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Location-regulated scaffolding protein connecting MEK to RAF. Additionally we are shipping Kinase Suppressor of Ras 1 Antibodies (104) and Kinase Suppressor of Ras 1 Kits (9) and many more products for this protein.
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the atypical C1 domain, the CC-SAM (show TTN Proteins) domain is required to target KSR-1 to the plasma membrane.
KSR is a scaffold required for activation of the ERK/MAPK (show MAPK1 Proteins) module.
Review discusses the possibility that KSR, a RAF (show ARAF Proteins)-like protein, does not solely act as a scaffold, but directly induces RAF (show RAF1 Proteins) catalytic function by a kinase-independent mechanism apparently shared by RAF (show RAF1 Proteins)-like proteins.
DiRas3 (show DIRAS3 Proteins) binds to KSR1 independently of its interaction with activated Ras and RAF (show RAF1 Proteins).
praja2 (show PJA2 Proteins) regulates KSR1 stability and mitogenic signaling.
These results suggest that Rap1 (show TERF2IP Proteins) activation of ERKs requires PKA phosphorylation and KSR binding.
Data show that caveolin-1 is necessary for optimal KSR1-dependent ERK activation by growth factors and oncogenic Ras.
propose that phosphorylation of Tyr (show TYR Proteins)(728) may regulate the transition between the scaffolding and the catalytic function of KSR1 serving as a control point used to fine-tune cellular responses
Data indicate that phosphorylation of BRAF (show BRAF Proteins) by AMPK (show PRKAA1 Proteins) disrupts its association with KSR1.
Despite its role in mTORC1 activation, KSR1 is not required in vivo for mTOR (show FRAP1 Proteins)-dependent T cell differentiation.
Ksr1 plays a dispensable role in lipopolysaccharide (LPS (show TLR4 Proteins))-induced ERK (show EPHB2 Proteins) activation in alveolar macrophages and does not contribute to the development of acute lung injury in the LPS (show TLR4 Proteins) model.
The loss of Ksr1 inhibits Ras/Mapk (show MAPK1 Proteins) pathway signaling leading to increased Myc (show MYC Proteins)-induced B-cell apoptosis, and this results in reduced B-cell transformation and lymphoma development.
Data show that neurofibromin 2 (Merlin (show NF2 Proteins)) suppresses proliferation and adhesion, at least partly, through inhibiting kinase suppressor of Ras 1 (KSR1) and DCAF1 protein.
These results suggest that Rap1 (show RABGEF1 Proteins) activation of ERKs requires PKA phosphorylation and KSR binding.
Upregulation of KSR1 is associated with Colorectal cancer.
the relative mRNA copy values of KSR1, ERK1 and ERK2 in the cancer tissues were 2.43 +/- 0.49, 2.10 +/- 0.44 and 3.65 +/- 0.94..EGb 761 enhanced the chemotherapy sensitivity through suppression of the KSR1-mediated ERK1/2 pathway in gastric cancer
KSR1 rs2241906 variants may predict survival in patients with advanced ERalpha (show ESR1 Proteins)+ BC treated with adjuvant TAM (show CCNA1 Proteins).
KSR1 is coordinately regulated with Notch (show NOTCH1 Proteins) signaling and oxidative phosphorylation in papillary thyroid cancer.
KSR1 stabilizes BRCA1 by reducing BRCA1 ubiquitination, inhibits tumor growth through BRCA1, and regulates BRCA1 stability via elevated BARD1 (show BARD1 Proteins) abundance and increased BRCA1-BARD1 (show BARD1 Proteins) interaction
Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. By itself, it has no demonstrated kinase activity.
, kinase suppressor of Ras85D
, suppressor of Ras1 3-1
, kinase suppressor of Ras 1
, protein Hb