Isocitrate Dehydrogenase 3 (NAD+) beta Proteins (IDH3B)

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. Additionally we are shipping Isocitrate Dehydrogenase 3 (NAD+) beta Antibodies (92) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
IDH3B 3420 O43837
Rat IDH3B IDH3B 94173 Q68FX0
Mouse IDH3B IDH3B 170718  
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Top Isocitrate Dehydrogenase 3 (NAD+) beta Proteins at antibodies-online.com

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
$6,749.58
Details
Wheat germ Human GST tag 2 μg 11 to 12 Days
$338.33
Details
Escherichia coli (E. coli) Human GST tag 100 μg 11 Days
$356.40
Details
Yeast Wild boar His tag   1 mg 60 to 71 Days
$2,185.33
Details
Yeast Cynomolgus His tag   1 mg 60 to 71 Days
$2,955.33
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Yeast Orang-Utan His tag   1 mg 60 to 71 Days
$2,955.33
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Yeast Cow His tag   1 mg 60 to 71 Days
$2,959.00
Details

IDH3B Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,

More Proteins for Isocitrate Dehydrogenase 3 (NAD+) beta (IDH3B) Interaction Partners

Human Isocitrate Dehydrogenase 3 (NAD+) beta (IDH3B) interaction partners

  1. Human NAD-dependent isocitrate dehydrogenase (IDH) is a heterotetrameric mitochondrial enzyme with 2alpha:1beta:1gamma subunit ratio subunits shich share 40-52% identity in amino acid sequence.

  2. IDPm activity appears to be modulated through enzymatic glutathionylation and deglutathionylation during oxidative stress

  3. active sites of the human NAD-IDH are shared between alpha and gamma subunits and between alpha and beta subunits

  4. Asp192 is needed for optimal affinity of IDH beta subunit for nicotinamide-adenine dinucleotide (NAD) substrate, but is not critical for catalysis.

  5. Homozygous for loss-of-function mutations in IDH3B is associated with retinitis pigmentosa.

  6. The point mutations of isocitrate dehydrogenase are essentially unique to gliomas.

Isocitrate Dehydrogenase 3 (NAD+) beta (IDH3B) Protein Profile

Protein Summary

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the beta subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Gene names and symbols associated with IDH3B

  • isocitrate dehydrogenase 3 (NAD(+)) beta (IDH3B)
  • isocitrate dehydrogenase 3 (NAD+) beta (Idh3B)
  • isocitrate dehydrogenase 3 (NAD+) beta (Idh3b)
  • isocitrate dehydrogenase 3 (NAD+) beta (idh3b)
  • isocitrate dehydrogenase 3 (NAD+) beta S homeolog (idh3b.S)
  • isocitrate dehydrogenase 3 (NAD(+)) beta (Idh3b)
  • C78231 protein
  • H-IDHB protein
  • IDH1 protein
  • IDH3 protein
  • MGC79028 protein
  • RP46 protein
  • zgc:86647 protein

Protein level used designations for IDH3B

NAD(+)-specific ICDH subunit beta , NAD+-specific ICDH , NAD+-specific isocitrate dehydrogenase b subunit , NAD+-specific isocitrate dehydrogenase beta , isocitrate dehydrogenase [NAD] subunit beta, mitochondrial , isocitrate dehydrogenase, NAD(+)-specific, mitochondrial, beta subunit , isocitric dehydrogenase subunit beta , N14A tumor-related protein , isocitrate dehydrogenase 3 beta , isocitrate dehydrogenase 3, beta subunit , isocitrate dehydrogenase 3 (NAD+) beta , NAD(+)-dependent isocitrate dehydrogenase subunit 3 , NAD(+)-isocitrate dehydrogenase subunit 1 , mitochondrial NAD+isocitrate dehydrogenase 3 beta variant 2 , isocitrate dehydrogenase [NAD] subunit beta, mitochondrial-like

GENE ID SPECIES
3420 Homo sapiens
94173 Rattus norvegicus
170718 Mus musculus
415247 Danio rerio
426573 Gallus gallus
443821 Xenopus laevis
458048 Pan troglodytes
477177 Canis lupus familiaris
613338 Bos taurus
733641 Sus scrofa
100144949 Xenopus (Silurana) tropicalis
100172344 Pongo abelii
100403538 Callithrix jacchus
100717400 Cavia porcellus
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