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LASP1 encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins.
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Human LASP1 Protein expressed in Escherichia coli (E. coli) - ABIN1047340
Gerhard, Wagner, Feingold, Shenmen, Grouse, Schuler, Klein, Old, Rasooly, Good, Guyer, Peck, Derge, Lipman, Collins, Jang, Sherry, Feolo, Misquitta, Lee, Rotmistrovsky, Greenhut, Schaefer, Buetow et al.: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ... in Genome research 2004
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An in vitro study showed that overexpression of miR (show MLXIP Proteins)-133b inhibited the proliferation, migration, and invasion of HepG2 and Hep3B cells. Similarly, knockdown of LASP1 reduced HepG2 and Hep3B cell proliferation, migration, and invasion.
Findings indicated that LASP-1, as a downstream target of SOX9 (show SOX9 Proteins), may act as a novel biomarker for lung cancer and plays an important role in cell proliferation, migration, and invasion.
miR (show MLXIP Proteins)-203a-3p suppresses tumor growth and metastasis through targeting LASP1 in NPC (show NPC1 Proteins).
LASP1 silencing elicited effects similar to miR (show MLXIP Proteins)-326 overexpression on HCC (show FAM126A Proteins) cells.
A combination of low 14-3-3sigma and high LASP1 expression shows a worse trend with overall survival of colorectal cancer patients.
Furthermore, we identify flotillin-1 (FLOT1 (show FLOT1 Proteins)) and histone H1 (show H1F0 Proteins) as downstream factors for cytoplasmic and nuclear pathway of S100A11 (show S100A11 Proteins), which are required for LASP1-S100A11 (show S100A11 Proteins) axis-mediated epithelial-mesenchymal transition and colorectal cancer progression.
Overexpression of LASP-1 in thyroid cancer tissues.LASP-1 role in thyroid cancer cell proliferation and invasion.LASP-1 is an oncogene (show RAB1A Proteins).
Study found LASP1 to be downregulated after knockdown of PVT1 and overexpression of LASP1 attenuated the tumor-suppressive roles of PVT1 knockdown in esophageal squamous cell carcinoma.
Data indicate that LIM and SH3 protein 1 (LASP1) is a direct target of miR (show MLXIP Proteins)-145.
LASP1 enhances the expression and secretion of MMPs, favoring breast cancer cell migration and invasiveness.
Results defined LASP1 as a direct target gene for HIF1alpha (show HIF1A Proteins) upregulation that is critical for metastatic progression of PDAC.
Data show that MEFs derived from Lasp1(-/-) mice migrated more rapidly in vitro.
LIM-nebulette (show NEBL Proteins), Lasp-1, and zyxin (show ZYX Proteins) may play an important role in the organization of focal adhesions
Lasp-1 is a dynamic focal adhesion protein necessary for cell migration and survival in response to growth factors and ECM (show MMRN1 Proteins) proteins.
Data suggest that there are no functional differences between human and mouse LASP-1.
The role of Lasp1 in the regulation of hydrochloride secretion in vivo was studied in a murine model with a targeted disruption of the Lasp-1 gene.
role of Lasp1 in chondrocyte differentiation during cartilage to bone transition
This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer.
LIM and SH3 domain protein 1
, LIM and SH3 protein 1
, lasp1 protein
, metastatic lymph node gene 50 protein
, MLN 50
, 40 kDa phosphoprotein
, phosphoprotein Lasp-1