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Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Additionally we are shipping Internexin Neuronal Intermediate Filament Protein, alpha Antibodies (150) and Internexin Neuronal Intermediate Filament Protein, alpha Proteins (5) and many more products for this protein.
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reduced/loss of expression of alpha-internexin was closely related to tumors with aggressiveness and patient's adverse prognosis
The proteins UCH-L1 and alpha-internexin could be independent prognostic biomarkers of pancreatic neuroendocrine tumors.
Data suggest GRINL1A (GCOM1)-NMDA receptor-internexin-alpha (INA) interaction pathway may be relevant to neuroprotection.
It is a neuronal marker, and has been indicated as an immunohistochemical surrogate of chromosome 1p/19q co-deletion in oligodendroglial tumors.
Gonadotropinomas, null cell pituitary adenomas, and thyrotropinomas exhibit high levels of intracellular INA protein indicating neuronal transdifferentiation.
It is a supportive diagnostic marker for oligodendroglial tumors with the 1p/19q co-deletion.
alpha-Internexin was expressed in 53% of 350 pancreatic neuroendocrine tumors. Reduced expression of alpha-internexin was significantly associated with advanced stage metastases, recurrence and shorter overall survival.
High INA expression is associated with grade II gliomas.
INA may provide additional biologic information relevant to delineation of both pancreatic neuroendocrine neoplasms (NEN) tumor phenotypes and clinical behavior.
the importance of alpha-internexin and NF-L in regulating the conformations of NF-M and NF-H
alpha-internexin expression in neuroblastoma
The discovery of alpha-internexin in the cytoplasmic inclusions implicates novel mechanisms of pathogenesis in inclusion diseeae and other neurological diseases with pathological accumulations of IFs.
Abnormal neuronal intermediate filament inclusions of alpha-internexin have been identified as the pathological hallmark of neuronal intermediate filament inclusion disease
Expression of the 2 markers, alpha-internexin and peripherin, in a small round cell tumor strongly favors the diagnosis of neuroblastoma.
Alpha-Internexin (INA) expression appears to be a simple, reliable prognostic marker and a surrogate marker of 1p19q codeletion.
This protein has been found differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia.
Neurofilament light chain (NFL) and neuronal intermediate filament protein alpha-internexin accumulate in axon swellings in the spinal white matter in superoxide dismutase (SOD)-1 mouse.
Therefore, the cre transgene driven by mouse alpha-internexin promoter, described here, provides a useful animal model to specifically manipulate genes in the developing nervous system.
Alpha-internexin coassembles with all 3 neurofilament proteins into a single network of filaments. All of them are functionally interdependent. It is a fourth subunit of neurofilaments in the adult CNS.
abnormal accumulation of neuronal IFs in the swelling axons and abnormal translocation of alpha-internexin in the nuclei of the spinal motor neurons from dystonia musculorum mice may not directly cause cell death of the spinal motor neurons
RE1 silencing transcription factor (REST) plays a contributory role in the neuron-specific expression of the alpha-internexin, NF-H and NF-M genes
Study provided a detailed characterization of inaa in the zebrafish; reports evidence that supports zebrafish inaa as a homologous protein of mammalian alpha-internexin and that, physiologically, inaa exhibited the properties of mammalian alpha-internexin. The distribution of inaa was dynamic and widespread through the zebrafish retinal development. Inaa was distinctively expressed in the cone photoreceptors of zebrafish.
inab is necessary for proper axon morphology of a specific motoneuron subtype
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene is a member of the intermediate filament family and is involved in the morphogenesis of neurons.
66 kDa neurofilament protein
, neurofilament 5 (66kD)
, neurofilament-66, tax-binding protein
, internexin, alpha
, internexin neuronal intermediate filament protein, alpha
, internexin neuronal intermediate filament protein, alpha b