Iron-Sulfur Cluster Scaffold Homolog (E. Coli) Proteins (ISCU)

Iron-sulfur (Fe-S) clusters are necessary for several mitochondrial enzymes and other subcellular compartment proteins. Additionally we are shipping ISCU Antibodies (64) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ISCU 23479 Q9H1K1
Rat ISCU ISCU 288740  
ISCU 66383 Q9D7P6
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Top ISCU Proteins at antibodies-online.com

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,370.21
Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,370.21
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days
$814.00
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Escherichia coli (E. coli) Human His tag 50 μg Log in to see 15 to 19 Days
$953.85
Details
Yeast Shigella flexneri His tag   1 mg Log in to see 60 to 71 Days
$2,262.33
Details
Human Un-conjugated   50 μg Log in to see 6 Days
$1,876.29
Details

ISCU Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for Iron-Sulfur Cluster Scaffold Homolog (E. Coli) (ISCU) Interaction Partners

Human Iron-Sulfur Cluster Scaffold Homolog (E. Coli) (ISCU) interaction partners

  1. identifies an important regulatory role for zinc-bound ISCU in modulation of the human Fe-S assembly system in vitro and reports no 'FXN bypass' effect on mutations at position Met140 in human ISCU

  2. we report the first heterozygous dominant mutation in ISCU; notably, this alteration resulted in a similar phenotype as the recessive ISCU disease previously described.

  3. When ISCU was replaced by the fully structured variant ISCU(M108I), the addition of rdFDX2 to the [NIA-ISCU(M108I)-FXN]2 complex led to the release of FXN. Thus, the displacement of FXN by rdFDX2 explains the failure of FXN to stimulate Fe-S cluster assembly on ISCU(M108I).

  4. We have shown that ASO treatment diminished aberrant splicing and increased ISCU protein levels in both patient fibroblasts and patient myotubes in a concentration dependent fashion. Upon ASO treatment, levels of SDHB in patient myotubular cell lines increased to levels observed in control myotubular cell lines

  5. The NFS1/ISD11 complex further interacts with scaffold protein ISCU and regulator protein frataxin, thereby forming a quaternary complex for Fe-S cluster formation.

  6. Molecular dynamics flexible fitting of protein structures docked into the EM map of the model revealed a [FXN(42-210)]24.[NFS1]24.[ISD11]24.[ISCU]24 complex, consistent with the measured 1:1:1:1 stoichiometry of its four components.

  7. ISCU expression was decreased in the majority of human liver cancer tissues, and its reduced expression was significantly associated with p53 mutation.

  8. Thus, driven by acquired (hypoxia) or genetic causes, the miR-210-ISCU1/2 regulatory axis is a pathogenic lynchpin causing iron-sulfur deficiency and pulmonary hypertension.

  9. The core Fe-S biosynthetic enzymatic complex generated [2Fe-2S] cluster intermediates that converted to stable [2Fe-2S] clusters bound to uncomplexed ISCU2.

  10. IscU is a new substrate of MK2 both in Drosophila cells and in human cells

  11. Fe-S assembly protein (ISCU2) and frataxin convert substrates l-cysteine, ferrous iron, and electrons into Fe-S clusters.

  12. the G50E iron-sulfur cluster scaffold protein (ISCU) mutation has a role in mitochondrial myopathy

  13. NFS1 binds preferentially to the D-state of ISCU while mtHSP70 binds preferentially to the D-state of ISCU and HSC20 binds preferentially to the S-state of ISCU.

  14. mTORC1 associates with ISCU and phosphorylates ISCU at serine 14. This phosphorylation stabilized ISCU protein.

  15. MicroRNA-210 correlates negatively with its gene target ISCU at the protein and mRNA level. MicroRNA-210 correlated with positive outcome variables

  16. ISCU protein deficiency in patients results from muscle-specific mis-splicing and oxidative stress.

  17. this study unveiled a signaling axis of HIF-1alpha/miRNA-210/iron-sulfur cluster scaffold protein in a subset of head and neck paragangliomas that could have an impact on SDHB protein stability by a mechanism independent of succinate dehydrogenase mutations

  18. Photoreactive heterotrifunctional chemical cross-linking confirmed the interaction between frataxin and ISCU in the presence of iron and validated that transient interactions can be covalently trapped with this method.

  19. The defective splicing caused by the ISCU intron mutation in patients with myopathy with lactic acidosis is repressed by PTBP1 but can be derepressed by IGF2BP1.

  20. iron-sulfur cluster scaffold homologue down-regulation by miR-210 perturbing trophoblast iron metabolism is associated with defective placentation

Mouse (Murine) Iron-Sulfur Cluster Scaffold Homolog (E. Coli) (ISCU) interaction partners

  1. ISCU expression was decreased in the majority of human liver cancer tissues, and its reduced expression was significantly associated with p53 mutation.

  2. IscU is a marginally stable protein at low ionic strength to the point that undergoes cold denaturation at around -8 degrees C with a corresponding dramatic decrease of enthalpy, which is consistent with the fluxional nature of the protein.

  3. mTORC1 associates with ISCU and phosphorylates ISCU at serine 14. This phosphorylation stabilized ISCU protein.

  4. Data show that complete loss of ISCU results in early embryonic death and confirm a fundamental role for ISCU in mammals.

  5. While IFN-gamma alone induced Nfs1 protein instability, LPS triggered a delayed decline of Nfs1, rather involving transcriptional events or mRNA instability.

  6. Results identify the iron-sulfur cluster assembly proteins (ISCU1/2) as direct targets for repression by the hypoxia-induced microRNA-210.

ISCU Protein Profile

Protein Summary

Iron-sulfur (Fe-S) clusters are necessary for several mitochondrial enzymes and other subcellular compartment proteins. They contain sulfur and iron, and are created via several steps that include cysteine desulfurases, iron donors, chaperones, and scaffold proteins. This gene encodes the two isomeric forms, ISCU1 and ISCU2, of the Fe-S cluster scaffold protein. Mutations in this gene have been found in patients with myopathy with severe exercise intolerance and myoglobinuria.

Gene names and symbols associated with ISCU

  • iron-sulfur cluster assembly enzyme ISCU, mitochondrial (LOC409130)
  • iron-sulfur cluster assembly enzyme (ISCU)
  • iron-sulfur cluster assembly enzyme a (iscua)
  • iron-sulfur cluster assembly enzyme (Iscu)
  • 2310020H20Rik protein
  • AA407971 protein
  • HML protein
  • hnifU protein
  • ISU2 protein
  • Nifu protein
  • Nifun protein
  • RGD1309562 protein
  • si:ch211-191d15.3 protein
  • zC191D15.3 protein

Protein level used designations for ISCU

iron-sulfur cluster assembly enzyme ISCU, mitochondrial , iron-sulfur cluster scaffold homolog (E. coli) , iron-sulfur cluster assembly enzyme , IscU iron-sulfur cluster scaffold homolog (E. coli) , NifU-like N-terminal domain containing , zC191D15.3 (novel protein with leucine-rich repeat domains) , IscU iron-sulfur cluster scaffold homolog , iron-sulfur cluster scaffold homolog , nifU-like N-terminal domain-containing protein , nifU-like protein , ISCU2

GENE ID SPECIES
409130 Apis mellifera
477527 Canis lupus familiaris
514789 Bos taurus
497179 Danio rerio
23479 Homo sapiens
288740 Rattus norvegicus
66383 Mus musculus
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