LIM Homeobox 3 Proteins (LHX3)

LHX3 encodes a member a large protein family which carry the LIM domain, a unique cysteine-rich zinc-binding domain. Additionally we are shipping LHX3 Antibodies (28) and LHX3 Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LHX3 8022 Q9UBR4
Rat LHX3 LHX3 170671  
LHX3 16871 P50481
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Top LHX3 Proteins at antibodies-online.com

Showing 7 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,749.58
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,749.58
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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Yeast Wild boar His tag   1 mg Log in to see 60 to 71 Days
$3,054.33
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Yeast Xenopus laevis His tag   1 mg Log in to see 60 to 71 Days
$3,091.00
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Yeast Chicken His tag   1 mg Log in to see 60 to 71 Days
$3,091.00
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Yeast Zebrafish His tag   1 mg Log in to see 60 to 71 Days
$3,102.00
Details

LHX3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for LIM Homeobox 3 (LHX3) Interaction Partners

Human LIM Homeobox 3 (LHX3) interaction partners

  1. Study did not identify HESX1 and LHX3 mutations by Sanger in brazilian patients with combined pituitary hormone deficiency

  2. Further functional studies show that forced expression of LHX3 in lung cancer cells obviously promotes cell proliferation and invasion, whereas inhibits cell apoptosis. In summary, LHX3 is an early-stage and radiosensitivity prognostic biomarker, and a novel potential oncogene in lung adenocarcinoma .

  3. investigated the specific mutations in PROP1, POU1F1, LHX3, and HESX1 genes in patients with combined pituitary hormone deficiency (CPHD) in Turkey

  4. LHX3 is upregulated in high-grade oligodendroglioma.

  5. The downstream enhancer region of LHX3 in regulating gene expression at the cellular level during development, is reported.

  6. Data suggest that low serum FSH (follicle stimulating hormone) levels in men with SNP in promoter region of FSHB (FSH beta subunit; -211G/T) result from reduced LHX3 binding to FSHB promoter and down-regulation of FSHB transcription in gonadotrophs.

  7. The present study was unable to confirm a significant association of all of the three SNPs, rs12338076 in LHX3-QSOX2, and rs1457595 and rs17032362 in IGF1, with adult height in our study population.

  8. descriprion of pediatric patients with combined pituitary hormone deficiency with a novel mutation in LHX3; the T194R mutation affects a critical residue in the LHX3 protein; study extends understanding of phenotypic features, molecular mechanism and developmental course associated with mutations in the LHX3 gene

  9. This study of the first nonconsanguineous patient with LHX3 mutations demonstrates the pleiotropic roles of LHX3 during development and its full involvement in the complex disease phenotype of syndromic combined pituitary hormone deficiency.

  10. This study establishes ISL1 as a novel transcriptional regulator of LHX3 and describes a potential mechanism for regulation by PITX1.

  11. LHX3 mutations are a rare cause of hypopituitarism. We report on a patient with a novel LHX3 mutation in exon 2 with the phenotype of combined pituitary hormone deficiency with short neck and sensorineural hearing impairment. [review]

  12. A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci.

  13. "Mutations in LHX3 are associated with a short neck combination with GHD (growth hormone deficiecy), PRL(prolactin) and TSH (thyroid stimulating hormone) and gonadotropin deficiency" p. 278

  14. "Mutations within LHX3 are associated with recessive combined pituitary hormone deficiency, with sparing of cortisol secretion..." P. 207

  15. LHX3 LIM homeodomain transcription factor is involved in activation of the FSH beta-subunit gene in the pituitary gonadotrope cell.

  16. identified unique amino acids within LHX3 that are important for its transcriptional activity and are phosphorylated

  17. LHX3 is expressed at all stages of early development.

  18. Specificity protein 1 is a regulator of both promoters through interaction with GC boxes and also, a distal element within intron 1a that is recognized by nuclear factor I is critical for hLHX3b promoter function.

  19. The presence of a hypointense pituitary lesion and other clinical findings broadens the phenotype associated with LHX3 gene mutation.

  20. Lhx3expression of Isl-1 and Lhx3, together with steroidogenic factor 1 (SF-1), culminates in the activation of both the rat as well as human GnRH-R promoter, suggesting that this combination is evolutionarily conserved among mammals

Zebrafish LIM Homeobox 3 (LHX3) interaction partners

  1. Lhx3 and Lhx4 have roles in suppressing Kolmer-Agduhr interneuron characteristics within zebrafish axial motoneurons

Pig (Porcine) LIM Homeobox 3 (LHX3) interaction partners

  1. LHX3 LIM homeodomain transcription factor is involved in activation of the FSH beta-subunit gene in the pituitary gonadotrope cell.

Cow (Bovine) LIM Homeobox 3 (LHX3) interaction partners

  1. Association analysis indicated that the some SNPs studied are associated with the body weight at 6, 12 and 18months of age in Nanyang cattle (P<0.01 or P<0.05), providing evidence that some SNPs in LHX3 gene may be associated with body weight at certain ages.

  2. The isolation and characterization of three polymorphisms of LHX3 are reported.

Mouse (Murine) LIM Homeobox 3 (LHX3) interaction partners

  1. Results show that specific genomic loci associated with Islet-1 (Isl1) , LIM-homeobox 3 (Lhx3), and LMO4 genes recruit the Isl1-Lhx3 complex to activate the transcription of Isl1, Lhx3, and Lmo4.

  2. Together, the authors show the antagonistic regulation of the alpha-enhancer activity by Pax6 and the LIM protein complex is necessary for the establishment of an inner retinal circuitry, which controls visual adaptation.

  3. conditional deletion of Shh in the anterior hypothalamus results in a fully penetrant phenotype characterised by a complete arrest of (Rathke's pouch) RP development, with lack of Lhx3/Lhx4 expression in RP epithelium.

  4. Expression of motor neuron effector genes is maintained by transient enhancers bound by Isl1/Lhx3 in nascent motor neurons and Isl1/Onecut1 in maturing hypaxial motor neurons.

  5. All E1 sequences from lamprey to mouse responded equally well to Phox2a and the Isl1-Lhx3 complex. Conversely, E2, the enhancer for limb-innervating motor neurons, was only found in tetrapod animals

  6. We discovered that expression of Cdkn1a is expanded dorsally in the pituitary primordium of both Lhx3 and Lhx4 mutants.

  7. Lhx3-LIM domains play critical roles in transactivation of the Isl1-Lhx3 complex by not only directing the assembly of the Isl1-Lhx3 complex but also recruiting coactivators to the complex.

  8. This treatment leads to activation of Lhx3 gene expression.

  9. LHX3 interacts with inhibitor of histone acetyltransferase complex subunits LANP and TAF-1beta to modulate pituitary gene regulation.

  10. The results of this study suggested that Lhx3/Chx10 medullary reticular formation neurons are involved in locomotion.

  11. Data characterized an intramolecular interaction between the LIM domains and LIM homeobox 3 (Lhx3)-binding domain in Isl1.

  12. Solution structure of the LIM-homeodomain transcription factor complex Lhx3/Ldb1 and the effects of a pituitary mutation on key Lhx3 interactions.

  13. Isl1-Lhx3, a LIM-complex mimicking fusion, induces a signature of motor neuron transcriptome & suppresses interneuron differentiation programs. An equimolar ratio of Isl1 & Lhx3 & the LIM domain of Lhx3 are crucial for this.

  14. X-ray crystal- and small-angle x-ray scattering-derived solution structures of an Lhx4.Isl2 complex exhibit many similarities with that of Lhx3.Isl1; structural differences supported by mutagenic studies reveal differences in the mechanisms of binding.

  15. LHX3 gene encodes a LIM-homeodomain transcription factor, which has essential roles in pituitary and nervous system development in mammals.

  16. LIM factor Lhx3 contributes to the specification of motor neuron and interneuron identity through cell-type-specific protein-protein interactions

  17. study demonstrates a functional role for LHX3 in the regulation of the GnRH receptor

  18. underscore the view that Lhx3 functions downstream of the Pitx factors in the same transcriptional cascade that controls growth and early cell differentiation of the developing pituitary gland

  19. These overexpression studies provide insights into the properties of LHX3 during pituitary development and highlight the importance of this factor in reproductive physiology.

  20. analysis of expression of LHX3 and SOX2 during mouse inner ear development

LHX3 Protein Profile

Protein Summary

This gene encodes a member a large protein family which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor that is required for pituitary development and motor neuron specification. Mutations in this gene cause combined pituitary hormone deficiency 3. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with LIM Homeobox 3 Proteins (LHX3)

  • lim homeobox 3 (LOC662120)
  • LIM/homeobox protein Lhx3 (LOC100224079)
  • LIM homeobox 3 (LHX3)
  • LIM homeobox 3 (Lhx3)
  • LIM homeobox 3 (lhx3)
  • LIM homeobox 3 L homeolog (lhx3.L)
  • LIM homeobox protein 3 (Lhx3)
  • CPHD3 protein
  • lim-3 protein
  • Lim3 protein
  • M2-LHX3 protein
  • mLim-3 protein
  • mLIM3 protein
  • P-LIM protein
  • xlim-3 protein

Protein level used designations for LIM Homeobox 3 Proteins (LHX3)

lim homeobox 3 , LIM homeobox 3 , LIM homeobox protein 3 , LIM/homeobox protein Lhx3 , LIM/homeodomain protein LHX3 , homeobox protein LIM-3 , LIM homeodomain protein 3 , LIM homeodomain 3 protein b isoform , LIM homeo box protein 3 , homeobox protein P-LIM

GENE ID SPECIES
662120 Tribolium castaneum
100224079 Taeniopygia guttata
8022 Homo sapiens
170671 Rattus norvegicus
30455 Danio rerio
397959 Xenopus laevis
373940 Gallus gallus
607584 Canis lupus familiaris
396712 Sus scrofa
539213 Bos taurus
101111265 Ovis aries
16871 Mus musculus
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