Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
The adult colon epithelium contains 3 differentiated cell types that arise from a multipotent stem cell. Additionally we are shipping ICT1 Antibodies (65) and ICT1 Kits (5) and many more products for this protein.
Showing 8 out of 10 products:
ICT1 overexpression notably predicted poor prognosis of gastric cancer patients.
Study demonstrates that ICT1 overexpression correlates with malignant clinical features and poor prognosis of hepatocellular carcinoma (HCC (show FAM126A Proteins)) patients. Functionally, ICT1 promotes proliferation, cell cycle progression and inhibits apoptosis of HCC (show FAM126A Proteins) cells. ICT1 regulates the expressions of CDK1 (show CDK1 Proteins), cyclin B1 (show CCNB1 Proteins), Bcl-2 (show BCL2 Proteins) and Bax (show BAX Proteins), and is directly targeted by microRNA-134 (miR (show MLXIP Proteins)-134) in HCC (show FAM126A Proteins) cells.
ICT1 may play a crucial role in promoting gastric cancer proliferation in vitro.
The results provide direct evidence that localized feedbacks on Fat4-Ds1 complexes can give rise to planar cell polarity.
our preliminary study reveals the important role of ICT1 in NSCLC cells that knockdown of ICT1 significantly suppressed cell proliferation, arrested cell cycle though altering expression cell cycle regulators, and promoted cell apoptosis.
ICT1 knockdown significantly inhibited cell proliferation and migration, led to G2/M phase cell-cycle arrest, and triggered apoptosis via the intracellular AMPKa, SAPK (show MAPK9 Proteins)/JNK (show MAPK8 Proteins), and PARP signaling pathways.
ICT1 was significantly upregulated in diffuse large B-cell lymphoma tissues (DLBCL) and correlated with poor survival. Knockdown of ICT1 remarkably induced cell cycle G0/G phase arrest and apoptosis in DLBCL cells.
ICT1 knockdown altered the expression of apoptosis- or cell cyclerelated proteins such as Bcl-2 (show BCL2 Proteins), caspase-3 (show CASP3 Proteins), CDK1 (show CDK1 Proteins), CDK2 (show CDK2 Proteins) and cyclin B.
ICT1 may be essential for hydrolysis of prematurely terminated peptidyl-tRNA moieties in stalled mitoribosomes.
Because ICT1 is essential in human cells, these results suggest that ribosome rescue activity in mitochondria is required in humans
solution structure of the catalytic domain of the ICT1 protein that lacks an N-terminal mitochondrial targeting signal and an unstructured C-terminal basic-residue-rich extension
The adult colon epithelium contains 3 differentiated cell types that arise from a multipotent stem cell. Deviation from the normal maturation pathway by neoplastic transformation is thought to initiate in stem cells or their early descendants. One potential marker is ICT1 whose mRNA and protein were more highly expressed in undifferentiated than in differentiated cells.
immature colon carcinoma transcript 1
, Immature colon carcinoma transcript 1
, Immature colon carcinoma transcript 1 protein homolog
, Peptidyl-tRNA hydrolase ICT1, mitochondrial
, digestion substraction 1
, immature colon carcinoma transcript 1 protein
, peptidyl-tRNA hydrolase ICT1, mitochondrial
, immature colon carcinoma transcript 1 protein homolog