Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal.
Showing 10 out of 38 products:
Human Polyclonal Importin 8 Primary Antibody for ICC, IF - ABIN4325788
Wu, Wang, Young, Lai, Li: Proteome-wide identification of novel binding partners to the oncogenic fusion gene protein, NPM-ALK, using tandem affinity purification and mass spectrometry. in The American journal of pathology 2009
Show all 2 Pubmed References
Human Polyclonal Importin 8 Primary Antibody for IHC (p), IHC - ABIN249599
Görlich, Dabrowski, Bischoff, Kutay, Bork, Hartmann, Prehn, Izaurralde: A novel class of RanGTP binding proteins. in The Journal of cell biology 1997
the findings of the present study provided novel insights into the control of IPO8 transcription, and may enhance understanding regarding RUNX2 (show RUNX2 Antibodies) regulatory mechanisms in osteoblast differentiation, bone development, and degenerative bone disease.
Our studies also suggest that nuclear entry is important for the prooncogenic activity of eIF4E (show EIF4E Antibodies), at least in this context. These findings position nuclear trafficking of eIF4E (show EIF4E Antibodies) as a critical step in its regulation and position the importin 8-eIF4E (show EIF4E Antibodies) complex as a novel therapeutic target.
importin alpha8 functions as a cNLS receptor with distinct cargo specificity, and that heterodimerization by importin alpha8 is a novel regulatory mode of cNLS binding, in addition to the autoinhibitory regulation by the importin beta (show KPNB1 Antibodies) binding domain.
Knockdown of IPO8 reduced the amount of nuclear p65 (show GORASP1 Antibodies) following TNF (show TNF Antibodies) stimulation. IPO8 binding to p65 (show GORASP1 Antibodies) is NLS (show ALDH1A2 Antibodies) independent.
TGF-beta (show TGFB1 Antibodies)-induced and basal state spontaneous nuclear import of Smad4 (show SMAD4 Antibodies) require importin 7 (show IPO7 Antibodies) and 8.
IPO8 is the most accurate reference gene for clinical lung specimens.
Study provides evidence that Imp8 is required for cytoplasmic miRNA-guided gene silencing and affects nuclear localization of Ago proteins.
Importin 8 plays a critical role in mediating the cytoplasm-to-nucleus transport of mature miRNAs. IPO8-mediated nuclear transport of mature miRNAs is also dependent on the association of IPO8 with the Argonaute 2 (show EIF2C2 Antibodies) complex.
The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. This protein binds to the nuclear pore complex and, along with RanGTP and RANBP1, inhibits the GAP stimulation of the Ran GTPase. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, RAN binding protein 8
, ran-binding protein 8
, ATP-binding cassette, sub-family C (CFTR/MRP), member 10
, oocyte maturation 1