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IGF2BP1 encodes a member of the insulin-like growth factor 2 mRNA-binding protein family.
Showing 10 out of 72 products:
Human Polyclonal IGF2BP1 Primary Antibody for ELISA, WB - ABIN4321629
Noubissi, Goswami, Sanek, Kawakami, Minamoto, Moser, Grinblat, Spiegelman: Wnt signaling stimulates transcriptional outcome of the Hedgehog pathway by stabilizing GLI1 mRNA. in Cancer research 2009
Human Polyclonal IGF2BP1 Primary Antibody for FACS, IHC (p) - ABIN654423
Zhou, Rong, Zhang, Aloysius, Pan, Liang: Insulin-like growth factor II mRNA binding protein 1 modulates Rev-dependent human immunodeficiency virus type 1 RNA expression. in Virology 2009
Show all 3 Pubmed References
Human Polyclonal IGF2BP1 Primary Antibody for IHC, IHC (p) - ABIN4891518
Hsieh, Chou, Chen, Tseng: IMP1 promotes choriocarcinoma cell migration and invasion through the novel effectors RSK2 and PPME1. in Gynecologic oncology 2013
IGF2BP1 mediates posttranscriptional loss of BCL11A (show BCL11A Antibodies) in cultured human adult erythroblasts
HCG11 exerted its effect on Hepatocellular carcinoma (HCC (show FAM126A Antibodies))via interaction with IGF2BP1, leading to activation of MAPK (show MAPK1 Antibodies) signaling, which eventually promoted the progression of HCC (show FAM126A Antibodies)
miR (show MLXIP Antibodies)-98-5p, downregulated in HCC (show FAM126A Antibodies), inhibits proliferation while inducing apoptosis in HCC (show FAM126A Antibodies) LM3 cells, partly at least, through directly targeting IGF2BP1
Findings suggest a MicroRNA-140-5p (miR (show MLXIP Antibodies)-140-5p)-Insulin like growth factor 2 mRNA binding protein 1 (IGF2BP1) regulatory circuit for CC pathogenesis, and miR (show MLXIP Antibodies)-140-5p may be a potential target for CC therapy.
Our studies provide insights into a molecular mechanism that the positive function of IMP1 (show IMPA1 Antibodies) to inhibit breast tumor growth and metastasis
The regions encoding 71 microRNAs (miRs) were deleted in at least 25% of tumor specimens. Five of these recurrently deleted miRs targeted the insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) gene product, and a correlating 100-fold upregulation of IGF2BP1 mRNA was seen in tumor specimens
Insight into molecular interactions between CRD-BP and MITF (show MITF Antibodies) mRNA.
IGF2BP1 indirectly potentiates ETV6 (show ETV6 Antibodies)/RUNX1 (show RUNX1 Antibodies)-RAC1-STAT3 (show STAT3 Antibodies) signaling axis by sustaining appropriate ETV6 (show ETV6 Antibodies)/RUNX1 (show RUNX1 Antibodies) and STAT3 (show STAT3 Antibodies) transcript levels in REH (show CES1 Antibodies) cells.
The findings indicate that the tumor-suppressive roles of the let-7 family are antagonized by a potent and self-promoting triangle consisting of IGF2BP1 (potentially all IGF2BPs), LIN28B and HMGA2.
The results from this study demonstrate the potential importance of the two-stem-loop motif as a target region for the inhibition of the CRD-BP-GLI1 (show GLI1 Antibodies) RNA interaction and Hedgehog (show SHH Antibodies) signaling pathway.
This study showed that Zipcode binding protein 1 (ZBP1) is an mRNA-binding protein that regulates the local translation of proteins, including actin, in the growth cone and is required for Shh (show SHH Antibodies)-mediated axon guidance.
The tumor-suppressive role of stromal IMP1 (show IMPA1 Antibodies) and its ability to modulate protumorigenic factors suggest that IMP1 (show IMPA1 Antibodies) status is important for the initiation and growth of epithelial tumors
High CRD-BP expression is associated with Breast Tumor.
Results identify IGF2BP1 (show B4GALNT2 Antibodies) as a critical translational regulator of cIAP1 (show BIRC2 Antibodies)-mediated apoptotic resistance in rhabdomyosarcoma.
This study demonstrate that ZBP1 (show ZBP1 Antibodies) and the phosphorylation of ZBP1 (show ZBP1 Antibodies) are required for attractive guidance of cortical neurons, and appropriate filopodial dynamics.
IMP1 (show IMPA1 Antibodies) plays a role in regulating the packaging of MLV genomic RNA and can be used for improving production of retroviral vectors
WAP-CRD-BP mice are a novel model for mammary neoplasia and might provide insights into human breast cancer biology.
IMP-1 (show IMPA1 Antibodies) associates with HuD (show ELAVL4 Antibodies) and G3BP-1 (show G3BP1 Antibodies) proteins in an RNA-dependent manner and binds directly to tau mRNA. We also show an RNA-dependent association between G3BP-1 (show G3BP1 Antibodies) and HuD (show ELAVL4 Antibodies) proteins
Two KH domains of CRD-BP are required for efficient binding to oncogenic mRNAs and for granule formation in zebrafish embryos.
This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for this gene.
insulin-like growth factor 2 mRNA binding protein 1
, IGF-II mRNA-binding protein 1
, IGF2 mRNA-binding protein 1
, VICKZ family member 1
, insulin-like growth factor 2 mRNA-binding protein 1
, zip code-binding protein 1
, zipcode-binding protein 1
, coding region determinant-binding protein
, coding region determinant binding protein
, insulin-like growth factor 2, binding protein 1
, zipcode binding protein 1
, B-actin zipcode-binding protein 1
, insulin-like growth factor 2 binding protein 1
, zipcode-binding protein-1