Jumping Translocation Breakpoint Proteins (JTB)

Required for normal cytokinesis during mitosis. Additionally we are shipping Jumping Translocation Breakpoint Antibodies (26) and Jumping Translocation Breakpoint Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
JTB 10899 O76095
JTB 23922 O88824
JTB 29439 O88823
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Top Jumping Translocation Breakpoint Proteins at antibodies-online.com

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
Human Cells Human Fc Tag 100 μg Log in to see 14 to 16 Days
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 13 to 16 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
Yeast Brugia malayi His tag   1 mg Log in to see 60 to 71 Days

JTB Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Jumping Translocation Breakpoint (JTB) Interaction Partners

Human Jumping Translocation Breakpoint (JTB) interaction partners

  1. Downregulation of the PAR expression increases the Bax/Bcl-2 ratio and Bax expression, and thus induces the G2-M phase arrest and apoptosis of PC3 cells.

  2. Silencing of the JTB resulted in an increase in the phosphorylation of p65 in HepG2 cells.

  3. The JTB structure has a distant relationship to the midkine/pleiotrophin fold, particularly in the conservation of distinctive disulfide bridge patterns.

  4. Due to its involvement in cell cycle and its overexpression in several human cancers PAR could represent an attractive target for therapeutic intervention.

  5. Among ten hepatocellular carcinoma cases with amplicon 1q21-q22, significant gene expression level of JTB, SHC1, CCT3 and COPA in the tumors than the paired adjacent non-malignant liver tissues.

  6. Overexpression of JTB conferred resistance to apoptosis induced by ultraviolet radiation

Jumping Translocation Breakpoint (JTB) Protein Profile

Protein Summary

Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity).

Gene names and symbols associated with JTB

  • jumping translocation breakpoint (JTB)
  • jumping translocation breakpoint (Jtb)
  • Gm622 protein
  • hJT protein
  • HJTB protein
  • HSPC222 protein
  • JTB protein
  • PAR protein

Protein level used designations for JTB

jumping translocation breakpoint protein , prostate androgen-regulated protein , protein JTB , jumping translocation breakpoint

10899 Homo sapiens
23922 Mus musculus
29439 Rattus norvegicus
457342 Pan troglodytes
513970 Bos taurus
612300 Canis lupus familiaris
770053 Gallus gallus
100145894 Sus scrofa
100357915 Oryctolagus cuniculus
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