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Serves to link two monomer units of either IgM or IgA.
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Results show that ID1 (show ID1 Proteins), ID3 (show ID3 Proteins) and IGJ genes are highly expressed in adult B-ALL and correlate with poor prognosis in Hispanic patients.
TLR2 ligands induce CCR9 and CCR10 expression by circulating B-cells and increase their chemotaxis. TLR2 stimulation also induced J chain and IgA production demonstrating the induction of mucosal-like antibody secreting cells.
Data show that Crlz1 (show UTP3 Proteins) increased the IgJ enhancer activity due to its CBF sites, as verified by both the absence of Crlz1 (show UTP3 Proteins) effect on the CBF-site mutated IgJ enhancer and the presence of transcriptional synergy between Crlz1 (show UTP3 Proteins) and CBFbeta (show CBFB Proteins).
identifies the HSS3/4 enhancer of Crlz1 (show UTP3 Proteins)-IgJ locus as another target of EBG in early developmental stage of B cells
H3 and H4 histones toward the chromatin of the Crlz1 (show UTP3 Proteins) gene are found to be hyperacetylated, especially on H3, in the pre-B cells, whereas those toward the chromatin of the IgJ gene are found to be hyperacetylated in the plasma cells
Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.
immunoglobulin J chain
, mu- and alpha-immunoglobulin-associated J chain
, IgJ chain
, J chain
, immunoglobulin joining gene (not J region)