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LHX1 encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. Additionally we are shipping LIM Homeobox 1 Antibodies (84) and LIM Homeobox 1 Kits (10) and many more products for this protein.
Showing 9 out of 9 products:
Report novel missense mutation in LHX1 in congenital absence of the uterus and vagina which could change the transcriptional activity of LHX1 and its effect on the regulation of the downstream target gene GSC (show GSC Proteins).
Our MRKH families included 43 quads, 26 trios, and 30 duos. Of our MRKH probands, 87/147 (59%) had MRKH type 1 and 60/147 (41%) had type 2 with additional anomalies. CONCLUSION(S): Although the prevalence of WNT4 (show WNT4 Proteins), HNF1B (show HNF1B Proteins), and LHX1 point mutations is low in people with MRKH, the prevalence of CNVs was approximately 19%.
Data have identified TBX6 (show TBX6 Proteins) as a new gene associated with Mullerian aplasia. The results also support the relevance of LHX1 and CNVs in the development of this congenital malformation.
study concludes that heterozygous mutations of LHX1 might be one cause of the Mayer-Rokitansky-Kuster-Hauser syndrome in a subgroup of patients
Data indicate that expression of ERAS, LHX1, and CCRK (show CDK20 Proteins) is increased in aggressive subgroups of medulloblastomas.
Lim1/LIM1 expression in neonatal, adult mouse and human endometrium suggesting Lim1/LIM1 may have a role in endometrial development and remodelling
Mutations in the coding regions of LHX1 may not be a common genetic etiologic factor involved in Han Chinese patients with mullerian duct abnormalities.
Eleven dysplastic kidneys showed no expression of LIM1. In contrast, 12 of 32 nephroblastomas showed nuclear positivity.
findings establish that the developmental marker Lim1 acts as an oncogene in cancer cells and targeting Lim1 may constitute an innovative therapeutic intervention in human lear cell carcinoma
Lim1 (also known as Lhx1) gene consists of a DNA-binding homeodomain and 2 cysteine-rich LIM (show PDLIM5 Proteins) domains, which may participate in protein to protein interactions, and encodes a transcription factor.
Loss of LHX1 is associated with loss of acute light control of sleep.
Smad4 (show SMAD4 Proteins)/Eomes (show EOMES Proteins)-dependent Lhx1 expression in the epiblast marks the entire definitive endoderm lineage, the anterior mesendoderm, and midline progenitors.
LHX1 is required in the anterior mesendoderm, but not in the mesoderm, for formation of the head.
Lhx1 maintains synchrony among circadian oscillator neurons of the suprachiasmatic nucleus.
Lhx1 is necessary for SCN (show SRI Proteins) terminal differentiation, including expression of neuropeptides profoundly important for circadian function.
OTX2 (show OTX2 Proteins) has a role in regulating Dkk1 (show DKK1 Proteins) and Lhx1 activity in the anterior mesendoderm
These studies identify LHX1 as the first transcription factor that is essential in the Mullerian duct epithelial progenitor cells for female reproductive tract development.
a core regulatory subcircuit composed of Pax2/8, Gata3 and Lim1 turns on a deeper layer of transcriptional regulators while activating effector genes responsible for cell signaling and tissue organization.
Lhx1 therefore may influence the localization of primordial germ cells by modulating Ifitm1 (show IFITM1 Proteins)-mediated repulsive activity.
Inactivation of either PINCH (show LIMS1 Proteins) isoform independently leads to instability of ILK (show ILK Proteins), loss of stretch-responsive anf (show HESX1 Proteins) and vegf (show VEGFA Proteins) expression, and progressive heart failure
These results demonstrate an essential role for Lhx1 in driving specification of the entire kidney field from the intermediate mesoderm.
nephrogenic transcription factors (osr1 (show OSR1 Proteins), osr2, hnf1b (show HNF1B Proteins), lhx1, pax8 (show PAX8 Proteins))play important role in nephrogenesis but have no pronephros induction potential upon overexpression; they activate transcription cascades reflecting activation by activin A (show INHBA Proteins), retinoic acid
Substantial evidence is found for a prosomeric organization of the diencephalon based on alternating expression of Lhx1/5 and Lhx2 (show LHX2 Proteins)/9 genes during larval development and in the adult.
This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor important for the development of the renal and urogenital systems. This gene is a candidate for Mayer-Rokitansky-Kuster-Hauser syndrome, a disorder characterized by anomalies in the female genital tract.
LIM homeobox protein 1
, LIM/homeobox protein Lhx1
, homeobox protein Lim-1
, LIM homeo box protein 1
, domesticus (clone 2.3 kB) lim-1
, Homeobox protein LMX-2
, Homeobox protein Lim-1