anti-LEM Domain Containing 3 (LEMD3) Antibodies

This locus encodes a LEM domain-containing protein. Additionally we are shipping LEM Domain Containing 3 Kits (4) and LEM Domain Containing 3 Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
LEMD3 23592 Q9Y2U8
LEMD3 380664 Q9WU40
LEMD3 680066  
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Top anti-LEM Domain Containing 3 Antibodies at antibodies-online.com

Showing 10 out of 22 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Dog Mouse Un-conjugated FACS, IF, IHC, IHC (p), WB 100 μL Log in to see 11 to 14 Days
$507.83
Details
Dog Mouse Un-conjugated FACS, IF, WB 100 μL Log in to see 11 to 14 Days
$522.50
Details
Human Rabbit Un-conjugated ELISA, IF, IHC, IHC (p), WB Anti-LEMD3 / MAN1 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 50 μg Log in to see 11 to 14 Days
$484.00
Details
Human Mouse Un-conjugated FACS, WB HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY LEMD3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-LEMD3. Flow cytometric Analysis of Hela cells, using anti-LEMD3 antibody (ABIN2453808), (Red), compared to a nonspecific negative control antibody, (Blue). 0.1 mL Log in to see Available
$451.00
Details
Human Rabbit Un-conjugated EIA, IF, IHC (p), WB   0.1 mg Log in to see 8 to 11 Days
$474.10
Details
Human Rabbit Un-conjugated ELISA, IHC, WB Immunohistochemical analysis of LEMD3 in human colon tissue with LEMD3 polyclonal antibody  at 2.5 ug/mL. Western blot analysis of LEMD3 in human colon tissue with LEMD3 polyclonal antibody  at 1 ug/mL. 100 μg Log in to see 11 to 12 Days
$349.54
Details
Human Mouse Un-conjugated FACS, IF, IP, IHC, WB HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY LEMD3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-LEMD3. Immunohistochemical staining of paraffin-embedded liver tissue using anti-LEMD3mouse monoclonal antibody. (ABIN2453228, Dilution 1:50) 0.1 mL Log in to see Available
$451.00
Details
Human Mouse Un-conjugated IF, IP, WB Anti-LEMD3 mouse monoclonal antibody (ABIN2453229) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY LEMD3 (RC212759). HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY LEMD3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-LEMD3. 0.1 mL Log in to see Available
$451.00
Details
Human Mouse Un-conjugated FACS, IF, IP, IHC, WB Immunohistochemical staining of paraffin-embedded breast tissue using anti-LEMD3 mouse monoclonal antibody. (ABIN2453231, Dilution 1:50) Immunohistochemical staining of paraffin-embedded colon tissue using anti-LEMD3mouse monoclonal antibody. (ABIN2453231, Dilution 1:50) 0.1 mL Log in to see Available
$451.00
Details
Human Mouse Un-conjugated FACS, IF, IP, WB Anti-LEMD3 mouse monoclonal antibody (ABIN2453230) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY LEMD3 (RC212759). HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY LEMD3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-LEMD3. 0.1 mL Log in to see Available
$482.90
Details

More Antibodies against LEM Domain Containing 3 Interaction Partners

Human LEM Domain Containing 3 (LEMD3) interaction partners

  1. studies demonstrated that lower levels of MAN1 in differentiating MSC are associated with higher osteogenesis and lower adipogenesis. High levels of MAN1 only affected adipogenesis.

  2. LAMD3 Y871X mutation is associated with osteopoikilosis.

  3. Letter/Case-Report: novel frameshift mutation in RNA recognition motif of LEMD3 in patient with Buschke-Ollendorff syndrome.

  4. A novel mutation in LEMD3 splice site results in Buschke-Ollendorff syndrome.

  5. Data indicate that the inner nuclear membrane protein MAN1 directly binds the transcription activator BMAL1 promoter and enhances its transcription.

  6. a nuclear envelope-localized mechanism of inactivating TGF-beta signaling in which MAN1 competes with transcription factors for binding to Smad2 and Smad3 and facilitates their dephosphorylation by PPM1A.

  7. The absence of direct binding of BAF to MAN1-C eliminates disruption of this interaction as the cause of the premature aging phenotype.

  8. Genetic analyses of three generations of a family with Buschke-Ollendorff syndrome having a variable phenotype showed a novel c.2203C>T nonsense mutation at the LEMD3 locus. The mutation induced a change in the 735 arginine codon to a stop codon.

  9. Buschke-Ollendorff syndrome in a three-generation family: influence of a novel LEMD3 mutation to tropoelastin expression.

  10. We found a novel c.2203C > T (p.R735X) mutation in exon 9 of LEMD3, resulting in a premature stop codon at amino acid position 735.

  11. Absence of LEMD3 mutation in the exons and splice sites of a family with BOS suggests that there is genetic heterogeneity for this disorder.

  12. The C-terminal domain of human MAN1 binds to Smad2 and Smad3 and antagonizes signaling by transforming growth factor-beta

  13. Overexpression results in inhibition of R-Smad phosphorylation, heterodimerization with Smad4, and nuclear translocation

  14. Data describe the direct binding of the nuclear membrane protein MAN1 to emerin in vitro.

  15. germline LEMD3 mutations are rare in sporadic patients with isolated melorheostosis

  16. MAN1 binds simultaneously to R-Smads and their targeted DNA sequences

  17. novel mutation associated with familial cutaneous collagenomas

  18. novel heterozygous splice-site mutation in a Japanese kindred with Buschke-Ollendorff syndrome

  19. The LEMD3 mutation reported was clearly the cause of osteopoikilosis in the two families but its relationship to melorheostosis in one of the family members is still unclear.

  20. Identified two mutations in the two cases of Buschke-Ollendorff syndrome. The mutation (c.2564G>A) is novel. The present study supports the general conclusion that LEMD3 mutations do not contribute to isolated sporadic melorheostosis.

Pig (Porcine) LEM Domain Containing 3 (LEMD3) interaction partners

  1. Genome-wide analysis combined with linkage results revealed LEMD3 and WIF1 as the candidates for porcine ear size.

Xenopus laevis LEM Domain Containing 3 (LEMD3) interaction partners

  1. LEM proteins, involved in signalling essential for organ development during early embryogenesis and suggests that loss of MAN1 may cause muscle and retina specific diseases

LEM Domain Containing 3 (LEMD3) Antigen Profile

Protein Summary

This locus encodes a LEM domain-containing protein. The encoded protein functions to antagonize transforming growth factor-beta signaling at the inner nuclear membrane. Two transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been associated with osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis.

Gene names and symbols associated with LEMD3

  • LEM domain containing 3 (LEMD3) antibody
  • LEM domain containing 3 (Lemd3) antibody
  • LEM domain containing 3 (lemd3) antibody
  • LEM domain containing 3 S homeolog (lemd3.S) antibody
  • AI316861 antibody
  • im:7158446 antibody
  • lemd3 antibody
  • man1 antibody
  • RGD1561001 antibody
  • sane antibody
  • si:dkey-6a5.6 antibody
  • wu:fb34b12 antibody
  • xman1 antibody

Protein level used designations for LEMD3

LEM domain-containing protein 3 , inner nuclear membrane protein Man1 , integral inner nuclear membrane protein , integral inner nuclear membrane protein MAN1 , LEM domain containing 3 , Smad1 antagonistic effector , LEM domain containing 3 S homeolog , nuclear membrane protein XMAN1

GENE ID SPECIES
23592 Homo sapiens
380664 Mus musculus
417832 Gallus gallus
452050 Pan troglodytes
530659 Bos taurus
558474 Danio rerio
608380 Canis lupus familiaris
680066 Rattus norvegicus
717597 Macaca mulatta
100038042 Xenopus (Silurana) tropicalis
100079476 Ornithorhynchus anatinus
100346960 Oryctolagus cuniculus
100402143 Callithrix jacchus
100441107 Pongo abelii
100511508 Sus scrofa
100553511 Anolis carolinensis
398582 Xenopus laevis
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