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Function as an agonist of NF-kappa B activation through the orphan IL-1-receptor-related protein 2. Additionally we are shipping Interleukin 1 Family, Member 6 Antibodies (82) and Interleukin 1 Family, Member 6 Kits (14) and many more products for this protein.
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The data identify a novel role for IL-36 signaling in colonic inflammation and indicate that the IL-36R (show IL1RL2 Proteins) pathway may represent a novel target for therapeutic intervention.
IL-1 (show IL1A Proteins) and IL-36 have roles as inflammatory mediators in pustular psoriasis in a mouse model
An essential role of C/EBPbeta (show CEBPB Proteins) in the regulation of the Il36A gene via the proximal half-CRE*C/EBP (show CEBPA Proteins) element in response to inflammatory stimuli.
IL-36alpha acts as a pro-inflammatory cytokine in the lungs independent of both IL-1alpha and IL-1beta (show IL1B Proteins).
Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36alpha, IL-36beta, and IL-36gamma) or antagonist (IL-36Ra) activity
A critical role of IL-36R (show IL1RL2 Proteins) ligands in the interface between innate and adaptive immunity, leading to the stimulation of T helper responses.
Transcripts for IL-1F5, -1F6, -1F8, and -1F9 are all significantly increased in the involved skin of bitransgenic mice compared with their monotransgenic controls.
IL-1F6 can be externalized via a stimulus-coupled mechanism comparable to that used by IL-1beta (show IL1B Proteins)
IL-36-mediated IL-6 (show IL6 Proteins) and CXCL8 (show IL8 Proteins) production in human lung fibroblasts and bronchial epithelial cells may be involved in pulmonary inflammation especially caused by bacterial or viral infections.
Data suggest that interleukin-36alpha (IL-36alpha) plays an important role in the pathophysiology of inflammation and fibrosis in the pancreas via an autocrine function.
Increased Expression of Interleukin-36 is associated with Inflammatory Bowel Disease.
Study shows that plasma concentrations of IL-36alpha and IL-36gamma are overexpressed in active systemic lupus erythematosus patients and that IL-36alpha has a substantial pro-inflammatory effect through regulation of IL-6 (show IL6 Proteins) and CXCL8 (show IL8 Proteins) production.
IL36A-IL36R (show IL1RL2 Proteins) axis is modulated in patients with primary Sjogren's syndrome.
Results show that IL-36alpha expression may play a pivotal role in determining the prognosis of hepatocellular carcinoma (HCC (show FAM126A Proteins)).
The novel cytokine interleukin-36alpha is expressed in psoriatic and rheumatoid arthritis synovium.
Expression of IL-1F6 is increased in human plaque psoriasis skin and in the lesional skin of transgenic mice compared with monotransgenic littermates.
Function as an agonist of NF-kappa B activation through the orphan IL-1-receptor-related protein 2. Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), that is present in epithelial barriers and takes part in local inflammatory response.
interleukin 1 family, member 6
, interleukin-1 family member 6
, interleukin 1 family, member 6 (epsilon)
, interleukin 1 family, member 6 (epsilon)-like
, FIL1 epsilon
, IL-1 epsilon
, interleukin 1 family, member 9
, interleukin-1 epsilon
, interleukin-1 homolog 1
, interleukin-36 alpha
, IL-1F6 (FIL-1-epsilon)
, interleukin 1, epsilon