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KLF6 encodes a member of the Kruppel-like family of transcription factors. Additionally we are shipping KLF6 Antibodies (47) and many more products for this protein.
Showing 10 out of 12 products:
Human KLF6 Protein expressed in Wheat germ - ABIN1308760
Huang, Li, Guo: KLF6 induces apoptosis in prostate cancer cells through up-regulation of ATF3. in The Journal of biological chemistry 2008
DJ-1 (show PARK7 Proteins) knockdown increased KLF6 expression in bortezomib-resistant myeloma cells, and subsequent siRNA-mediated KLF6 knockdown rescued bortezomib-resistant myeloma cells from undergoing cell death.
Our study provides new evidence that interaction of KLF6 and Sp1 regulates basigin-2 expression in hepatocellular carcinoma
MIIP (show MIIP Proteins) and PAK1 (show PAK1 Proteins) bind each other and a C-terminal polyproline domain of MIIP (show MIIP Proteins) is required for PAK1 (show PAK1 Proteins) binding. Ectopically expressed MIIP (show MIIP Proteins) consistently competed with Rac1-GTP (show AK3 Proteins) for binding with the PAK1 (show PAK1 Proteins) p21 (show CDKN1A Proteins)-binding domain in endometrial cancer cells.
hypoxia induced an early and transient increase in KLF6 protein levels in HTR8/SVneo extravillous cytotrophoblast cells and in placental explants. Reoxygenation returned KLF6 protein to basal levels. Moreover, hypoxia-induced up-regulation of KLF6 expression was dependent on HIF-1alpha (show HIF1A Proteins). These results indicate that KLF6 may mediate some of the effects of hypoxia in placental development.
The study highlights the central role of myeloid KLF6 in promoting intestinal inflammation.
study identifies a new mechanism by which KLF6 regulates NF-kappaB (show NFKB1 Proteins) signaling, and how this mechanism is circumvented in glioblastoma through KLF6 loss.
our results established the significance of activating the KLF6-E2F1 (show E2F1 Proteins) axis in aggressive primary metastatic clear cell renal cell carcinoma (show MOK Proteins)
KLF6 overexpression suppressed the xenograft tumor growth.
KLF6 and KLF15 are targeted and suppressed in breast cancer cells by miR (show MLXIP Proteins)-4262.
KLF6 acts as a tumor suppressor in CMM cells and miR (show MLXIP Proteins)-4262 promotes the proliferation of CMM cells through KLF6-mediated EGFR (show EGFR Proteins) inactivation and p21 (show CDKN1A Proteins) upregulation.
KLF6-mediated activation of the human INSL3 (show INSL3 Proteins) promoter required an intact KLF element as well as Leydig/Sertoli-enriched factors. KLF6 transcriptionally cooperates with NUR77 (show NR4A1 Proteins) and SF1 (show SF1 Proteins). our results identify KLF6 as a regulator of human INSL3 (show INSL3 Proteins) transcription.
we identified novel transcriptional targets of KLF6 in HCC cells including VAV3, a known activator of the RAC1 small GTPase. Indeed, RAC1 activity is increased in KLF6-knockdown cells in a VAV3-dependent manner, and knockdown of either RAC1 or VAV3 impairs HCC cell migration. Together, our data demonstrate a novel function for KLF6 in constraining HCC dissemination through the regulation of a VAV3-RAC1 signaling axis.
Klf6 as required for developmental central nervous system myelination.Klf6 promotes oligodendrocyte differentiation and viability.
observations reveal that KLF6 repress BCL6 (show BCL6 Proteins) to enhance macrophage inflammatory gene expression and function.
present studies on the cardiac function of KLF6 show a new mechanism whereby cardiomyocytes regulate cardiac fibrosis through transcriptional control of the extracellular matrix factor thrombospondin 4 (show THBS4 Proteins)
downregulates expression and secretion of granulocyte macrophage colony-stimulating factor (show CSF2 Proteins)
KLF6-dependent regulation of the cytochrome c (show CYCS Proteins) oxidase assembly gene is critical for maintaining mitochondrial function and preventing podocyte apoptosis.
findings provide novel evidence highlighting KLF6 function in response to malignant transformation, suggesting the relevance of KLF6 in controlling cell proliferation and hindering tumorigenesis
KLF6 is required for optimal LPS (show TLR4 Proteins)-induced pro-inflammatory gene expression, acting cooperatively with NF-kappaB (show NFKB1 Proteins)
Klf6a promotes hematopoietic stem and progenitor cell maintenance through Ccl25b-Ccr7 (show CCR7 Proteins) chemokine (show CCL1 Proteins) signaling.
In the spinal cord, klf7 (show KLF7 Proteins)- and klf6a-expressing cells are found in both the dorsal and ventral horns. Numerous sensory structures (e.g. auditory, lateral line, olfactory and visual) and several motor nuclei (e.g. oculomotor, trigeminal, and vagal motor nuclei) contain klf7 (show KLF7 Proteins)- and/or klf6a-expressing cells
copeb/Klf6 is essential for the development of endoderm-derived organs
This gene encodes a member of the Kruppel-like family of transcription factors. The zinc finger protein is a transcriptional activator, and functions as a tumor suppressor. Multiple transcript variants encoding different isoforms have been found for this gene, some of which are implicated in carcinogenesis.
Kruppel-like factor 6
, core promoter element binding protein
, Krueppel-like factor 6
, krueppel-like factor 6
, B-cell-derived protein 1
, GC-rich binding factor
, GC-rich sites-binding factor GBF
, Kruppel-like zinc finger protein Zf9
, core promoter element-binding protein
, proto-oncogene BCD1
, protooncogene B-cell derived 1
, suppression of tumorigenicity 12 (prostate)
, suppressor of tumorigenicity 12 protein
, transcription factor Zf9
, immediate early response, erythropoietin 1