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Location-regulated scaffold connecting MEK to RAF. Additionally we are shipping Kinase Suppressor of Ras 2 Antibodies (82) and Kinase Suppressor of Ras 2 Kits (9) and many more products for this protein.
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A pleiotropic effect of KSR2-rs7973260 was found on the risk of metabolic syndrome, severe hypertriglyceridemia, and diabetes.
KSR2 deficiency affects stromal interaction molecule 1 (STIM1 (show STIM1 Proteins))/ORAI1 puncta formation, which is correlated with cytoskeleton disorganization.
Study explored the role of KSR2 in humans by sequencing 2,101 individuals with severe early-onset obesity and identified multiple rare variants in KSR2 that disrupt signaling through the Raf (show RAF1 Proteins)-MEKERK pathway and impair cellular fatty acid oxidation and glucose oxidation in transfected cells.
study demonstrated that miR (show MLXIP Proteins)-31 upregulated IL-2 (show IL2 Proteins) expression via reduction of its up-stream kinase suppressor, KSR2, and is a component of T cell activation
The involvement of KSR2 in regulation of cell proliferation was predicted by a KSR2-centered network analysis.
KSR (show KSR1 Proteins) interacts with a regulatory Raf (show RAF1 Proteins) molecule in cis (show CISH Proteins) to induce a conformational switch of MEK (show MAP2K1 Proteins), facilitating MEK's phosphorylation by a separate catalytic Raf (show RAF1 Proteins) molecule in trans
Oncoprotein Cot1 represses kinase suppressors of Ras1/2 and 1,25-dihydroxyvitamin D3-induced differentiation of human acute myeloid leukemia (show BCL11A Proteins) cells.
hKSR-2, a new member of the KSR (show KSR1 Proteins) family, negatively regulates Cot (show MAP3K8 Proteins)-mediated MAP kinase (show MAPK1 Proteins) and NF-kappaB (show NFKB1 Proteins) pathway signaling
We find that while hKSR-2 blocks MEKK3 (show MAP3K3 Proteins) activation, it has little to no effect on other members of the MAP3K family, including MEKK4 (show MAP3K4 Proteins), TAK1 (show MAP3K7 Proteins), and Ras-Raf (show RAF1 Proteins), suggesting that its effects are selective.
These results demonstrate that kinase suppressor of Ras 2 is a direct target of 1,25-dihydroxyvitamin D(3)in HL60 cells, and is required for optimal monocytic differentiation.
These data indicate that KSR2 functions in a cell non-autonomous fashion to regulate GH-stimulated IGF-1 (show IGF1 Proteins) expression in the liver of neonatal mice, which plays a key role in the development of body length.
KSR2 deficiency affects stromal interaction molecule 1 (STIM1 (show STIM1 Proteins))/ORAI1 (show TMEM132A Proteins) puncta formation, which is correlated with cytoskeleton disorganization.
KSR2 is essential to tumor cell energy homeostasis and critical to the integration of mitogenic and metabolic signaling pathways
The metabolic phenotype of KSR2 heterozygous (KSR2(+/minus;)) and KSR2(-/-) mice suggests that human KSR2 variants may contribute to a similar phenotype linked to human chromosome 12q24
KSR2 regulates AMPK (show PRKAA1 Proteins)-dependent glucose uptake and fatty acid oxidation in mouse embryonic fibroblasts and glycolysis in a neuronal cell line.
The protein phosphatase calcineurin selectively interacts with KSR2 and KSR2 uniquely contributes to Ca2 (show CA2 Proteins)+-mediated ERK (show EPHB2 Proteins) signaling.
Location-regulated scaffold connecting MEK to RAF. Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.
kinase suppressor of Ras 2