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Has low protease activity towards poly-ubiquitin chains (in vitro). Additionally we are shipping Josephin Domain Containing 1 Antibodies (14) and many more products for this protein.
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In this study, the authors report that JOSD1 plays an important role in regulating type-I interferon (show IFNA Proteins) (IFN-I)-mediated antiviral activity. JOSD1 physically interacts with SOCS1 (show SOCS1 Proteins), which is an essential negative regulator of many cytokines signaling, and enhances SOCS1 (show SOCS1 Proteins) stability by deubiquitinating K48-linked polyubiquitination of SOCS1 (show SOCS1 Proteins).
The gain of function studies indicated that Josephin domain containing 1 activate NR5A1 (show NR5A1 Proteins) gene expression.
JosD1, a membrane-associated DUB whose activity is regulated by ubiquitination, helps regulate membrane dynamics, cell motility, and endocytosis.
Has low protease activity towards poly-ubiquitin chains (in vitro). May act as a deubiquitinating enzyme.
Josephin domain containing 1
, josephin domain-containing protein 1
, josephin domain-containing 1