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IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes.
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Mouse (Murine) IL31 ELISA Kit for Sandwich ELISA - ABIN415707
Yamada, Ueda, Nakamura, Kanayama, Tamura, Hashimoto, Matsumoto, Ishii: Immediate-type allergic and protease-mediated reactions are involved in scratching behaviour induced by topical application of Dermatophagoides farinae extract in NC/Nga mice. in Experimental dermatology 2017
Show all 2 Pubmed References
Human IL31 ELISA Kit for Sandwich ELISA - ABIN417593
Vangerven, Delrue, Brugman, Cosaert: A new therapeutic approach to accidental intra-arterial injection of thiopentone. in British journal of anaesthesia 1989
Human IL31 ELISA Kit for Sandwich ELISA - ABIN625326
Zeng, Zhang, Gao, Wang, Yu, Zhou, Xi: Clinical Significance of Serum Interleukin-31 and Interleukin-33 Levels in Patients of Endometrial Cancer: A Case Control Study. in Disease markers 2016
review: in-depth overview of the role of IL-31 in chronic skin diseases and the possible diagnostic and therapeutic applications in the management of these diseases
Obtained results, as well as literature data, show that lower concentration of IL-31 in patients' serum may be correlated with its role in JAK (show JAK3 ELISA Kits)/STAT (show STAT1 ELISA Kits) signaling pathway which is involved in development of autoimmune blistering disease
IL-31 gene polymorphisms were tightly associated with dilated cardiomyopathy susceptibility and contributed to worse prognosis in DCM patients.
This study indicated that CXCL13 (show CXCL13 ELISA Kits) rather than IL-31 may have clinical values of diagnosis and prognosis in hepatocellular carcinoma.
The first demonstration of the involvement of the IL-31/IL-31R axis in cancer came from studies in patients with mycosis fungoides/Sezary syndrome, the most frequent, cutaneous T cell lymphoma. Tumor cells were shown to produce IL-31, whose serum levels correlated with pruritus intensity.
IL31 and its receptor, IL31RA (show IL31RA ELISA Kits), are highly expressed in various human and mouse cancer cell lines, as well as in tumor specimens from cancer patients. MC38 murine colon carcinoma cells depleted of IL31 exhibit an increase in invasive and migratory properties in vitro.
this study shows that IL-31 may be involved in the pathogenesis of asthma and rhinitis; dust mite and mugwort allergy could increase it significantly
While serum TSLP (show TSLP ELISA Kits) levels were unaffected by concomitant allergies and atopic comorbidities, serum levels of IL-31, IL-33 (show IL33 ELISA Kits) and sST2 (show SSTR2 ELISA Kits) were affected to a small extent. We found a positive correlation between TSLP (show TSLP ELISA Kits), IL-31 and IL-33 (show IL33 ELISA Kits), and an inverse relationship between IL-33 (show IL33 ELISA Kits) and sST2 (show SSTR2 ELISA Kits)
Suggest that IL-31 gene may play a role in the development of systemic lupus erythematosus.
High IL31 expression is associated with Endometrial Cancer.
Oncostatin M (show OSM ELISA Kits) and interleukin-31: Cytokines, receptors, signal transduction and physiology.
IL-31 upregulates IL-31RA (show IL31RA ELISA Kits) expression in DRG neuron cell bodies, and cutaneous-injected IL-31-induced itching is enhanced by DRG IL-31RA (show IL31RA ELISA Kits) expression in mice
our results suggest a functional cooperation between NFAT1 (show NFAT1 ELISA Kits) and JunB (show JUNB ELISA Kits) in mediating IL-31 gene expression in CD4 (show CD4 ELISA Kits)(+) T cells
Data not only illustrate various functions that cysteines perform during IL-31 biosynthesis and secretion, but also highlight their potential roles in cytokine effector functions.
IL-31 may be involved in promoting the dermatitis and epithelial responses that characterize allergic and non-allergic diseases
IL-31 interaction with IL-31 receptor (IL-31R) is identified in an acute model of T helper cell type 2 inflammation in the lung.
these data provide the first evidence of a function for IL-31-IL-31R interactions in limiting the magnitude of type 2 inflammatory responses within the intestine.
IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma (Dillon et al., 2004
, interleukin 31