anti-Lectin, Galactoside-Binding, Soluble, 9 (LGALS9) Antibodies

LGALS9 was initially thought to represent a pseudogene of galectin 9; however, this transcript has good exon-intron structure and encodes a predicted protein of the same size as and highly similar to galectin 9. Additionally we are shipping Lectin, Galactoside-Binding, Soluble, 9 Kits (66) and Lectin, Galactoside-Binding, Soluble, 9 Proteins (43) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
LGALS9 16859 O08573
LGALS9 3965 O00182
LGALS9 25476 P97840
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Top anti-Lectin, Galactoside-Binding, Soluble, 9 Antibodies at antibodies-online.com

Showing 10 out of 201 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-LGALS9 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: Human Muscle 100 μL Log in to see 2 to 3 Days
$319.00
Details
Rat Rabbit Un-conjugated WB Observed bind size: 36KD 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated IC, IF, IHC, WB Immunofluorescent analysis of Galectin 9 staining in THP1 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of Galectin 9 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of Galectin-9 Antibody (N-term) in WiDr cell line lysates (35ug/lane). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of Galectin-9 expression in Jurkat cell lysate (Lane 1, 2). 100 μg Log in to see 2 to 3 Days
$245.00
Details
Human Rabbit Un-conjugated IF, ELISA, WB Western blot analysis of extracts from HepG2 cells, using LEG9 Antibody. The lane on the right is treated with the synthesized peptide. Immunofluorescence analysis of NIH-3T3 cells, using LEG9 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Cow Rabbit Un-conjugated WB Host: Rabbit Target Name: LGALS9 Sample Tissue: Human HCT15 Whole Cell Antibody Dilution: 1ug/ml 100 μL Log in to see 2 to 3 Days
$289.00
Details
Mouse Rabbit Un-conjugated ICC, IHC, WB Figure. DAB staining on IHC-P; Samples: Mouse Kidney Tissue. 100 μg Log in to see 13 to 16 Days
$324.00
Details
Mouse Goat Un-conjugated CyTOF, FACS, ICC, WB Detection of Galectin-9 in Mouse Thymocytes by Flow Cytometry. Galectin-9 in Mouse Splenocytes. Galectin-9 was detected in immersion fixed mouse splenocytes using Goat Anti-Mouse Galectin-9 Antigen Affinity-purified Polyclonal Antibody  at 15 ug/mL for 3 hours at room temperature. Cells were stained using the NorthernLightsル 557-conjugated Anti-Goat IgG Secondary Antibody (red 100 μg Log in to see 8 to 9 Days
$416.97
Details
Human Mouse Un-conjugated ELISA (Capture), FACS 0.1 mg Log in to see 6 to 8 Days
$401.50
Details

Top referenced anti-Lectin, Galactoside-Binding, Soluble, 9 Antibodies

  1. Mouse (Murine) Polyclonal LGALS9 Primary Antibody for CyTOF, FACS - ABIN4899254 : Iqbal, Sampaio, Maione, Greco, Niki, Hirashima, Perretti, Cooper: Endogenous galectin-1 and acute inflammation: emerging notion of a galectin-9 pro-resolving effect. in The American journal of pathology 2011 (PubMed)
    Show all 4 Pubmed References

  2. Human Polyclonal LGALS9 Primary Antibody for ELISA, WB - ABIN561667 : Bellac, Coimbra, Simon, Imboden, Leib: Gene and protein expression of galectin-3 and galectin-9 in experimental pneumococcal meningitis. in Neurobiology of disease 2007 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal LGALS9 Primary Antibody for IF (p), IHC (p) - ABIN733163 : Daley, Mani, Mohan, Akkad, Ochi, Heindel, Lee, Zambirinis, Pandian, Savadkar, Torres-Hernandez, Nayak, Wang, Hundeyin, Diskin, Aykut, Werba, Barilla, Rodriguez, Chang, Gardner, Mahal, Ueberheide et al.: Dectin 1 activation on macrophages by galectin 9 promotes pancreatic carcinoma and peritumoral immune tolerance. ... in Nature medicine 2017 (PubMed)

More Antibodies against Lectin, Galactoside-Binding, Soluble, 9 Interaction Partners

Mouse (Murine) Lectin, Galactoside-Binding, Soluble, 9 (LGALS9) interaction partners

  1. galectin-9 mediates the close association of IgM and CD22.

  2. m4-1BBL and Gal-9 act together to aid aggregation of m4-1BB monomers to efficiently initiate m4-1BB signaling.

  3. this study shows that impaired Gal-9 dysregulates the blood mononuclear cells-induced Th1/Th2 imbalance in abortion-prone matings

  4. Gal9 may be a new immunomodulatory target for macrophages.

  5. these findings reveal a critical role for Tim-3-Gal-9 signaling-mediated immunoregulation by pNK cells in maternal-fetal immune tolerance and suggest that Tim-3 abundance on pNK cells is a potential biomarker for recurrent miscarriage diagnosis.

  6. in a model of experimental autoimmune encephalomyelitis, we show that an agonist of DR3 suppressed disease, correlating with expansion of CD4+Foxp3+ Tregs, and this protective effect was lost in Galectin-9-/- mice

  7. Galectin 9 is a novel dectin 1 ligand in pancreatic ductal adenocarcinoma. Upon disruption of the dectin 1-galectin 9 axis, CD4(+) and CD8(+) T cells, which are dispensable for PDA progression in hosts with an intact signaling axis, become reprogrammed into indispensable mediators of anti-tumor immunity.

  8. The Gal-9/Tim-3 signal is important for the regulation of decidua NK cells function, which is beneficial for the maintenance of a normal pregnancy.

  9. present in the spongiotrophoblast layer of the haemochorial placenta

  10. These results indicate the possibility that cooperative binding of oligosaccharide and neighboring polypeptide structures of monoclonal IgE to galectin-9 affects the overall affinity and specificity of the IgE-lectin interaction.

  11. galectin-9 functions as a novel alarmin by augmenting the inflammatory response in sepsis development during pulmonary F. novicida infection.

  12. Gal-9 has a role in the maintenance of hepatic homeostasis and preventing liver ischemia-reperfusion injury

  13. Gal-9, a natural TIM-3 ligand, was produced primarily by and released from ischemia-reperfusion-stressed hepatocytes, both in vivo and in vitro.

  14. Galectin-9 functions as an astrocyte-microglia communication signal and promotes cytokine production from microglia in a Tim-3 independent manner.

  15. galectin-9, in addition to being an effector molecule for regulatory T cells cells, acts synergistically with TGF-beta to enforce iTreg cell differentiation and maintenance.

  16. Galectin-9 is a suppressor of T and B cells and predicts the immune modulatory potential of mesenchymal stromal cell preparations.

  17. action of agonist anti-4-1BB in suppressing autoimmune and allergic inflammation was completely dependent on Galectin-9 (Gal-9). Gal-9 directly bound to 4-1BB, in a site distinct from the binding site of antibodies and the natural ligand of 4-1BB

  18. Tim-3/galectin-9 pathway plays a critical role in the homeostasis of hepatic Tregs through the elimination induction in Teffs and the inhibition of IFN-gamma release.

  19. Gal-9 expressed on corneal endothelial cells protects them from destruction by allo-reactive T cells within the cornea.

  20. contributes to the inducible immunomodulatory functions of mesenchymal stromal cells

Human Lectin, Galactoside-Binding, Soluble, 9 (LGALS9) interaction partners

  1. Gal-9 intrinsically regulates B cell activation and may differentially modulate B cell receptor signaling at steady state and within germinal centers.

  2. High GAL9 expression is associated with gastric cancer.

  3. In conclusion, these findings suggest that the serum levels of Gal-1, Gal-3, and Gal-9 may be associated with large artery atherosclerotic stroke.

  4. Gal-9 is a promising biomarker for allograft dysfunction, but unable to differentiate allograft rejection from other causes of renal dysfunction in kidney transplantation recipients

  5. this study showed that blood level of galectin-9 increased during pregnancy

  6. Studies indicate tumor-derived galectin-1, galectin-3 and galectin-9 in various cancers and anticancer therapies that target these molecules [Review].

  7. Gal-9 expression determined the DFS and OS of ovarian cancer patients in two opposing ways-moderate Gal-9 expression was correlated with a reduced outcome as compared to Gal-9 negative cases, while patients with high Gal-9 expression showed the best outcome.

  8. these data indicate a novel role for galectin-9 in modulating innate immunity by inducing aldehyde dehydrogenase activity in CD103+ dendritic cells

  9. Gal-9 was down modulated in stroma of patients with chronic gastritis and Helicobacter pylori infection.

  10. T-cell immunoglobulin mucin-3/galectin-9 (Tim-3/Gal-9) binding signaling can also engage other binding partners to induce distinct cellular responses [Review].

  11. the present study was the first to report the participation of Gal-9 in Chagas disease

  12. The interaction between Gal-9/TIM-3 pathway and follicular helper cells contributed to viral persistent in chronic hepatitis C virus infection.

  13. Our data reveal that Gal9 suppresses the growth of liver metastasis, possibly by inducing apoptosis through a mechanism involving mitochondria and changes in miRNA expression. Thus, Gal9 might serve as a therapeutic agent for the treatment of liver metastasis from pancreatic cancer.

  14. Exosomal total protein, Tim-3 and Galectin-9 were up-regulated in non-small cell lung cancer plasma.

  15. Galectin-9, a soluble lectin expressed by T cells, endothelial cells and dendritic cells, binds to and retains PDI on the cell surface.

  16. results suggested that Tim-3 and Gal-9 could downregulate T cell inflammation in Osteoarthritis

  17. Results show that human acute myeloid leukemia (AML) cells possess a secretory pathway which leads to the production and release of soluble Tim-3 and galectin-9. Both proteins prevent the activation of NK cells and impair their AML cell-killing activity.

  18. Significantly elevated Gal-9 levels were found in both minimal-mild (I-II) and moderate-severe (III-IV) stages of endometriosis in comparison with healthy controls.

  19. We investigated tumor-infiltrating CD4 and CD8 T cells and the expression of PD-L1, Galectin-9, and XAGE1 in stage I to IIIA lung adenocarcinomas using a tissue microarray to deduce their contribution to overall survival, and our data showed that PD-L1 expression was a positive indicator, whereas Galectin-9 and XAGE1 expression was negative.

  20. Tim3/Gal-9 alleviates the inflammation of TAO patients via suppressing Akt/NF-kappaB signaling pathway.

Cow (Bovine) Lectin, Galactoside-Binding, Soluble, 9 (LGALS9) interaction partners

  1. The Tim-3/Gal-9 pathway might link disease progression with T cell exhaustion during bovine leukemia virus infection.

  2. The relative abundance of PIBF, LGALS1, LGALS3, LGALS3BP, and LGALS9 mRNA would display a differential expression pattern in the endometrium.

Lectin, Galactoside-Binding, Soluble, 9 (LGALS9) Antigen Profile

Protein Summary

The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The protein encoded by this gene is an S-type lectin. It is overexpressed in Hodgkin's disease tissue and might participate in the interaction between the H&RS cells with their surrounding cells and might thus play a role in the pathogenesis of this disease and/or its associated immunodeficiency. Multiple alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with LGALS9

  • galectin 9 L homeolog (lgals9.L) antibody
  • galectin 9 (lgals9) antibody
  • lectin, galactoside-binding, soluble, 9 (galectin 9)-like 3 (lgals9l3) antibody
  • galectin 9 (LGALS9) antibody
  • galectin 9 (Lgals9) antibody
  • lectin, galactose binding, soluble 9 (Lgals9) antibody
  • AA407335 antibody
  • AI194909 antibody
  • AI265545 antibody
  • ecalectin antibody
  • gal-9 antibody
  • galectin-9 antibody
  • HUAT antibody
  • Lgals5 antibody
  • LGALS9 antibody
  • LGALS9A antibody
  • LGALS35 antibody
  • UAT antibody
  • UATP.I antibody
  • wu:fd20c09 antibody
  • zgc:111833 antibody

Protein level used designations for LGALS9

lectin, galactoside-binding, soluble, 9 , galactoside-binding soluble lectin 9 , galectin 9 , lectin, galactoside-binding, soluble, 9 (galectin 9) , galectin-9 , lectin, galactose binding, soluble 5 , ecalectin , gal-9 , tumor antigen HOM-HD-21 , urate transporter/channel protein , 36 kDa beta-galactoside-binding lectin , Lectin galactose binding soluble 9 (Galectin-9) , Lectin, galactose binding, soluble 9 (Galectin-9) , UAT , urate transporter/channel , urate transporter , urate transporter/channel protein, isoform (UATp,i)

GENE ID SPECIES
733366 Xenopus laevis
100145704 Xenopus (Silurana) tropicalis
327284 Danio rerio
454519 Pan troglodytes
100350347 Oryctolagus cuniculus
100728329 Cavia porcellus
16859 Mus musculus
3965 Homo sapiens
25476 Rattus norvegicus
442861 Canis lupus familiaris
396972 Sus scrofa
510813 Bos taurus
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