are shipping ISL LIM Homeobox 2 Antibodies (72) and ISL LIM Homeobox 2 Kits (1) and many more products for this protein.
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Experiments in Isl2/EphA3 knock-in mice test the interactions between effects of molecular labels and correlated activity during the development of neural connectivity.
The broad expression of Isl-2 gene in tissues during embryogenesis and adult development suggests that it may be involved in both differentiation and maintenance of these tissues and might play an important role.
Isl2b regulates anterior second heart field development in zebrafish.
Isl2a is expressed in the lateral posterior mesoderm prior to angioblast migration. Isl2a-deficient angioblasts show disorganized migration to the midline to form axial vessels. Its expression is negatively regulated by Notch activity. It positively regulates flt4, a VEGF-C receptor repressed by Notch during angiogenesis. Isl2a may be an intermediate between Notch signaling and genetic programs controlling angioblasts.
Prdm14 regulates caudal rimary axon outgrowth through activation of islet2 expression.
Results show that PlexinA4, a transmembrane protein known to be a co-receptor for class III semaphorins, acts downstream of Islet2 to promote branching of the peripheral axons of the primary sensory neurons.
primary motoneuron subtypes are likely to be specified by factors that act in parallel to or upstream of islet1 and islet2
LIM homeobox transcription factor; involved in topographic organization of motor neurons
ISL2 transcription factor, LIM/homeodomain, (islet-2)
, insulin gene enhancer protein ISL-2
, insulin related protein 2 (islet 2)
, insulin gene enhancer protein isl-2
, insulin gene enhancer protein isl-2a
, domesticus (clone 1.6 kB) islet-2
, insulin gene enhancer protein isl-2b
, insulin gene enhancer protein isl-3