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The protein encoded by IL31RA belongs to the type I cytokine receptor family. Additionally we are shipping Interleukin 31 Receptor A Antibodies (53) and Interleukin 31 Receptor A Kits (10) and many more products for this protein.
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The first demonstration of the involvement of the IL-31/IL-31R axis in cancer came from studies in patients with mycosis fungoides/Sezary syndrome, the most frequent, cutaneous T cell lymphoma. Tumor cells were shown to produce IL-31, whose serum levels correlated with pruritus intensity.
The interleukin IL-31/IL-31receptor axis contributes to tumor growth in human follicular lymphoma.
detected in keratinocytes and nerve fibers in the dermis of atopic dermatitis and in the neurons of normal dorsal root ganglia
IL31RA is a functional receptor expressed by a small subpopulation of IL-31RA(+)/TRPV1(+)/TRPA1(+) neurons and is a critical neuroimmune link between TH2 cells and sensory nerves for the generation of T cell-mediated itch.
IL-31 and IL-31RA are upregulated in patients with allergic rhinitis, and induce MUC5AC gene expression in human airway epithelial cells.
IFN-gamma-induced IL-31RA upregulation in dermal microvascular endothelium is processed via JNK and PI3 kinase activation
The identification of OSMR and IL31RA gene pathology provides an explanation of the high prevalence of primary cutaneous amyloidosis in Taiwan as well as new insight into disease pathophysiology.
A novel type I cytokine receptor is expressed on monocytes, signals proliferation, and activates STAT-3 and STAT-5.
GPL is a novel cytokine receptor related to GP130 and leukemia inhibitory factor receptor
the molecular mechanisms underlying GPL-mediated signal transduction
IL-31 receptor alpha expression in epidermal keratinocytes is modulated by cell differentiation and interferon gamma
). Binding of IL-31 to its receptor activates Jak/STAT, PI3K/AKT and MAPK pathways.[review]
IL-31 upregulates IL-31RA expression in DRG neuron cell bodies, and cutaneous-injected IL-31-induced itching is enhanced by DRG IL-31RA expression in mice
Anti-IL-31 receptor antibody is shown to be a potential therapeutic option for treating itch and dermatitis in mice
Gp130(757F/F) mice rapidly develop distal stomach tumors, with loss of SHP2/Erk/AP-1 transcriptional regulation exemplified by decreased TFF1 expression and increased STAT1/3 regulated genes such as Reg I.
IL-31 receptor alpha signaling is a novel negative regulatory pathway that specifically limits T helper cell type 2 inflammation.
these data provide the first evidence of a function for IL-31-IL-31R interactions in limiting the magnitude of type 2 inflammatory responses within the intestine.
The protein encoded by this gene belongs to the type I cytokine receptor family. This receptor, with homology to gp130, is expressed on monocytes, and is involved in IL-31 signaling via activation of STAT-3 and STAT-5. It functions either as a monomer, or as part of a receptor complex with oncostatin M receptor (OSMR). Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
interleukin 31 receptor A
, gp130-like monocyte receptor
, IL-31 receptor subunit alpha
, IL-31R subunit alpha
, class I cytokine receptor
, cytokine receptor-like 3
, interleukin-31 receptor subunit alpha
, soluble type I cytokine receptor CRL3
, cytokine receptor NR10
, gp130-like receptor
, interleukin 31RA
, novel cytokine receptor 10