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Function as an agonist of NF-kappa B activation through the orphan IL-1-receptor-related protein 2. Additionally we are shipping Interleukin 1 Family, Member 6 Antibodies (69) and Interleukin 1 Family, Member 6 Kits (11) and many more products for this protein.
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The data identify a novel role for IL-36 signaling in colonic inflammation and indicate that the IL-36R (show IL1RL2 Proteins) pathway may represent a novel target for therapeutic intervention.
IL-1 (show IL1A Proteins) and IL-36 have roles as inflammatory mediators in pustular psoriasis in a mouse model
An essential role of C/EBPbeta (show CEBPB Proteins) in the regulation of the Il36A gene via the proximal half-CRE*C/EBP (show CEBPA Proteins) element in response to inflammatory stimuli.
IL-36alpha acts as a pro-inflammatory cytokine in the lungs independent of both IL-1alpha and IL-1beta (show IL1B Proteins).
Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36alpha, IL-36beta, and IL-36gamma) or antagonist (IL-36Ra) activity
A critical role of IL-36R (show IL1RL2 Proteins) ligands in the interface between innate and adaptive immunity, leading to the stimulation of T helper responses.
Transcripts for IL-1F5, -1F6, -1F8, and -1F9 are all significantly increased in the involved skin of bitransgenic mice compared with their monotransgenic controls.
IL-1F6 can be externalized via a stimulus-coupled mechanism comparable to that used by IL-1beta (show IL1B Proteins)
Data suggest that interleukin-36alpha (IL-36alpha) plays an important role in the pathophysiology of inflammation and fibrosis in the pancreas via an autocrine function.
Increased Expression of Interleukin-36 is associated with Inflammatory Bowel Disease.
Study shows that plasma concentrations of IL-36alpha and IL-36gamma are overexpressed in active systemic lupus erythematosus patients and that IL-36alpha has a substantial pro-inflammatory effect through regulation of IL-6 (show IL6 Proteins) and CXCL8 (show IL8 Proteins) production.
IL36A-IL36R (show IL1RL2 Proteins) axis is modulated in patients with primary Sjogren's syndrome.
Results show that IL-36alpha expression may play a pivotal role in determining the prognosis of hepatocellular carcinoma (HCC (show FAM126A Proteins)).
The novel cytokine interleukin-36alpha is expressed in psoriatic and rheumatoid arthritis synovium.
Expression of IL-1F6 is increased in human plaque psoriasis skin and in the lesional skin of transgenic mice compared with monotransgenic littermates.
A functional IL-6 (show IL6 Proteins) polymorphism has been weakly associated with level of peak bone mineral density and the rate of forearm trabecular postmenopausal bone loss in a cohort of women.
Function as an agonist of NF-kappa B activation through the orphan IL-1-receptor-related protein 2. Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), that is present in epithelial barriers and takes part in local inflammatory response.
interleukin 1 family, member 6
, interleukin-1 family member 6
, interleukin 1 family, member 6 (epsilon)
, interleukin 1 family, member 6 (epsilon)-like
, FIL1 epsilon
, IL-1 epsilon
, interleukin 1 family, member 9
, interleukin-1 epsilon
, interleukin-1 homolog 1
, interleukin-36 alpha
, IL-1F6 (FIL-1-epsilon)
, interleukin 1, epsilon