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Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. Additionally we are shipping Killer Cell Lectin-Like Receptor Subfamily D, Member 1 Antibodies (281) and Killer Cell Lectin-Like Receptor Subfamily D, Member 1 Proteins (17) and many more products for this protein.
Collectively, these results provide evidence for the first time that CD94/NKG2C (show KLRC2 ELISA Kits) is involved in chronic graft-versus-host disease prevention
CD94 and NKG2A (show KLRC1 ELISA Kits) polymorphisms may contribute to genetic susceptibility to rheumatoid arthritis or affect the response to anti-TNF (show TNF ELISA Kits) therapy in patients of Caucasian origin.
Coengagement of inhibitory receptors, either KIR2DL1 (show KIR2DL1 ELISA Kits) or CD94-NKG2A (show KLRC1 ELISA Kits), did not inhibit phosphorylation of Stat5 (show STAT5A ELISA Kits) but inhibited selectively phosphorylation of Akt (show AKT1 ELISA Kits) and S6 ribosomal protein (show RPS6 ELISA Kits).
it is not clear if high expression of CD94 on peripheral blood NK cells is related to abnormal activity of endometrial NK cells.
Data indicate that NKG2 receptor NKG2E (show KLRC3 ELISA Kits) was capable of associating with CD94 and DAP12 (show TYROBP ELISA Kits) but that the complex was retained intracellularly at the endoplasmic reticulum.
Balance between activating NKG2D (show KLRK1 ELISA Kits), DNAM-1 (show CD226 ELISA Kits), NKp44 (show NCR2 ELISA Kits) and NKp46 (show NCR1 ELISA Kits) and inhibitory CD94/NKG2A (show KLRC1 ELISA Kits) receptors determine natural killer degranulation towards rheumatoid arthritis synovial fibroblasts.
Data indicate that the expression of KLRD1 (CD94) and NKG2E (KLRC3 (show KLRC3 ELISA Kits)) was reduced in NK-enriched cells in fulminant type 1 diabetes.
NKG2C (show KLRC2 ELISA Kits) zygosity influences CD94/NKG2C (show KLRC2 ELISA Kits) receptor function and the NK-cell compartment redistribution in response to human cytomegalovirus.
Synergistic inhibition of natural killer cells by the nonsignaling molecule CD94.
Studies indicate that HLA-E (show HLAE ELISA Kits) interacts with CD94/NKG2 receptors expressed mainly on the surface of natural killer (NK) cells, thus confining its role to the regulation of NK-cell function.
These findings suggest that the CD94/NKG2A (show KLRC1 ELISA Kits) heterodimers in cattle, in contrast to other species, are binding several different ligands.
Segregation of a spontaneous Klrd1 mutation in DBA (show RPS19 ELISA Kits)/2 mouse substrains
The transmembrane region sequences of CD94 and NKG2 in mouse and rat differ markedly from other mammalian orthologs by the presence of a lysine residue in the transmembrane region.
The complex interplay between various stimuli may account for the variable expression of CD94/NKG2A (show KLRC1 ELISA Kits) during responses to different pathogens in vivo.
expression of CD94 and its associated NKG2A (show KLRC1 ELISA Kits), NKG2C (show KLRC2 ELISA Kits), and NKG2E (show KLRC3 ELISA Kits) subunits is dispensable for NK cell development, education, and many NK cell functions
show that CD94, a molecule preferentially expressed by NK cells, is essential for the resistance of C57BL/6 mice to mousepox, a disease caused by the Orthopoxvirus ectromelia virus
Implications of CD94 deficiency and monoallelic NKG2A (show KLRC1 ELISA Kits) expression for natural killer cell development and repertoire formation.
CD94 and NKG2 were both expressed early in NK cell development, sometimes in the absence of NK1.1, with CD94 invariably being expressed at two different levels. IL-4 differentially inhibited the expression of CD94 and Ly49 receptors.
Inhibitory receptor CD94 is expressed on mature fetal thymic and adult epidermal TCR Vgamma3+ lymphocytes.
The acquisition of individual receptor gene expressions during various stages of differentiation in culture from embryonic stem cells to NK cells follows a predetermined order, with the order of receptor acquisition being first CD94.
There is no evidence that CD94 inhibits either the lytic function of lymphocytic choriomeningitis virus-specific T cells or their capacity to produce effector cytokines upon peptide stimulation.
Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. Several genes of the C-type lectin superfamily, including members of the NKG2 family, are expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. Three transcript variants encoding two different isoforms have been found for this gene.
, NK cell receptor
, natural killer cells antigen CD94
, killer cell lectin-like receptor family D member 1
, killer cell lectin-like receptor subfamily D member 1
, Killer cell lectin-like receptor subfamily D member 1
, CD94 antigen (located within the rat natural killer gene complex)