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These results suggest a detrimental role of HLA-A-Bw4 and HLA-C2 groups, which are associated with the development of chronic hepatitis B, and a protective role of KIR2DL3.
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A minority (21%) of HLA-B( *)46:01 peptides, with common C-terminal characteristics, form ligands for KIR2DL3.
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KIR 2D (L1, L3, L4, S4) and KIR 3DL1 expression was correlated with poor prognosis in non-small cell lung carcinoma patients.
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CD16+ cells were significantly more frequent among Natural Killer (NK) cells negative for the inhibitory KIR (iKIR) KIR2DL1, KIR2DL3, and KIR3DL1 than those positive for any one of these iKIR to the exclusion of the others, making iKIR+ NK cells poorer antibody dependent cellular cytotoxicity effectors than iKIR- NK cells.
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These results show that 2DL3(+) NK cells are mediators of HIV-specific responses. Furthermore, responses of NK cell populations to iCD4 are influenced not only by NK cell education through specific KIR/HLA pairs, but also by differential HIV-mediated changes in HLA expression.
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Results identified three SNPs (S320F, H245Y, and H77Y) as highly deleterious in KIR2DL3 and nine SNPs (R157Q, H156Y, S63L, R157 W, F179 V, H128R, T101 M, R180C and F176I) in case of IFNL3, in coding region only with high conservation ranks highlighting the functional SNPs on phenotypic variability and disease susceptibility on HCV clearance candidate genes.
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KIR2DL2/KIR2DL3-glutamate(35) alleles are functionally stronger than -glutamine(35) alleles.
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KIR2DL2/2DS2-C1C1 genotype is associated with type 1 diabetes in Saudi children
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gene polymorphism is associated with Crohn's disease in Spanish patients
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study compared KIR gene repertoire of HIV-1 positive with exposed uninfected (EU)) infants to elucidate its association with transmission; results revealed presence of significantly high frequencies of activating gene KIR 2DS5 and inhibitory gene KIR 2DL3 in EU infants as compared to HIV-1 positive infants
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genetic association study in population in Eastern India: Data suggest that interactions between KIRs (KIR2DL2, KIR2DS4, KIR2DL3) and HLA ligands (HLAC1, HLAC2) contribute significantly toward susceptibility and protection toward type 1 diabetes.
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Allelic polymorphism of KIR2DL2/2DL3 in a southern Chinese population.
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The authors have identified a deleterious effect of the KIR2DL3-HLA-C1 receptor-ligand combination on HIV clinical outcomes in a Thai cohort.
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Single Nucleotide Polymorphism in KIR2DL3 gene is associated with Asthma and Atopic Dermatitis.
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KIR2DL3 has previously been identified as important for clearance of the Hepatitis C virus after established infection,not found to be relevant to resistance to Hepatitis C infection.
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Genetic risk for co-occurrence of type 1 diabetes and celiac disease is modified by HLA-C and killer immunoglobulin-like receptors.
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CD4(+) CD28(-) cells exhibited increased KIR2DS2, reduced KIR2DL3 and increased DAP12 expression in HD-ESRD compared with NDD-CKD patients.
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Authors showed an increase in HLA-C1/KIR2DL2 and HLA-C1/KIR2DL3 pairs in human papillomavirus high-risk infected patients (OR 3.05, 3.24) with invasive cervical cancer (OR 1.33, 3.68).
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KIR2DL3-positive NK cells were more sensitive to changes in the peptide content of MHC class I than KIR2DL2-positive NK cells.
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these results suggest that inhibitory KIR2DL2 and KIR2DL3, which are alleles of the same locus, play a role in the inverse effects on PM and PM/HIV co-infection
