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The protein encoded by INPP5E is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. Additionally we are shipping INPP5E Antibodies (19) and many more products for this protein.
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The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause Joubert syndrome\; a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation and various associated ciliopathies that include retinal dystrophy, nephronophthisis, liver fibrosis and polydactyly.
72 kDa inositol polyphosphate 5-phosphatase
, inositol polyphosphate-5-phosphatase, 72 kDa
, phosphatidylinositol 4,5-bisphosphate 5-phosphatase
, phosphatidylinositol polyphosphate 5-phosphatase type IV
, phosphatidylinositol-4,5-bisphosphate 5-phosphatase
, 5-phosphatase that induces arborization
, inositol polyphosphate 5-phosphatase
, phosphatidylinositol (4,5) bisphosphate 5-phosphatase
, inositol polyphosphate-5-phosphatase E
, peptidase (mitochondrial processing) alpha