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The protein encoded by IL22RA2 is a soluble class II cytokine receptor. Additionally we are shipping IL22RA2 Antibodies (90) and IL22RA2 Kits (19) and many more products for this protein.
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suggest that the human IL-22BP isoforms have distinct spatial and temporal roles and coordinately fine-tune IL-22 (show IL22 Proteins)-dependent STAT3 (show STAT3 Proteins) responses in tissues as a type of rheostat.
thia study shows shows that nonaffected skin of psoriasis patients displays lower expression of IL-22BP than skin of healthy controls, and that the strong IL-22 (show IL22 Proteins) increase in lesional psoriatic skin is accompanied by a moderate induction of IL-22BP
The deletion of IFNGR1 (show IFNGR1 Proteins) causes complete IFN-gammaR1 deficiency. Despite the deletion ending very close to the IL22RA2 gene, it does not appear to affect IL22RA2 transcription.
IL-22BP is produced by eosinophils in the gut (show GUSB Proteins) and blocks IL-22 (show IL22 Proteins) protective actions in colitis.
Through a combined approach including genetic and immunological investigation in an animal model and large-scale association studies of patients with multiple sclerosis (MS), IL-22RA2 is established as an MS risk gene.
The IL-22R (show IL22RA1 Proteins) and IL-10R2 (show IL10RB Proteins) binding sites are juxtaposed on adjacent IL-22 (show IL22 Proteins) surfaces contributed mostly by helices A, D, and F and loop AB.
Crystallization and preliminary X-ray diffraction results of the IL-22-IL-22 (show IL22 Proteins) binding protein (IL-22BP) complex are described.
Comparison of IL-22 (show IL22 Proteins)/IL-22BP and IL-22 (show IL22 Proteins)/IL-22R1 crystal structures shows that both receptors display an overlapping IL-22 (show IL22 Proteins) binding surface, which is consistent with the inhibitory role played by IL-22 (show IL22 Proteins) binding protein.
Polymorphisms in IL22RA1 (show IL22RA1 Proteins) are associated with severe CRS (show CARS Proteins).
Il22bp-deficient mice were more susceptible to acute liver damage in models of acute liver damage induced by ischemia reperfusion and acetaminophen administration. IL-22BP plays a protective role in acute liver damage, via controlling IL-22 (show IL22 Proteins)-induced Cxcl10 (show CXCL10 Proteins) expression.
IL-22BP promotes bacterial uptake into Peyer's patches by influencing follicle-associated epithelium gene expression and function.
IL22RA2 KO displayed a less severe EAE course, less demyelination and less infiltration of immune cells in the CNS.
the IL-22 (show IL22 Proteins)-IL-22BP axis critically regulates intestinal tissue repair and tumorigenesis in the colon
cloning and characterization; gene encodes a protein of 230 amino acids that share 67.1% amino-acid sequence identity with human IL-22 (show IL22 Proteins) binding protein; upregulated by LPS (show TLR4 Proteins) stimulation in monocytes
The protein encoded by this gene is a soluble class II cytokine receptor. This protein has been shown to specifically bind to interleukin 22 (IL22), block the interaction of IL22 with its cell surface receptor, and thus inhibit IL22 activity. This protein functions as an IL22 antagonist, and may be important in the regulation of inflammatory response. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
interleukin 22-binding protein
, interleukin 22 receptor, alpha 2
, interleukin 22-binding protein-like
, cytokine receptor class-II member 10
, cytokine receptor family type 2, soluble 1
, interleukin-22 receptor subunit alpha-2
, IL-22 receptor subunit alpha-2
, cytokine receptor family II soluble 1
, interleukin-22-binding protein