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May play a role in organizing the actin cytoskeleton of the brain cells.. Additionally we are shipping Kelch-Like 2, Mayven (Drosophila) Proteins (7) and and many more products for this protein.
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Accordingly, medullary WNK4 protein levels were significantly increased in the kidneys of KLHL2(-/-) mice. KLHL2 is indeed a physiological regulator of WNK4 in vivo; however, its function might be different from that of KLHL3 because KLHL2 mainly localized in medulla.
These results suggest that KLHL2 likely plays a role in the pathogenesis of FHHt, and aggravates the phenotype caused by mutations in CUL3 and WNK4.
This study showed that KLHL2 is involved in the physiologic regulation of the WNK signal cascade.
Co-expression of KLHL2 and Cullin3 decreases the abundance of WNK1, WNK3 and WNK4 within HEK293T cells.
Results suggest a novel E3 ubiquitin ligase function of KLHL2, with NPCD as a substrate.
overexpression of Mayven may promote tumor growth through c-Jun and cyclin D1
May play a role in organizing the actin cytoskeleton of the brain cells.
kelch-like 2, Mayven
, kelch-like protein 2
, kelch-like 2, Mayven (Drosophila)
, actin-binding protein Mayven