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The protein encoded by LGALS2 is a soluble beta-galactoside binding lectin. Additionally we are shipping Lectin, Galactoside-Binding, Soluble, 2 Kits (42) and Lectin, Galactoside-Binding, Soluble, 2 Proteins (21) and many more products for this protein.
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Human Polyclonal LGALS2 Primary Antibody for IHC, IHC (p) - ABIN4313220
Lindskog, Asplund, Engkvist, Uhlen, Korsgren, Ponten: Antibody-based proteomics for discovery and exploration of proteins expressed in pancreatic islets. in Discovery medicine 2010
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analysis of the effect of low-temperature plasma on the expression of galectin-1 (show LGALS1 Antibodies), -2, and -3 in the healing skin compared with those of electrocoagulation conducted with a high-frequency electrical coagulator
Therefore, Cys (show DNAJC5 Antibodies)(57) is suggested to be responsible for oxidative inactivation of the mGal-2 protein, and protection of the sulfhydryl group of the Cys (show DNAJC5 Antibodies)(57) in mGal-2 by S-nitrosylation is likely important for maintaining mGal-2 protein function in an oxidative environment such as the gastrointestinal tract.
Studies of specific knock-out mice show that galectin-2 acts through the CD14/toll-like receptor (TLR)-4 pathway. It lea (show CD14 Antibodies)ds to increased CD40-positive and reduced CD206-positive macrophages around remodeling collateral arteries.
Gal-2 oxidation by H2O2 resulted in the loss of sugar-binding ability, while S-nitrosylation prevented H2O2-inducted inactivation, presumably by protecting the Cys (show DNAJC5 Antibodies) residue(s) in the protein.
Galectin-2 was present in nuclei of murine 3T3 fibroblasts.
In normal murine skin, low levels of galectin-2 messenger RNA are detected.
Study observed decreased methylation at the DHCR24 (show DHCR24 Antibodies) locus in offspring of women with active pregnancy eating disorders (ED) and increased methylation at the LGALS2 locus in offspring of women with past ED compared to controls.
Data show that lactose binding to galectin-2 (Gal-2) stabilizes the lectin's conformation.
Gal-3 was significantly downregulated only in the extravillous trophoblast of intrauterine growth restriction ( IUGR) placentas. In contrast, expressions of gal-2 and gal-13 were downregulated in both villous and extravillous trophoblast cells of IUGR placentas.
Galectin-1 (show LGALS1 Antibodies) was undetectable in normal and ulcerative colitis colonic epithelium, while galectin-2, galectin-3 (show LGALS3 Antibodies), and galectin-4 (show LGALS4 Antibodies) were strongly expressed.
Galectin-2 binding to different circulating human monocyte subsets depends on monocyte surface expression levels of CD14 (show NDUFA2 Antibodies). It skews human macrophages to a M1-like proinflammatory phenotype.
PPARG (show PPARG Antibodies) rs1152002, AGTR1 (show AGTR1 Antibodies) rs5186, CXCL16 (show CXCL16 Antibodies) rs3744700 and LGALS2 rs7291467 polymorphisms may be closely related to the development of coronary heart disease
Lower LGALS2 gene expression is associated with acute myeloid leukemia (show BCL11A Antibodies).
Data suggest that expression of galectin 2 and galectin 2 mRNA is down-regulated in placental extravillous trophoblast and decidua in women with pre-eclampsia as compared to women with normal term pregnancy.
Gal-1 (show LGALS1 Antibodies), 2, and 3 levels were high in maintenance hemodialysis patients. Kidney transplantation improved gal-1 (show LGALS1 Antibodies), 2, and 3 levels.
The increased circulation of galectins -2, -4 and -8 in cancer patients contributes substantially to the increased circulation of G-CSF (show CSF3 Antibodies), IL-6 (show IL6 Antibodies) and MCP-1 (show CCL2 Antibodies) by interaction with the blood vascular endothelium
Galectin-3 (show LGALS3 Antibodies)-positive macrophages in all tissues bovine female reproductive organs are involved in either cell survival or death.
These findings suggest that galectin-3 (show LGALS3 Antibodies) expression plays a role in the maturation and activation of sperm in bulls.
galectin-3 (show LGALS3 Antibodies) is associated with the formation of chronic granulation tissues in bovine paratuberculosis
The protein encoded by this gene is a soluble beta-galactoside binding lectin. The encoded protein is found as a homodimer and can bind to lymphotoxin-alpha. A single nucleotide polymorphism in an intron of this gene can alter the transcriptional level of the protein, with a resultant increased risk of myocardial infarction.
lectin, galactoside-binding, soluble, 3
, lectin, galactoside-binding, soluble, 2
, galectin 2
, S-Lac lectin 2
, beta-galactoside-binding lectin L-14-II
, lactose-binding lectin 2
, lectin galactoside-binding soluble 2 (galectin 2)
, lectin, galactoside-binding, soluble, 2 (galectin 2)