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KIAA1279 encodes a kinesin family member 1 binding protein that is characterized by two tetratrico peptide repeats. Additionally we are shipping KIAA1279 Antibodies (24) and many more products for this protein.
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Both Kif15 (show KIF15 Proteins) and KBP are required for the alignment of all the chromosomes to the metaphase plate and the assembly of stable kinetochore fibers of the correct length.
Data suggest that KBP functions as a kinesin inhibitor that modulates MT-based cargo motility and depolymerizing activity of a subset of kinesin motors. We propose that misregulation of KBP-controlled kinesin motors may represent the underlying molecular mechanism that contributes to the neuropathological defects observed in Goldberg-Shprintzen syndrome patients.
A report on fetal cases with a homozygous mutation in KBP gene in a consanguineous Pakistani family with isolated polymicrogyria.
KBP-cytoskeleton interactions is involved in neuronal development in Goldberg-Shprintzen syndrome.
KBP is a new binding partner for KIF1Balpha that is a regulator of its transport function and thus represents a new type of kinesin interacting protein.
TDH, responsible for mitochondrial production of acetyl-CoA (show LPCAT1 Proteins) in mouse embryonic stem cells, and the acetyltransferase GCN5L1 (show BLOC1S1 Proteins) cooperate to acetylate Lys501 in KBP, allowing its recognition by and degradation via Fbxo15 (show FBXO15 Proteins), an F-box protein (show FBXO30 Proteins) transcriptionally controlled by the pluripotency core factors and repressed following differentiation.
KIF1-binding protein interacts with KIF3A (show KIF3A Proteins) in haploid male germ cells, promoting spermatid elongation.
KBP expression is up-regulated during neuronal development in mouse cortical neurons.
This gene encodes a kinesin family member 1 binding protein that is characterized by two tetratrico peptide repeats. The encoded protein localizes to the mitochondria and may be involved in regulating transport of the mitochondria. Mutations in this gene are associated with Goldberg-Shprintzen megacolon syndrome.
, KIF1 binding protein
, KIF1-binding protein-like protein
, KIF1-binding protein homolog