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The protein encoded by LHX8 is a member of the LIM homeobox family of proteins, which are involved in patterning and differentiation of various tissue types. Additionally we are shipping LHX8 Antibodies (48) and LHX8 Kits (10) and many more products for this protein.
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Increasing Lhx8 expression in neuronal cell lines also increased acetylcholine release.
Our tagging-single nucleotide polymorphism (tSNP)-based association analysis was negative for Tourette syndrome association with LHX8.
LHX8 might play an important role in odontoma formation. This is 1st report on comparison of LHX8 expression between human odontoma-derived mesenchymal cells and normal adult dental mesenchymal stem cells and its overexpression in human samples.
Sohlh1 (show SOHLH1 Proteins) and Lhx8 are two germ cell-specific, critical regulators of oogenesis
Mutations in the LHX8 exons are uncommon in Caucasian women with premature ovarian failure.
Lhx6 (show LHX6 Proteins) and Lhx8 promote palate development through negative regulation of a cell cycle inhibitor gene, p57Kip2 (show CDKN1C Proteins)
LHX8 can bind to the Lin28a (show LIN28A Proteins) promoter, and the depletion of Lin28a (show LIN28A Proteins) in Lhx8-deficient oocytes partially suppresses primordial oocyte activation.
Studies indicate that LIM (show PDLIM5 Proteins) homeobox (show PRRX1 Proteins) proteins Lhx6 (show LHX6 Proteins) and -8 mRNAs are primarily expressed in the ventral telencephalon, specifically in the medial ganglionic eminence (MGE) of the basal forebrain and in subsets of neurons in the striatum.
WNT/beta-catenin signaling is essential for the expression of Lhx8 in the maxillary arch cells.
Lhx8 expression is related with the activation of primordial follicles, which is highly correlated with the demethylation of Lhx8-3' untranslated region and the high acetylation of histone H3 (show HIST3H3 Proteins).
The homeodomain protein LIM (show PDLIM5 Proteins) homeobox (show PRRX1 Proteins) (Lhx)7 is essential for maintaining the morphological and molecular characteristics of cholinergic interneurons of the striatum.
Lhx6 (show LHX6 Proteins) and Lhx8 coordinately induce neuronal expression of Shh (show SHH Proteins) that controls the generation of interneuron progenitors.
L3/Lhx8 functions may be partially redundant in the mesenchyme of the secondary palate, but not in the palatal epithelium.
Lhx8 plays an important role in the survival of mesenchymal cells of the tooth germ during development.
mice with a null mutation of Lhx8 are deficient in the development of forebrain cholinergic neurons
The protein encoded by this gene is a member of the LIM homeobox family of proteins, which are involved in patterning and differentiation of various tissue types. These proteins contain two tandemly repeated cysteine-rich double-zinc finger motifs known as LIM domains, in addition to a DNA-binding homeodomain. This family member is a transcription factor that plays a role in tooth morphogenesis. It is also involved in oogenesis and in neuronal differentiation. This gene is a candidate gene for cleft palate, and it is also associated with odontoma formation. Alternative splicing of this gene results in multiple transcript variants.
LIM homeobox 8
, LIM/homeobox protein Lhx8
, LIM-homeodomain protein Lhx8
, LIM homeobox protein 8
, LIM homeo box protein 8
, LIM homeobox protein 7
, LIM/homeobox protein Lhx7