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The protein encoded by LAD1 may be an anchoring filament that is a component of basement membranes.
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Here, we focus on the trSNP in LAD1 (show COL17A1 Antibodies), a gene that encodes for Ladinin-1, a collagenous anchoring filament protein of basement membrane that is responsible for maintaining cohesion at the dermal-epidermal junction.
Calcium regulation of EGF (show EGF Antibodies)-induced ERK5 (show MAPK7 Antibodies) activation is mediated through interaction of MEKK2 (show MAP3K2 Antibodies) with the adaptor protein Lad1 (show COL17A1 Antibodies).
The protein encoded by this gene may be an anchoring filament that is a component of basement membranes. It may contribute to the stability of the association of the epithelial layers with the underlying mesenchyme.
, linear IgA disease antigen homolog
, linear IgA bullous dermatosis antigen