K(lysine) Acetyltransferase 6B Proteins (KAT6B)

The protein encoded by KAT6B is a histone acetyltransferase and component of the MOZ/MORF protein complex.

list all proteins Gene Name GeneID UniProt
Human KAT6B KAT6B 23522 Q8WYB5
Mouse KAT6B KAT6B 54169 Q8BRB7
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Top KAT6B Proteins at antibodies-online.com

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Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days

More Proteins for K(lysine) Acetyltransferase 6B (KAT6B) Interaction Partners

Human K(lysine) Acetyltransferase 6B (KAT6B) interaction partners

  1. KAT6B mutation is associated with Craniosynostosis.

  2. chronic inflammation compromises unfolded protein response function through MORF-mediated-PERK transcription.

  3. With ptosis, hypotonia, and developmental delay as the main diagnostic features of our patient, the effect of histone acetyltransferase-encoding KAT6B gene haploinsufficiency was suspected to have a significant role in determining the phenotype.

  4. Study identified the double plant homeodomain finger (DPF) of the lysine acetyltransferase MORF as a reader of global histone H3K14 acylation.

  5. Our findings support that phenotypes associated with typical KAT6B disease-causing variants should be referred to as 'KAT6B spectrum disorders' or 'KAT6B related disorders', rather than their current SBBYSS and GTPTS classification

  6. Studies show that misregulation of MOZ/MORF results in tumorigenesis and developmental disorders. Results also provide evidence that these 2 proteins play important role in regulating cell proliferation and stem cell maintenance. [review]

  7. KAT6B sequence variants are being reported in the Say-Barber-Biesecker type of blepharophimosis mental retardation syndromes (SBBS) and in the more severe genitopatellar syndrome.

  8. This study shown MYST4 to be the risk factor for attention deficit/hyperactivity disorder.

  9. Homozygous deletions of KAT6B and the loss of its mRNA occur in SCLC cell lines and primary tumors. KAT6B loss enhances cancer growth. Restoration induces tumor suppressor-like features involving a new type of histone H3 Lys23 acetyltransferase activity.

  10. The relationship between MYO1C (show MYO1C Proteins) and KAT6B suggests that the two are interacting in chromatin remodelling for gene expression in human masseter muscle. This is the nuclear myosin1 (NM1 (show MYO1C Proteins)) function of MYO1C (show MYO1C Proteins).

Cow (Bovine) K(lysine) Acetyltransferase 6B (KAT6B) interaction partners

  1. MYST4 may contribute to important and specific acetylation events occurring during gametes and embryo development

Mouse (Murine) K(lysine) Acetyltransferase 6B (KAT6B) interaction partners

  1. Silence of lysine acetyltransferase 6B (KAT6B) suppressed lipopolysaccharide(LPS (show TLR4 Proteins))-induced IL-6 (show IL6 Proteins) production in peritoneal macrophages.

  2. Data indicate that Myst4, Jmjd2b, Aof1 (show KDM1B Proteins) genes are regulated by H3K9me under hyperinsulinemia/hyperglycemia.

  3. Data show that H3 acetylation by Myst4 is important for neural, craniofacial, and skeletal morphogenesis, mainly through its ability to specifically regulating the MAPK (show MAPK1 Proteins) signaling pathway.

  4. Deregulation of polyamine biosynthesis alters intrinsic histone acetyltransferase and deacetylase activities in murine skin and tumors.

  5. MORF4 has a role in cellular aging, and MRG15 (show MORF4L1 Proteins) associates with both histone deacetylases and histone acetyl transferase (show HAT1 Proteins) complexes [review]

KAT6B Protein Profile

Protein Summary

The protein encoded by this gene is a histone acetyltransferase and component of the MOZ/MORF protein complex. In addition to its acetyltransferase activity, the encoded protein has transcriptional activation activity in its N-terminal end and transcriptional repression activity in its C-terminal end. This protein is necessary for RUNX2-dependent transcriptional activation and could be involved in brain development. Mutations have been found in patients with genitopatellar syndrome. A translocation of this gene and the CREBBP gene results in acute myeloid leukemias. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with KAT6B

  • K(lysine) acetyltransferase 6B (kat6b)
  • lysine acetyltransferase 6B (KAT6B)
  • K(lysine) acetyltransferase 6B (Kat6b)
  • AI507552 protein
  • B130044K16Rik protein
  • GTPTS protein
  • id:ibd5103 protein
  • mKIAA0383 protein
  • Morf protein
  • MOZ2 protein
  • MYST-4 protein
  • Myst4 protein
  • qkf protein
  • querkopf protein
  • si:dkey-24f15.3 protein
  • ZC2HC6B protein

Protein level used designations for KAT6B

histone acetyltransferase MYST4 , MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4 , MOZ-related factor , MYST histone acetyltransferase (monocytic leukemia) 4 , MYST-4 , histone acetyltransferase KAT6B , histone acetyltransferase MORF , histone acetyltransferase MOZ2 , monocytic leukemia zinc finger protein-related factor , MYST histone acetyltransferase monocytic leukemia 4 , histone acetyltransferase querkopf , monocytic leukemia , protein querkopf

568932 Danio rerio
423734 Gallus gallus
23522 Homo sapiens
479254 Canis lupus familiaris
535403 Bos taurus
54169 Mus musculus
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