anti-KIAA0226 (KIAA0226) Antibodies

Negatively regulates endocytic trafficking. Additionally we are shipping KIAA0226 Proteins (2) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
KIAA0226 9711 Q92622
KIAA0226 100502698 Q80U62
KIAA0226    
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Top anti-KIAA0226 Antibodies at antibodies-online.com

Showing 10 out of 60 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-KIAA0226 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:1562500<br><b>Positive Control: </b>Human Placenta WB Suggested Anti-KIAA0226 <br /> Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:1562500 <br /> Positive Control: Human Placenta 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB Western blot analysis of BARON antibody (N-term) (ABIN388583) in MCF-7 cell line lysates (35 µg/lane). BARON (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human lymph with BARON Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$335.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated IP, WB Immunoprecipitation: KIAA0226 Antibody [NBP1-30461] - Whole cell lysate (5, 15 and 50 mcg for WB; 1 mg for IP, 20% of IP loaded) from HeLa cells. NBP1-30461 used for WB at 0.4 mcg/ml (A) and 1 mcg/ml (B) and used for IP at 3 mcg/mg lysate. Rubicon was also immunoprecipitated by another rabbit anti-Rubicon antibody, which recognizes an upstream epitope. Western Blot: Rubicon Antibody  - Detection of Human Rubicon by Western Blot. Samples: Whole cell lysate (50 ug) from HeLa and 293T cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-Rubicon antibody NBP1-30461 used for WB at 0.4 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds. 100 μL Log in to see 7 to 9 Days
$556.31
Details
Human Rabbit Un-conjugated ELISA, IF, IHC (p), WB   0.1 mg Log in to see 2 to 3 Days
$350.00
Details
Human Rabbit HRP ICC, IF, WB Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-Rubicon Polyclonal Antibody . Tissue: Colon carcinoma cell line (RKO). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Rabbit Anti-Rubicon Polyclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Rabbit ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60 min at RT, 5 min at RT. Localization: Late Endosome, Lysosome, Early Endosome . Magnification: 60X. (A) DAPI nuclear stain. (B) Phalloidin Texas Red F-Actin stain. (C) Rubicon Antibody. (D) Composite. Western blot analysis of Human HeLa cell lysates showing detection of ~108 kDa Rubicon protein using Rabbit Anti-Rubicon Polyclonal Antibody . Lane 1: Molecular Weight Ladder (MW). Lane 2: HeLa cell lysates. Load: 15 µg. Block: 5% Skim Milk in 1X TBST. Primary Antibody: Rabbit Anti-Rubicon Polyclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Goat Anti-Rabbit IgG: HRP at 1:1000 for 60 min at RT. Color Development: ECL solution for 6 min in RT. Predicted/Observed Size: ~108 kDa. 100 μg Log in to see 2 to 3 Days
$487.03
Details
Human Rabbit FITC ICC, IF, WB Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-Rubicon Polyclonal Antibody . Tissue: Colon carcinoma cell line (RKO). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Rabbit Anti-Rubicon Polyclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Rabbit ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60 min at RT, 5 min at RT. Localization: Late Endosome, Lysosome, Early Endosome . Magnification: 60X. (A) DAPI nuclear stain. (B) Phalloidin Texas Red F-Actin stain. (C) Rubicon Antibody. (D) Composite. Western blot analysis of Human HeLa cell lysates showing detection of ~108 kDa Rubicon protein using Rabbit Anti-Rubicon Polyclonal Antibody . Lane 1: Molecular Weight Ladder (MW). Lane 2: HeLa cell lysates. Load: 15 µg. Block: 5% Skim Milk in 1X TBST. Primary Antibody: Rabbit Anti-Rubicon Polyclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Goat Anti-Rabbit IgG: HRP at 1:1000 for 60 min at RT. Color Development: ECL solution for 6 min in RT. Predicted/Observed Size: ~108 kDa. 100 μg Log in to see 2 to 3 Days
$492.09
Details
Human Rabbit Alkaline Phosphatase (AP) ICC, IF, WB Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-Rubicon Polyclonal Antibody . Tissue: Colon carcinoma cell line (RKO). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Rabbit Anti-Rubicon Polyclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Rabbit ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60 min at RT, 5 min at RT. Localization: Late Endosome, Lysosome, Early Endosome . Magnification: 60X. (A) DAPI nuclear stain. (B) Phalloidin Texas Red F-Actin stain. (C) Rubicon Antibody. (D) Composite. Western blot analysis of Human HeLa cell lysates showing detection of ~108 kDa Rubicon protein using Rabbit Anti-Rubicon Polyclonal Antibody . Lane 1: Molecular Weight Ladder (MW). Lane 2: HeLa cell lysates. Load: 15 µg. Block: 5% Skim Milk in 1X TBST. Primary Antibody: Rabbit Anti-Rubicon Polyclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Goat Anti-Rabbit IgG: HRP at 1:1000 for 60 min at RT. Color Development: ECL solution for 6 min in RT. Predicted/Observed Size: ~108 kDa. 100 μg Log in to see 2 to 3 Days
$494.62
Details
Human Rabbit Biotin ICC, IF, WB Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-Rubicon Polyclonal Antibody . Tissue: Colon carcinoma cell line (RKO). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Rabbit Anti-Rubicon Polyclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Rabbit ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60 min at RT, 5 min at RT. Localization: Late Endosome, Lysosome, Early Endosome . Magnification: 60X. (A) DAPI nuclear stain. (B) Phalloidin Texas Red F-Actin stain. (C) Rubicon Antibody. (D) Composite. Western blot analysis of Human HeLa cell lysates showing detection of ~108 kDa Rubicon protein using Rabbit Anti-Rubicon Polyclonal Antibody . Lane 1: Molecular Weight Ladder (MW). Lane 2: HeLa cell lysates. Load: 15 µg. Block: 5% Skim Milk in 1X TBST. Primary Antibody: Rabbit Anti-Rubicon Polyclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Goat Anti-Rabbit IgG: HRP at 1:1000 for 60 min at RT. Color Development: ECL solution for 6 min in RT. Predicted/Observed Size: ~108 kDa. 100 μg Log in to see 2 to 3 Days
$497.15
Details
Human Rabbit PE ICC, IF, WB Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-Rubicon Polyclonal Antibody . Tissue: Colon carcinoma cell line (RKO). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Rabbit Anti-Rubicon Polyclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Rabbit ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60 min at RT, 5 min at RT. Localization: Late Endosome, Lysosome, Early Endosome . Magnification: 60X. (A) DAPI nuclear stain. (B) Phalloidin Texas Red F-Actin stain. (C) Rubicon Antibody. (D) Composite. Western blot analysis of Human HeLa cell lysates showing detection of ~108 kDa Rubicon protein using Rabbit Anti-Rubicon Polyclonal Antibody . Lane 1: Molecular Weight Ladder (MW). Lane 2: HeLa cell lysates. Load: 15 µg. Block: 5% Skim Milk in 1X TBST. Primary Antibody: Rabbit Anti-Rubicon Polyclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Goat Anti-Rabbit IgG: HRP at 1:1000 for 60 min at RT. Color Development: ECL solution for 6 min in RT. Predicted/Observed Size: ~108 kDa. 100 μg Log in to see 2 to 3 Days
$498.41
Details

More Antibodies against KIAA0226 Interaction Partners

Human KIAA0226 interaction partners

  1. Rubicon thus functions as an important negative regulator of the innate immune response, enhances viral replication and may play a role in viral immune evasion.

  2. HCV, by differentially inducing the expression of Rubicon and UVRAG (show UVRAG Antibodies), temporally regulated the autophagic flux to enhance its replication.

  3. This study demonistrated that KIAA0226 mutation impairs Rubicon endosomal localization

  4. New DNA sequencing technologies are enabling us to investigate the whole or large targeted proportions of the genome in a rapid, affordable, and comprehensive way. Exome and targeted sequencing rundataxin genes causing ataxia.

  5. Rubicon may thus be pivotal to generating an optimal intracellular immune response against microbial infection.

  6. Rubicon differentially targets signaling complexes, depending on environmental stimuli, and may function to coordinate various immune responses against microbial infection.

  7. Rubicon and PLEKHM1 (show PLEKHM1 Antibodies) specifically and directly interact with Rab7 (show RAB7B Antibodies) via their RH domain; this interaction is critical for their function; show Rubicon but not PLEKHM1 (show PLEKHM1 Antibodies) uniquely regulates membrane trafficking via simultaneously binding both Rab7 (show RAB7B Antibodies) and PI3-kinase (show PIK3CA Antibodies)

  8. a critical role of the Rubicon RUN domain in PI3KC3 and autophagy regulation

  9. Rubicon serves as a previously unknown Rab7 (show RAB7B Antibodies) effector to ensure the proper progression of the endocytic pathway.

  10. we report the identification of a family with three children affected with a new form of recessive ataxia, which we suggest naming 'Salih ataxia', and of a frameshift mutation of KIAA0226 (rundataxin) that segregates with the disease

Mouse (Murine) KIAA0226 interaction partners

  1. Rubicon specifically interacts with the interferon regulatory factor (IRF) association domain (IAD) of IRF3, and this interaction leads to inhibition of the dimerization of IRF3, which negatively regulates interferon-mediated antiviral response.

  2. Rubicon deficiency enhances autophagic flux in the heart and protects mice from lethality and reduction in stroke volume induced by LPS (show TLR4 Antibodies).

  3. Data indicate that Rubicon (Kiaa0226) and NOX2 (gp91phox (show CYBB Antibodies)) are involved in microtubule-associated protein (show SPAG5 Antibodies) LC3 (show MAP1LC3A Antibodies)-associated phagocytosis.

  4. Beclin 1 (show BECN1 Antibodies) and its binding proteins orchestrate the precise function of the class III PI(3 (show PI3 Antibodies))K in regulating autophagy at multiple steps.

  5. Two Beclin 1 (show BECN1 Antibodies) associated proteins, Atg14L and Rubicon, were identified.

KIAA0226 Antigen Profile

Protein Summary

Negatively regulates endocytic trafficking. Impairs the autophagosome maturation process. May inhibit PIK3C3 activity.

Gene names and symbols associated with anti-KIAA0226 (KIAA0226) Antibodies

  • RUN and cysteine rich domain containing beclin 1 interacting protein (RUBCN) antibody
  • KIAA0226 (KIAA0226) antibody
  • RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein (Rubcn) antibody
  • 5330403K09 antibody
  • Kiaa0226 antibody
  • mKIAA0226 antibody
  • Rubicon antibody

Protein level used designations for anti-KIAA0226 (KIAA0226) Antibodies

KIAA0226 , RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein , RUN domain protein as Beclin 1-interacting and cysteine-rich containing , baron , beclin-1 associated RUN domain containing protein , run domain Beclin-1 interacting and cystein-rich containing protein , run domain Beclin-1 interacting and cysteine-rich containing protein , rundataxin

GENE ID SPECIES
424920 Gallus gallus
460971 Pan troglodytes
9711 Homo sapiens
100502698 Mus musculus
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