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Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. Additionally we are shipping KIR3DL2 Antibodies (59) and KIR3DL2 Proteins (4) and many more products for this protein.
Overexpression of a single MHCI molecule, HLA-F (show HLAF ELISA Kits), protects human MNs (show FLNA ELISA Kits) from ALS (show IGFALS ELISA Kits) astrocyte-mediated toxicity, whereas knockdown of its receptor, the killer cell immunoglobulin-like receptor KIR3DL2, on human astrocytes results in enhanced motor neurons death
KIR-3DL2 binding to HLA-B27 licenses Th17 cell differentiation in spondyloarthritis.
In early axial spondyloarthritis and ankylosing spondylitis Dutch patients, no copy number changes were found for KIR3DL2.
we show that the allele KIR3DL2*001 and the single nucleotide polymorphism 1190T (rs3745902) are associated with differential susceptibility to pemphigus
CD158k expression was identified on cutaneous CD4 (show CD4 ELISA Kits)+ T cells in healthy individuals and also mycosis fungoides patients.
These findings provide novel insights about the molecular basis of KIR3DL2 binding to B27
these data provide evidence for a possible role of KIR3DL2 in the maintenance of a high circulating malignant-cell burden by preventing activation-induced cell death.
Our results indicate that KIR3DL2 can directly promote Sezary syndrome malignant cell death through the use of CpG ODN.
our results show that a multistep gating of CD158k+ cells is reliable to assess tumor burden in case of Sezary syndrome.
our results offer preclinical proof of concept for the clinical development of IPH4102, a humanized monoclonal antibody that targets the immune receptor KIR3DL2,to treat patients with nced cutaneous T-cell lymphoma
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules\\\\; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the 'framework' loci that is present on all haplotypes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
CD158 antigen-like family member K
, KIR antigen 3DL2
, MHC class I NK cell receptor
, killer Ig receptor
, killer cell immunoglobulin-like receptor 3DL2
, killer cell immunoglobulin-like receptor KIR3DL2
, natural killer cell inhibitory receptor
, natural killer-associated transcript 4
, p70 NK receptor CL-5
, p70 killer cell inhibitory receptor
, p70 natural killer cell receptor clone CL-5