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Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. Additionally we are shipping Killer Cell Lectin-Like Receptor Subfamily C, Member 2 Antibodies (59) and Killer Cell Lectin-Like Receptor Subfamily C, Member 2 Kits (1) and many more products for this protein.
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a 16kb deletion encompassing the NKG2C gene is associated with lower carotid intimal media thickness values and higher humoral and T-cell responses to cytomegalovirus in renal transplant recipients
the data of this study extend the characterization of adaptive NK cell subsets that differentiate in response to human Cytomegalovirus, supporting a relationship between their distribution and NKG2C copy number
The new method offers the potential to use SNP arrays from genome wide association studies to study the frequency of KLRC2 deletion in other populations and its association with other diseases
Assessment of NK cell repertoires in 60 NKG2C(-/-) donors revealed a broad range of NK cell populations displaying characteristic footprints of adaptive NK cells, including a terminally differentiated phenotype, functional reprogramming, and epigenetic remodeling of the interferon (IFN)-gamma (show IFNA Proteins) promoter.
HLA-E (show HLAE Proteins) regulates NKG2C+ natural killer cell function through presentation of a restricted peptide repertoire
Data suggest the proinflammatory potential of NKG2C(bright) NK cells.
lack of expression of NKG2C may be associated with altered control of human cytomegalovirus infection in childhood
No difference in the prevalence of NKG2C deletion was observed.
NKG2C receptor deletion and a functional polymorphism in its ligand HLA-E may play a role in psoriasis susceptibility
NKG2C(hi)CD57 (show B3GAT1 Proteins)+ NK cells respond specifically to acute infection with cytomegalovirus and not Epstein-Barr virus.
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The group, designated KLRC (NKG2) are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The KLRC (NKG2) gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. KLRC2 alternative splice variants have been described but their full-length nature has not been determined.
CD159 antigen-like family member C
, NK cell receptor C
, NKG2-C type II integral membrane protein
, NKG2-C-activating NK receptor