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ICA1 encodes a protein with an arfaptin homology domain that is found both in the cytosol and as membrane-bound form on the Golgi complex and immature secretory granules.
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ICA69 deficiency promoted formalin-induced long-lasting pain hypersensitivity.
direct link between compromised thymic ICA69 expression and autoimmunity against multiple ICA69-expressing organs, and identify a potential novel mechanism for the development of multi-organ autoimmune diseases.
C-terminal domain of ICA69 interacts with PICK1 (show PICK1 Proteins) and acts on trafficking of PICK1 (show PICK1 Proteins)-PKCalpha (show PKCa Proteins) complex and cerebellar plasticity.
PICK1 (show PICK1 Proteins) and ICA69 are key regulators of the formation and maturation of insulin (show INS Proteins) granules.
polymorphisms within the NOD Ica1 core promoter may determine AIRE (show AIRE Proteins)-mediated down-regulation of ICA69 expression in medullary thymic epithelial cells.
ICA69(null) nonobese diabetic mice develop diabetes, but resist disease acceleration by cyclophosphamide
Novel association was found between intraocular pressure and a common variant at 7p21 near to GLCCI1 (show GLCCI1 Proteins) and ICA1.
ICA69 as a novel Rab2 (show RAB2A Proteins) effector and its role in regulating the early transport of insulin (show INS Proteins) secretory granule proteins
This gene encodes a protein with an arfaptin homology domain that is found both in the cytosol and as membrane-bound form on the Golgi complex and immature secretory granules. This protein is believed to be an autoantigen in insulin-dependent diabetes mellitus and primary Sjogren's syndrome. Several transcript variants encoding two different isoforms have been found for this gene.
islet cell autoantigen 1, 69kDa
, Islet cell autoantigen 1
, islet cell autoantigen 1-like
, 69 kDa islet cell autoantigen
, islet cell autoantigen 1, 69 kDa
, islet cell autoantigen p69
, diabetes mellitus type I autoantigen
, islet cell autoantigen 1
, islet cell autoantigen 1 isoform