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IL4I1 encodes a protein with limited similarity to L-amino acid oxidase which contains the conserved amino acids thought to be involved in catalysis and binding of flavin adenine dinucleotide (FAD) cofactor. Additionally we are shipping Interleukin 4 Induced 1 Antibodies (41) and Interleukin 4 Induced 1 Kits (10) and many more products for this protein.
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IL4I1 promotes central nervous system remyelination and axonal integrity.
our findings indicate that IL4I1 promotes an enhanced M2 functional phenotype.
inhibits CD8 (show CD8A Proteins)+ antitumor T-cell response in vivo
The H46 locus on chromosome 7 was found to encode the interleukin 4 (show IL4 Proteins)-induced IL4i1 gene.
Data showed proteome changes in alveolar epithelial cells type II exposed to an infection with A. fumigatus with IL4I1 showing the most prominent increase in abundance both, in terms of relative abundance as well as activity. Also, in the infected lungs, there was levels of IL4I1 metabolic products.
reviewed SNPs of the IL4I1 isoform 1, which is expressed in lymphoid tissue; the N92D SNP leads to a hyperactive enzyme, while the R102G mutation is hypomorphic; show that IL4I1 activity is not only directed against phenylalanine, as initially described, but also at a lower level against arginine
The immunosuppressive enzyme IL4I1 expressed differentially in human induced Aiolos (show IKZF3 Proteins)+, but not natural Helios (show ZNFN1A2 Proteins)+, FOXP3 (show FOXP3 Proteins)+ Treg cells.
IL4I1 upregulation in human Th17 cells limits their TCR-mediated expansion not only by blocking the molecular pathway involved in the activation of the IL-2 promoter, but also by maintaining high levels of Tob1, which impairs entry into the cell cycle.
IL4I1 plays a distinct role compared to other antibacterial enzymes produced by mononuclear phagocytes.
participates in the downregulation of Th1 (show TH1L Proteins) inflammation
hIL4I1 inhibited the proliferation of CD3 (show CD3 Proteins)-stimulated T lymphocytes with a similar effect on CD4 (show CD4 Proteins)(+) and CD8 (show CD8A Proteins)(+) T cells. In contrast, memory T cells were more strongly affected by hIL4I1 and its catabolite H(2)O(2) than naive T cells
strong IL4I1 expression is associated with B-cell lymphomas.
This gene encodes a protein with limited similarity to L-amino acid oxidase which contains the conserved amino acids thought to be involved in catalysis and binding of flavin adenine dinucleotide (FAD) cofactor. The expression of this gene can be induced by interleukin 4 in B cells, however, expression of transcripts containing the first two exons of the upstream gene is found in other cell types. Multiple transcript variants encoding different isoforms have been found for this gene.
interleukin 4 induced 1
, IL4-induced protein 1
, L-amino acid oxidase
, L-amino-acid oxidase
, interleukin-4-induced protein 1
, interleukin-four induced gene 1
, interleukin-four induced gene-1 protein
, interleukin-four induced protein-1
, protein Fig-1
, Fig-1 protein
, interleukin four induced 1