Kruppel-Like Factor 11 Proteins (KLF11)

The protein encoded by KLF11 is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. Additionally we are shipping KLF11 Antibodies (87) and KLF11 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KLF11 8462 O14901
KLF11 194655 Q8K1S5
Rat KLF11 KLF11 313994  
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Top KLF11 Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,626.73
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Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,626.73
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Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$338.33
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KLF11 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Kruppel-Like Factor 11 (KLF11) Interaction Partners

Human Kruppel-Like Factor 11 (KLF11) interaction partners

  1. Profibrotic gene expression was activated in a primary human peritoneal cell line in response to KLF11 short hairpin RNA and medroxyprogesterone acetate but not estradiol.

  2. In endometrial-stromal fibroblasts, KLF11 recruited SIN3A/HDAC (histone deacetylase), resulting in COL1A1-promoter deacetylation and repression

  3. Results suggest a role for KLF11 in upregulating MAO-A in depressive disorder and chronic social stress, suggesting that inhibition of the pathways regulated by this transcription factor may aid in the therapeutics of neuropsychiatric illnesses

  4. The data suggest a relationship between promoter DNA methylation and KLF11 gene expression in ovarian cancer tumorigenesis.

  5. identified an evolutionarily conserved metabolic regulator, Kruppel-like factor 11 (KLF11), as a novel browning transcription factor in human adipocytes that is required for rosiglitazone-induced browning.

  6. KLF11 repressed most endometrial CYP enzymes

  7. Levels of KLF11 are significantly increased in the postmortem prefrontal cortex of subjects with alcohol dependence compared to controls.

  8. KLF11 regulates distinct gene networks.

  9. KLF111 represses glycodelin-A levels and influences its role in the ovarian endometrium.

  10. KLF11 is a critical transcription factor in the function of mesenchymal cells and, specifically, as a negative regulator of collagen secretion.

  11. Data identify a novel pathogenic role for KLF11 in preventing de novo disease-associated fibrosis in endometriosis.

  12. The A347S mutation disrupted KLF11-mediated increases in basal insulin levels and promoter activity and blunted glucose-stimulated insulin secretion.

  13. Data indicate that median methylation levels of BCAN, HOXD1, KCTD8, KLF11, NXPH1, POU4F1, SIM1, and TCF7L1 were >/=30% higher than in normal samples, representing potential biomarkers for tumor diagnosis.

  14. KLF11 has a role in fine-tuning insulin transcription in certain cellular situations rather than representing a major transcriptional activator or repressor of the insulin gene.

  15. Kruppel-like factor-11, a transcription factor involved in diabetes mellitus, suppresses endothelial cell activation via the nuclear factor-kappaB signaling pathway.

  16. KLF11 is an MAO A regulator and is produced in response to neuronal stress, which transcriptionally activates MAO A.

  17. Here we report the characterization of two antagonistic, chromatin-mediated mechanisms by which KLF11 regulated the transcription of the dopamine D2 receptor.

  18. A PXVXL HP1-interacting domain identified at position 487-491 of KLF11 mediates the binding of HP1alpha and KLF11 in vitro and in cultured cells.

  19. an important role for KLF11 in the regulation of INS transcription via the novel c.-331 KLF site.

  20. KLF11, but not KLF15, was essential for UCP1 expression during brown adipocyte differentiation of muBM3.1.

KLF11 Protein Profile

Protein Summary

The protein encoded by this gene is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene.

Gene names and symbols associated with Kruppel-Like Factor 11 Proteins (KLF11)

  • Kruppel like factor 11 (KLF11)
  • Kruppel-like factor 11 (Klf11)
  • Kruppel-like factor 11 L homeolog (klf11.L)
  • Kruppel-like factor 11a (klf11a)
  • Kruppel-like factor 11 (klf11)
  • Krueppel-like factor 11 (LOC100194692)
  • Kruppel like factor 11 (Klf11)
  • Kruppel-like factor 11b (klf11b)
  • 9830142A17 protein
  • D12Ertd427e protein
  • fklf protein
  • fklf1 protein
  • klf11 protein
  • MGC145216 protein
  • mody7 protein
  • si:dkey-81b15.5 protein
  • Tcfcp2l2 protein
  • TIEG-2 protein
  • tieg2 protein
  • Tieg2b protein
  • tieg3 protein
  • wu:fc45c07 protein
  • wu:fj44b12 protein
  • zgc:153255 protein
  • zgc:154048 protein

Protein level used designations for Kruppel-Like Factor 11 Proteins (KLF11)

Krueppel-like factor 11 , TGFB-inducible early growth response protein 2 , TIEG-2 , transforming growth factor-beta-inducible early growth response protein 2 , TGFB inducible early growth response 2 , TGFB inducible early growth response 3 , TGFB-inducible early growth response protein 2b , TGFB-inducible early growth response protein 3 , TIEG-3 , transforming growth factor-beta-inducible early growth response protein 3 , transcription factor CP2-like 2 , Kruppel-like factor 11 , TIEG2 , TGF-beta inducible early growth response protein 2 , novel kruppel-like factor family protein , krueppel-like factor 11-like , Krueppel-like factor 11-like , Kruppel-like factor 11b

GENE ID SPECIES
8462 Homo sapiens
194655 Mus musculus
313994 Rattus norvegicus
421934 Gallus gallus
444439 Xenopus laevis
459023 Pan troglodytes
475665 Canis lupus familiaris
560787 Danio rerio
616730 Bos taurus
702323 Macaca mulatta
733909 Xenopus (Silurana) tropicalis
100031998 Monodelphis domestica
100174954 Sus scrofa
100194692 Salmo salar
100436340 Pongo abelii
100465756 Ailuropoda melanoleuca
100607386 Nomascus leucogenys
100715755 Cavia porcellus
100072433 Equus caballus
559076 Danio rerio
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