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Severs microtubules in vitro in an ATP-dependent manner. Additionally we are shipping Katanin P60 Subunit A-Like 2 Proteins (4) and many more products for this protein.
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KATNAL2 methylation correlates with severity of cervical intraepithelial neoplasia
results from de novo events and a large parallel case-control study provide strong evidence in favour of CHD8 (show CHD8 Antibodies) and KATNAL2 as genuine autism risk factors
Authors present data suggesting that depending on context, KATNAL2 can partner with the regulatory protein (show TGFB1 Antibodies) KATNB1 (show KATNB1 Antibodies) or act autonomously. Data indicate KATNAL2 may regulate delta- and epsilon-tubulin (show TUBE1 Antibodies) rather than classical alpha-beta-tubulin (show TUBB Antibodies) microtubule polymers, suggesting the katanin family has a greater diversity of function than previously realised.
KATNAL2 isoforms interact with themselves, with each other and with Nubp1 (show NUBP1 Antibodies) and Nubp2 (show NUBP2 Antibodies).
Authors used Xenopus embryos to reveal that Katnal2 (1) is expressed broadly in ciliated and neurogenic tissues throughout embryonic development; (2) is localized to basal bodies, ciliary axonemes, centrioles, and mitotic spindles; and (3) is required for ciliogenesis and brain development.
Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays (By similarity).
katanin p60 ATPase-containing subunit A-like 2
, p60 katanin-like 2