Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial Proteins (IDH2)

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. Additionally we are shipping IDH2 Antibodies (118) and IDH2 Kits (16) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
IDH2 3418 P48735
IDH2 269951 P54071
IDH2 361596 P56574
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Top IDH2 Proteins at antibodies-online.com

Showing 10 out of 20 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
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Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$338.33
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Insect cells (Sf9) Human DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$504.90
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$814.00
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Yeast Arabidopsis thaliana His tag   1 mg Log in to see 60 to 71 Days
$2,927.83
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Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,147.83
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Yeast Cynomolgus His tag   1 mg Log in to see 60 to 71 Days
$3,147.83
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Yeast Wild boar His tag   1 mg Log in to see 60 to 71 Days
$3,147.83
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Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 18 Days
$672.00
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IDH2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, , ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) Interaction Partners

Arabidopsis thaliana Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) interaction partners

  1. Leaf IDH activity reduced by 43% in mutant

Human Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) interaction partners

  1. Identification of driver and subclonal mutations in ASXL1 (show ASXL1 Proteins) and IDH1 (show IDH1 Proteins)/IDH2 genes in an Argentine series of patients with myelofibrosis.

  2. an overview of the biological and clinical implications of IDH1 (show IDH1 Proteins) and IDH2 mutations in acute myeloid leukemia (show BCL11A Proteins) (review).

  3. genetic association studies in population in Czech Republic: Data suggest that mutations in IDH1 (show IDH1 Proteins) and IDH2 are associated with AML (show RUNX1 Proteins) (acute myeloid leukemia (show BCL11A Proteins)); IDH1 (show IDH1 Proteins)/2-based monitoring of MRD (minimal residual disease) appears to have prognostic value for residual disease in AML (show RUNX1 Proteins) patients.

  4. There was significant prognostic difference among the 4 glioma subtypes. Combined IDH (show IDH1 Proteins) and TERT (show TERT Proteins) gene mutation analysis may be useful for prognostic subgrouping. Notably, IDH1 (show IDH1 Proteins) wild-type cases can be further subdivided into TERT (show TERT Proteins)(+ ) or (-) subgroups with significant prognostic difference.

  5. Generation of 2-hydroxyglutarate by mutated IDH1 (show IDH1 Proteins)/2 leads to the activation of mTOR (show FRAP1 Proteins) by inhibiting KDM4A (show KDM4A Proteins).

  6. Enasidenib reduces 2-hydroxyglutarate levels in patients with relapsed or refractory (R/R) acute myeloid leukemia (show BCL11A Proteins) harboring either IDH2-R140 or IDH2-R172 mutations

  7. IDH2 mutation is associated with glioma progression.

  8. No correlation between IDH1 (show IDH1 Proteins)/2 mutation status and sensitivity for NAMPT (show NAMPT Proteins) inhibitors was observed. Strikingly, higher methylation of the NAPRT promoter was observed in high-grade versus low-grade chondrosarcomas. In conclusion, this study identified NAMPT (show NAMPT Proteins) as a potential target for treatment of chondrosarcoma

  9. This study furthers implementation of clinical genomics in MDS (show PAFAH1B1 Proteins) and identifies TP53 (show TP53 Proteins) and IDH2 as targets for pre- or post-transplant therapy

  10. Results highlight that non-canonical IDH mutations are relatively common in grade II and III gliomas: it is therefore important to analyze exon 4 of both IDH1 and IDH2 in these tumors. They also demonstrate that all IDH mutations, including the non-canonical ones are clonally distributed, a finding consistent with their driver role in gliomagenesis.

Mouse (Murine) Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) interaction partners

  1. our findings highlight the role of IDH2 in skin melanogenesis in association with mitochondrial ROS (show ROS1 Proteins) and suggest unique therapeutic strategies for the prevention of skin pigmentation.

  2. Data (including data from studies using knockout mice) suggest that IDH2 plays role in modulating liver fatty acid metabolism in dietary fructose-induced NAFLD (non-alcoholic fatty liver disease). This study was conducted in female mice; previous studies suggest that women are more prone to develop metabolic syndromes in response to fructose-sweetened beverages.

  3. present study supports the central role of idh2 deficiency in inducing oxidative stress resulting from acrolein-induced disruption of mitochondrial redox status in the lung

  4. IDH2 deficiency leads to increased mitochondrial ROS (show ROS1 Proteins) levels, activation of NF-kappaB (show NFKB1 Proteins) and apoptosis of IEC in DSS (show PMP22 Proteins)-induced colitis.

  5. present study, we provided a role for IDH2 in protection against UVB-induced skin damage and a new connection between IDH2 and DeltaNp63.

  6. The disruption of IDH2 attenuates age-associated hepatic steatosis by the activation of p38 (show CRK Proteins)/cJun (show JUN Proteins) NH2-terminal kinase (JNK (show MAPK8 Proteins)) and p53 (show TP53 Proteins), presumably induced by the elevation of mitochondrial reactive oxygen species (ROS (show ROS1 Proteins)), which in turn resulted in the suppression of hepatic lipogenesis and inflammation via the upregulation of fibroblast growth factor 21 (FGF21 (show FGF21 Proteins)) and the inhibition of NFkappaB signaling pathways.

  7. We propose that D2-HG promotes cardiac dysfunction by impairing alpha-ketoglutarate dehydrogenase (show alphaKGDHC Proteins) and induces histone modifications in an ACL (show APOC4 Proteins)-dependent manner.Combining mathematical modeling and in vivo as well as ex vivo studies, we found that increased amounts of the oncometabolite d-2-hydroxyglutarate (D2-HG), produced by IDH2 mutant leukemic cells, cause contractile dysfunction in the heart

  8. Increased obesity resistance and insulin (show INS Proteins) sensitivity in mice lacking the IDH2 gene has been documented.

  9. treatment with Mito-TEMPO, a mitochondrial-specific superoxide scavenger, recovered mitochondrial fission-fusion imbalance and blunted mitochondrial superoxide production, and reduced the IDH2 knockdown-induced decrease in MnSOD (show SOD2 Proteins) expression, eNOS (show NOS3 Proteins) phosphorylation and NO production in endothelial cells

  10. Findings demonstrate that IDH2 contributes to degeneration of the DA neuron in the neurotoxin model of Parkinson's Disease.

Cow (Bovine) Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) interaction partners

  1. The enzyme is highly sensitive to Mg(2 (show MCOLN1 Proteins)+) concentration in the physiological range, pointing to a potential regulatory role of [Mg(2 (show MCOLN1 Proteins)+)] in mitochondrial energy metabolism.

Pig (Porcine) Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) interaction partners

  1. Tyr140 and Lys212 are required for the catalytic activity of porcine NADP-dependent isocitrate dehydrogenase (show IDH3B Proteins)

  2. analysis of the coenzyme binding site in the porcine mitochondrial NADP-dependent isocitrate dehydrogenase (show IDH3B Proteins)

  3. These results suggest that IDPm plays an important protective role in cadmium-induced apoptosis by maintaining cellular redox status and by protection of Grx (show GRX1 Proteins) activity.

IDH2 Protein Profile

Protein Summary

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex.

Gene names and symbols associated with IDH2

  • isocitrate dehydrogenase subunit 2 (IDH2)
  • isocitrate dehydrogenase (NADP(+)) 2, mitochondrial (IDH2)
  • isocitrate dehydrogenase 2 (NADP+), mitochondrial (Idh2)
  • isocitrate dehydrogenase (NADP(+)) 2, mitochondrial (Idh2)
  • isocitrate dehydrogenase 2 (NADP+), mitochondrial S homeolog (idh2.S)
  • isocitrate dehydrogenase 2 (NADP+), mitochondrial (idh2)
  • isocitrate dehydrogenase [NADP], mitochondrial (LOC100441867)
  • D2HGA2 protein
  • E430004F23 protein
  • F6P23.14 protein
  • F6P23_14 protein
  • ICD-M protein
  • IDH protein
  • Idh-2 protein
  • IDH-II protein
  • IDH2 protein
  • IDHM protein
  • IDP protein
  • IDPm protein
  • isocitrate dehydrogenase II protein
  • isocitrate dehydrogenase subunit 2 protein
  • mNADP-IDH protein
  • NAD+ DEPENDENT ISOCITRATE DEHYDROGENASE SUBUNIT 2 protein
  • wu:fb33c06 protein
  • wu:fk31e05 protein
  • wu:fq43b01 protein
  • zgc:55485 protein

Protein level used designations for IDH2

NADP(+)-specific ICDH , isocitrate dehydrogenase [NADP], mitochondrial , oxalosuccinate decarboxylase , ICD-M , IDH , IDP , NADP+-specific isocitrate dehydrogenase , NADPH-specific isocitrate dehydrogenase , isocitrate dehydrogenase 2 (NADP+), mitochondrial , isocitrate dehydrogenase [NADP], mitochondrial-like

GENE ID SPECIES
816218 Arabidopsis thaliana
3418 Homo sapiens
269951 Mus musculus
327669 Bos taurus
361596 Rattus norvegicus
380013 Xenopus laevis
386951 Danio rerio
397603 Sus scrofa
448026 Xenopus (Silurana) tropicalis
453645 Pan troglodytes
479043 Canis lupus familiaris
701480 Macaca mulatta
100441867 Pongo abelii
431056 Gallus gallus
100726681 Cavia porcellus
100340796 Oryctolagus cuniculus
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