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Expression of KIAA1324 is induced by estrogen and the encoded protein has been characterized as a transmembrane protein.
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The STR (show STATH Proteins) in the upstream regulatory region of EIG121 is highly polymorphic, but is not associated with the risk of developing breast or endometrial cancer in the cohorts analysed here
A tumor suppressive role of KIAA1324 via inhibition of GRP78 (show HSPA5 Proteins) oncoprotein activities in gastric cancer
High expression of ERalpha (show ESR1 Proteins) and the estrogen-induced gene EIG121 predicts shorter overall survival in patients with high-grade serous ovarian carcinoma.
Down-regulation of KIAA1324 protein is associated with endometrial cancer
Expression of this gene is induced by estrogen and the encoded protein has been characterized as a transmembrane protein. The encoded protein has been found in to correlate with survival in certain carcinomas (PMID: 21102415) and may be important for cellular response to stress (PMID: 21072319). Alternative splicing results in multiple transcript variants.
UPF0577 protein KIAA1324
, estrogen induced gene 121
, estrogen-induced gene 121 protein